The effect of different antihypertensive drugs on cavernous tissue in experimental chronic renal insufficiency

Journal of Nephrology

Volumn 19, Issue 4, 2006, Pages 419-428

  Toblli, Jorge E ^a   Stella, Inés ^b   Mazza, Osvaldo N ^a   Ferder, León ^b   Inserra, Felipe ^b  

^a HOSPITAL ALEMÁN   (Argentina)

^b Instituto de Investigaciones Cardiológicas   (Argentina)

Author keywords

End stage renal disease; Male erectile dysfunction; Renin angiotensin system; Vascular remodeling

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; AMLODIPINE; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; ATENOLOL; BENAZEPRIL; COLLAGEN TYPE 3; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LOSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; CORPUS CAVERNOSUM; CORRELATION ANALYSIS; CREATININE CLEARANCE; DISEASE SEVERITY; ERECTILE DYSFUNCTION; GLOMERULOSCLEROSIS; HISTOPATHOLOGY; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE DAMAGE; MALE; MICROSCOPY; NONHUMAN; PARTIAL NEPHRECTOMY; PENIS; PREVALENCE; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RENOVASCULAR HYPERTENSION; SMOOTH MUSCLE; STATISTICAL SIGNIFICANCE; VASCULAR SMOOTH MUSCLE;

EID: 35349007388     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA 1993; 270: 83-90.
2. Feldman HA, Goldstein I, Hatzichristou DG, Krane RI, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the male aging study. J Urol 1994; 151: 54-61.
3. Bansal S. Sexual dysfunction in hypertensive men: a critical review of the literature. Hypertension 1988: 12: 1-10.
4. Burchardt M, Burchardt T, Anastasiadis AG, Kiss AJ, Shabsigh A, de La Taille A, Pawar RV, Baer L, Shabsigh R. Erectile dysfunction is a marker for cardiovascular complications and psychological functioning in men with hypertension. Int J Impot Res 2001; 13: 276-81.
5. Levine LA. Diagnosis and treatment of erectile dysfunction. Am J Med 2000; 109 (Suppl 9A): 3S-12S.
6. Burchardt M, Burchardt T, Baer L, Kiss AJ, Pawar RV, Shabsigh A, de la Taille A, Hayek OR, Shabsigh R. Hypertension is associated with severe erectile dysfunction. J Urol 2000; 164: 1188-91.
7. Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinman KP, McKinlay JB. Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts Male Aging Study. J Urol 2000; 163: 460-3.
8. Turk S, Karalezli G, Tonbul HZ, Yildiz M, Altintepe L, Yildiz A, Yeksan M. Erectile dysfunction and the effects of sildenafil treatment in patients on haemodialysis and continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant 2001; 16: 1818-22.
9. Rosas SE, Joffe M, Franklin E, Strom BL, Kotzker W, Brensinger C, Grossman E, Glasser D, Feldman HI. Prevalence and determinants of erectile dysfunction in hemodialysis patients. Kidney Int 2001; 59: 2259-66.
10. Cequeira J. Morales M, Glina S. Erectile dysfunction: prevalence and associated variables in patients with chronic renal failure. Int J Impot Res 2002; 14: 65-71.
11. Neto AF, Freitas Rodrigues MA, Saraiva Fittipaldi JA, Moreira ED Jr. The epidemiology of erectile dysfunction and its correlates in men with chronic renal failure on hemodialysis in Londrina, southern Brazil. Int J Impot Res 2002; 14: 519-26.
12. Naya Y, Soh J, Ochiai A, Mizutani Y, Ushijima S, Kamoi K, Ukimura O, Kawauchi A, Fujito A, Ono T, Iwamoto N, Aoki T, Imada N, Marumo K, Murai M, Miki T. Significant decrease of the International Index of Erectile Function in male renal failure patients treated with hemodialysis. Int J Impot Res 2002; 14: 172-7.
13. Arslan D, Aslan G, Sifil A, Cavdar C, Celebi I, Gamsari T, Esen AA. Sexual dysfunction in male patients on hemodialysis: assessment with the International Index of Erectile Function (IIEF). Int J Impot Res 2002; 14: 539-42.
14. Rosas SE. Wasserstein A. Kobrin S. Feldman HL. Preliminary observations of sildenafil treatment for erectile dysfunction in dialysis patients. Am J Kidney Dis 2001; 37: 134-7.
15. Toblli JE, Stella I, Inserra F, Ferder L, Zeller FL, Mazza ON. Morphologic changes in cavernous tissue in spontaneously hypertensive rats. Am J Hypertens 2000; 13: 686-92.
16. Toblli JE, Stella I, Mazza ON, Ferder L, Inserra F. Candesartan cilexetil protects cavernous tissue in spontaneously hypertensive rats. Int J Impot Res 2004; 16: 305-12.
17. Toblli JE, Stella I, Mazza ON, Ferder L, Inserra F. Different effect of losartan and amlodipine on penile structures in male spontaneously hypertensive rats. Am J Nephrol 2004; 24: 614-23.
18. Adams MA, Banting JD, Maurice DH, Morales A, Heaton JP. Vascular control mechanisms in penile erection: phylogeny and the inevitability of multiple and overlapping systems. Int J Impot Res 1997; 9: 85-91.
19. Azadzoi KM, Siroky MB, Goldstein I. Study of etiologic relationship of arterial atherosclerosis to corporal veno-occlusive dysfunction in the rabbit. J Urol 1996; 155: 1795-800.
20. Azadzoi KM, Goldstein I, Siroky MB. Relationship between cavernosal ischemia and corporal veno-occlusive dysfunction in an animal model. J Urol 1997; 157: 1011-7.
21. Andersson KE, Wagner G. Physiology of penile erection. Physiol Rev 1995; 75: 191-236.
22. Navar LG, Inscho EW, Majid SA, Imig JD, Harrison-Bernard LM, Mitchell KD. Paracrine regulation of the renal microcirculation. Physiol Rev 1996; 76: 425-536.
23. O'Callaghan CJ, Williams B. The regulation of human vascular smooth muscle extracellular matrix protein production by alpha- and beta-adrenoceptor stimulation. J Hypertens 2002; 20: 287-94.
24. Brilla CG. Regression of myocardial fibrosis in hypertensive heart disease: diverse effects of various antihypertensive drugs. Cardiovasc Res 2000; 46: 324-31.
25. Schiffrin EL. Effect of antihypertensive treatment on small artery remodeling in hypertension. Can J Physiol Pharmacol 2003; 81: 168-76.
26. Sharifi AM, Li JS, Endemann D, Schiffrin EL. Effects of enalapril and amlodipine on small-artery structure and composition, and on endothelial dysfunction in spontaneously hypertensive rats. J Hypertens 1998; 16: 457-66.
27. Wenzel RR, Noll G, Luscher TF. Endothelial regulation of vascular tone and growth: role of calcium antagonists. In Epstein M (Ed). Calcium antagonists in clinical medicine (3rd edn). Philadelphia: Hanley & Belfus 2002; 41-57.
28. Roth M, Eickelberg O, Kohler E, Erne P, Block LH. Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix. Proc Natl Acad Sci U S A 1996; 93: 5478-82.
29. Kifor I, Williams GH, Vickers MA, Sullivan MP, Jodbert P, Dluhy RG. Tissue angiotensin II as a modulator of erectile function: Part I: angiotensin peptide content, secretion and effects in the corpus cavernosum. J Urol 1997; 157: 1920-5.
30. Park JK, Kim SZ, Kim SH, Park YK, Cho KW. Renin angiotensin system in rabbit corpus cavernosum: functional characterization of angiotensin II receptors. J Urol 1997; 158: 653-8.
31. Becker AJ, Uckert S, Stief CG, Scheller F, Knapp WH, Hartmann U, Jonas U. Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction. Urology 2001; 58: 805-10.
32. Stanley AG, Patel H, Knight AL, Williams B. Mechanical strain-induced human vascular matrix synthesis: the role of angiotensin II. J Renin Angiotensin Aldosterone Syst 2000; 1: 32-5.
33. Laursen JB, Rajagopalan S, Galis Z, Tarpey M, Freeman BA, Harrison DG. Role of superoxide in angiotensin-II-induced but not catecholamine-induced hypertension. Circulation 1997; 95: 588-93.
34. Hale TM, Okabe H, Heaton JPW, Adams MA. Antihypertensive drugs induce structural remodeling of the penile vasculature. J Urol 2001; 166: 739-45.
35. Toblli JE, Stella I, Nestor Mazza O, Ferder L, Inserra F. Protection of cavernous tissue in male spontaneously hypertensive rats: beyond blood pressure control. Am J Hypertens 2004; 17: 516-22.