Bridging knowledge gaps on the long road to regeneration: Classical models meet stem cell manipulation and bioengineering

Molecular Interventions

Volumn 7, Issue 5, 2007, Pages 249-250

  Tsonis, Panagiotis A ^a  

^a UNIVERSITY OF DAYTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOENGINEERING; CELL LINEAGE; CELL MANIPULATION; ECTODERM; EMBRYONIC STEM CELL; ENDODERM; FIBROBLAST; GENE EXPRESSION; GERM CELL; INVERTEBRATE; MESENCHYMAL STEM CELL; MESODERM; MOLECULAR EVOLUTION; MULTIPOTENT STEM CELL; NONHUMAN; PLURIPOTENT STEM CELL; SALAMANDER; SHORT SURVEY; SIGNAL TRANSDUCTION; STEM CELL; TOTIPOTENT STEM CELL;

ANIMALS; BIOMEDICAL ENGINEERING; HUMANS; PLURIPOTENT STEM CELLS; REGENERATION;

EID: 35349003605     PISSN: 15340384     EISSN: 15432548     Source Type: Journal    
DOI: 10.1124/mi.7.5.6     Document Type: Short Survey

References (12)

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2. Rosenthal, N. Youthful prospects for human stem-cell therapy. In another few decades, revised attitudes toward stem cells could lead to disease prevention and life extension. EMBO Rep. 6, S30-S40 (2005).
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5. Wernig, M., Meissner, A., Foreman, R., Brambrink, T., Ku, M., Hochedlinger, K., Bernstein, B.E., and Jaenisch, R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448, 318-324 (2007). Cited articles 4 and 5 demonstrate that fibroblasts can be reprogrammed in vitro to become pluripotent stem cells. Moreover, they show that when these cells are selected for Nanog expression, they behave like embryonic stem cells and are able to contribute to all tissues in a chimaeric mouse.
6. Maki, N., Takechi, K., Sano, S., Tarui, H., Sasai, Y., and Agata, K. Rapid accumulation of nucleostemin in nucleolus during newt regeneration. Dev Dyn. 236, 941-950 (2007). This paper indicates that a stem cell-and cancer-specific marker, nucleostemin, is activated during lens regeneration in adult newts. Such an observation supports earlier ideas that newt cells might revert to a kind of stem cell.
7. Mikos, A.G., Herring, S.W., Ochareon, P. et al. Engineering complex tissues. Tissue Eng. 12, 3307-3339 (2006).
8. Andersson, K.E. and Christ, G.J. Regenerative pharmacology: The future is now. Mol. Interv. 7, 79-86 (2007).
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10. Yamada, K.M. and Cukierman, E. Modeling tissue morphogenesis and cancer in 3D. Cell 130, 601-610 (2007).
11. Grogg, M.W., Call, M.K., Okamoto, M., Vergara. M.N., Del Rio-Tsonis, K., and Tsonis, P.A. BMP inhibition-driven regulation of six-3 underlies induction of newt lens regeneration. Nature 438, 858-862 (2005). First paper to indicate that induction of lens regeneration from a regeneration-incompetent tissue is possible.
12. Ooto, S., Haruta, M., Honda, Y., Kawasaki, H., Sasai, Y., and Takahashi, M. Induction of the differentiation of lentoids from primate embryonic stem cells. Invest Ophthalmol Vis. Sci. 44, 2689-2693 (2003). This paper shows that ES cells can give rise to lens cells and shows the potential use of ES cells to create lenses.