Clinical evaluation of novel buccoadhesive film containing ketorolac in dental and post-oral surgery pain management

Pharmazie

Volumn 62, Issue 10, 2007, Pages 773-778

  Alsarra, Ibrahim A ^a,c   Alanazi, F K ^a   Mahrous, G M ^a   Abdel Rahman, A A ^a   Al Hezaimi, K A ^b  

^a Dental University Clinic   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPOL 934; HYDROXYLPROPYL METHYL CELLULOSE; KETOROLAC TROMETAMOL; METHYLCELLULOSE; PLACEBO; UNCLASSIFIED DRUG;

ADULT; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENTAL SURGERY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG RELEASE; DRUG SCREENING; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN EXPERIMENT; MALE; MOUSE; NONHUMAN; ORAL SURGERY; PAIN; PAW EDEMA; RANDOMIZED CONTROLLED TRIAL; RAT;

ADOLESCENT; ADULT; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; CHEMISTRY, PHYSICAL; DIFFUSION; DOUBLE-BLIND METHOD; EDEMA; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; KETOROLAC; MALE; MICE; MIDDLE AGED; MOUTH MUCOSA; ORAL SURGICAL PROCEDURES; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; POLYMERS; RATS; REACTION TIME; TISSUE ADHESIVES; TOOTH EXTRACTION;

EID: 35349003214     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2007.10.7028     Document Type: Article

References (18)

1. Abbas SM, Kamal RS, Afshan G (2004) Effect of ketorolac on postoperative pain relief in dental extraction cases - a comparative study with pethidine. Pak Med Assoc 54: 319-322.
2. Alanazi FK, Abdel Rahman AA, Mahrous GM, Alsarra IA (2006) Formulation and physicochemical characterization of buccoadhesive films containing ketorolac (Submitted to J Drug Deliv Sci Technol).
3. Agarwal V, Mishra B (1999) Design, Development and biopharmaceutical properties of bucco-adhesive compacts of pentazocaine. Drug Dev Ind Pharm 25: 701-709
4. Buckley MMT, Brogden RN (1990) Ketorolac: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. Drugs 39: 86-109.
5. Chi SC, Jun HW (1990) Anti-inflammatory activity of ketoprofen gel on carrageenan-induced paw edema in rats. J Pharm Sci 79: 974-977.
6. Cordero JA, Camacho R, Obach R, Domenech J, Vila L (2001) In vitro based index of topical anti-inflammatory activity to compare a series of NSAIDs. Eur J Pharm and Biopharm 51: 135-142.
7. Gu L, Chiang HS, Becker A (1988) Kinetic and mechanisms of autotoxidation of ketorolac tromethamine in aqueous solution. Inter J Pharm 4: 95-104.
8. Keim GR, Burchanan W, Meredith MP, Offenbacher S, Mankodi SM, Dobrozsi DJ, Bapat NV, Collins JG, Wehmeyer KR, Eichhold TH, Doyle M (1996) Evaluation of ketorolac concentrations in plasma and gingival cervicular fluid following topical treatment with oral rinses and dentifrices. J Pharm Sci 58: 842-847
9. Maliekal J, Elboim CM (1995) Gastrointestinal complications associated with intramuscular ketorolac tromethamine therapy in the elderly. Ann Pharmacother 29: 698-701
10. Morszczak EJ, Jung D, Yee J, Bynum L, Sevelius H (1990) Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular and oral administration in humans and animals. Pharmacotherapy 10: 33S-39S.
11. Mulshine JL, Atkinson JC, Greer RO (2004) Randomized, double blind, placebo-controlled phase IIB trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukolakia. Acalin Cancer Res 10: 1565-1573.
12. Olmedo MV, Galvez R, Vallecillo M (2001) Double blind parallel comparison of multiple doses of Ketorolac, ketoprofen and placebo administrated orally to patients with postoperative dental pain. Pain 90: 135-141.
13. Peh KK, Wong CF (1999) Polymeric films as vehicle for buccal delivery: swelling, mechanical and bioadhesive properties. J Pharm Pharmaceut Sci 2: 53-61.
14. Raza M, Al-Shabanah O, AL-Harbi M, El-Hadiyah TM, Qureshi S (2000) Antinociceptive activity of vigabatrine in mice. Saudi Pharm J 4: 164-173.
15. Scott J, Huskisson EC, Pain Z (1976) Graphic representation of pain. Pain 2: 175-184.
16. Vinegar R (1968) Quantitative studies concerning kaolin edema formation in rats. J Pharmcol Exp Ther 161: 389-395.
17. Walton GM, Rood JP, Snowdon AT, Rickwood D (1993) ketorolac and diclofenac for postoperative pain relief following oral surgery. Br J Oral Maxillofac Surg 31: 158-160.
18. Winter CA (1964) Anti-inflammatory testing methods: comparative evaluation of indomethacin and other agents. In: Garattini S, Dukers MNG (Eds), International symposium on non-steroidal anti-inflammatory drugs. Excerpta medica foundation, Amsterdam, 190-192.