New 4α-methyl steroids from a Chinese soft coral Nephthea sp.

Steroids

Volumn 72, Issue 14, 2007, Pages 901-907

  Ma, Ke ^a   Li, Wei ^b   Fu, Hongwei ^b   Koike, Kazuo ^b   Lin, Wenhan ^a   van Ofwegen, Leen ^c   Fu, Hongzheng ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b TOHO UNIVERSITY   (Japan)

^c NATURALIS BIODIVERSITY CENTER   (Netherlands)

Author keywords

4 Methyl steroids; Nephthea sp.; Polyoxygenated steroids; Soft coral

Indexed keywords

24 METHYLENCHOLESTEROL; 4ALPHA METHYLERGOST 24(28) EN 3BETA,11BETA,DIOL 23 ONE; 4ALPHA METHYLERGOST 7,24(28) DIENE 3BETA OL 23 ONE; 4ALPHA METHYLERGOST 8(14),24(28) DIENE 3BETA OL 23 ONE; ERGOST 5,24(28) DIENE 3BETA,23S DIOL; ERGOST 5,25 DIENE 3BETA,24S,28 TRIOL; STEROID; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CORAL; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; NEPHTHEA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; ANTHOZOA; CHEMICAL STRUCTURE; CHEMISTRY; CHINA; ISOLATION AND PURIFICATION;

ALCYONACEA; NEPHTHEA;

ANIMALS; ANTHOZOA; CHINA; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; STEROIDS;

EID: 35349000022     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2007.07.006     Document Type: Article

References (15)

1. Blunt J.W., Copp B.R., Munro M.H.G., Northcote P.T., and Prinsep M.R. Marine natural products. Nat Prod Rep 23 (2006) 26-78 (and previous reports in this series)
2. Zhang W.H., Liu W.K., and Che C.T. Polyhydroxylated steroids and other constituents of the soft coral Nephthea chabroli. Chem Pharm Bull 51 (2003) 1009-1011
3. Anjaneyulu V., Subba Rao P.V., Radhika P., Laatsch H., and Asolkar R.N. A new glycolipid and a new monohydroxy sterol from Cladiella species of Andaman and Nicobar Islands. Indian J Chem B 40 (2001) 405-409
4. Mehta G., Venkateswarlu Y., Rao M.R., and Uma R. A novel 4α-methyl steroid from the soft coral Nephthea chabroli. J Chem Res (1999) 628-629
5. Rodriguez A.D., Rivera J., and Boulanger A. New polyhydroxydinostane sterols from the Caribbean gorgonian octocoral Pseudopterogorgia americana. Tetrahedron Lett 39 (1998) 7645-7648
6. Bortolotto M., Braekman J.C., Daloze D., and Tursch B. Chemical studies of marine invertebrates. XXIX. 4α-Methyl-3β,8β-dihydroxy-5-ergost-24(28)-en-23-one, a novel polyoxygenated steroid from the soft coral Litophyton viridis. Steroids 30 (1977) 159-164
7. Kokke W.C.M.C., Bohlin L., Fenical W., and Djerassi C. Novel dinoflagellate 4α-methyl steroids from four Caribbean gorgonians. Phytochemistry 21 (1982) 881-887
8. Kobayashi M., Ishizaka T., and Mitsuhashi H. Marine steroids. Minor constituents of the steroids of the soft coral Sarcophyton glaucum. Steroids 40 (1982) 209-221
9. Kokke W.C.M.C., Fenical W., and Djerassi C. Steroids with unusual nuclear unsaturation from three cultured marine dinoflagellates. Phytochemistry 20 (1981) 127-134
10. Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., et al. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 48 (1988) 589-601
11. Scudiero D.A., Shoemaker R.H., Paull K.D., Monks A., Tierney S., Nofziger T.H., et al. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 48 (1988) 4827-4833
12. Vincent V.V., David L., Ramji D.B., Sharan S., and Garg K.N. Potential biogenetic precursors of withanolides from Withania coagulans. Phytochemistry 22 (1983) 2253-2257
13. Iorizzi M., Bryan P., McClintock J., Minale L., Palagiano E., Maurell S., et al. Chemical and biological investigation of polar constituents of the starfish Luidia clathrata, collected in the Gulf of Mexico. J Nat Prod 58 (1995) 653-671
14. Su J.H., Lin F.Y., Huang H.C., Dai C.F., Wu Y.C., Hu W.P., et al. Novel steroids from the soft coral Nephthea chabrolii. Tetrahedron 63 (2007) 703-707
15. Idler D.R., and Fagerlund U.H.M. Marine steroids. I. Isolation of 24-methylenecholesterol from molluscs. J Am Chem Soc 77 (1955) 4142-4144