Modification of Kolmogorov-Smirnov test for DNA content data analysis through distribution alignment

Assay and Drug Development Technologies

Volumn 5, Issue 5, 2007, Pages 663-672

  Huang, Shuguang ^a   Yeo, Adeline A ^a   Li, Shuyu Dan ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DATA ANALYSIS; DNA CONTENT; HIGH THROUGHPUT SCREENING; KOLMOGOROV SMIRNOV TEST; ROC CURVE; SIMULATION; STATISTICAL DISTRIBUTION; ALGORITHM; COMPUTER SIMULATION; DRUG SCREENING; HELA CELL; HUMAN; METHODOLOGY; PHENOTYPE; SPECTROFLUOROMETRY; STATISTICAL ANALYSIS; STATISTICAL MODEL; STATISTICS;

ANTINEOPLASTIC AGENT; DNA; NOCODAZOLE;

ALGORITHMS; ANTINEOPLASTIC AGENTS; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; DNA; DRUG EVALUATION, PRECLINICAL; HELA CELLS; HUMANS; MODELS, STATISTICAL; NOCODAZOLE; PHENOTYPE; SPECTROMETRY, FLUORESCENCE;

EID: 35348999644     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2007.071     Document Type: Article

References (16)

1. Taylor DL, Giuliano KA: Multiplexed high content screening assays create a systems cell biology approach to drug discovery. Drug Discov Today Technol 2005;2:149-154.
2. Taylor DL, Woo ES, Giuliano KA: Real-time molecular and cellular analysis: the new frontier of drug discovery. Curr Opin Biotechnol 2001;12:75-81.
3. Watson JV: Proof without prejudice revisited: immunofluorescence histogram analysis using cumulative frequency subtraction plus ratio analysis of means. Cytometry 2001;43:55-68.
4. Young IT: Proof without prejudice: use of the Kolmogorov-Smirnov test for the analysis of histograms from flow systems and other sources. J Histochem Cytochem 1977;25:935-941.
5. Lampariello F: On the use of the Kolmogorov-Smirnov statistical test for immunofluorescence histogram comparison. Cytometry 2000;39:179-188.
6. Eudey TL: Statistical considerations in DNA flow cytometry. Stat Sci 1996;11:320-334.
7. Vindelov LL, Christensen IJ: A review of techniques and results obtained in one laboratory by an integrated system of methods designed for routing clinical flow cytometric DNA analysis. Cytometry 1990;11:753-770.
8. Gasparri F: Multiparametric cell cycle analysis by automated microscopy. J Biomol Screen 2006;11:586-598.
9. Mann RC, Hand RE Jr, Braslawsky GR: Parametric analysis of histograms measured in flow cytometry. Cytometry 1983;4:75-82.
10. Baldetorp B, Dalberg M, Holst U, Lindgren G: Statistical evaluation of cell kinetic data from DNA flow cytometry (FCM) by the EM algorithm. Cytometry 1989;10:695-705.
11. Diaz-Frances E, Sprott DA: Statistical analysis of nuclear genome size of plants with flow cytometer data. Cytometry 2001;45:244-249.
12. Gibbons JD: Nonparametric Methods for Quantitative Analysis, 3rd ed. American Sciences Press, Columbus, OH, 1997.
13. rd ed. John Wiley & Sons, New York, 1999.
14. Scott DW: Multivariate Density Estimation. Theory, Practice, and Visualization. John Wiley and Sons, New York, 1992.
15. rd ed. Springer-Verlag, New York, 1999.
16. Cellomics: Cellomics HCS Reader: Target Activation BioApplication Guide (V2 version). Cellomics, Pittsburgh, PA. Available at: http://www.cellomics.com. Last accessed March 2007.