Post-remission Treatment for Adult Patients With Acute Lymphoblastic Leukemia in First Remission: Is There a Role for Autologous Stem Cell Transplantation?

Seminars in Hematology

Volumn 44, Issue 4, 2007, Pages 267-273

  Willemze, Roel ^a   Labar, Boris ^b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b KBC Zagreb   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; ASPARAGINASE; DEXAMETHASONE; IMATINIB; INTERLEUKIN 2; METHOTREXATE; MONOCLONAL ANTIBODY; PREDNISONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CANCER CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER REGRESSION; CANCER RISK; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CYTOGENETICS; DRUG MEGADOSE; HUMAN; IMMUNOPHENOTYPING; INTERMETHOD COMPARISON; MAINTENANCE THERAPY; NONMYELOABLATIVE CONDITIONING; ORGAN DONOR; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; EVIDENCE-BASED MEDICINE; HUMANS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REMISSION INDUCTION; STEM CELL TRANSPLANTATION; SURVIVAL RATE; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; WHOLE-BODY IRRADIATION;

EID: 35348991081     PISSN: 00371963     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2007.08.004     Document Type: Article

References (23)

1. Bassan R., Gatta G., Tondini C., and Willemze R. Adult acute lymphoblastic leukaemia. Crit Rev Oncol/Hematol 50 (2004) 223-261
2. Goekbuget N., and Hoelzer D. Treatment of adult acute lymphoblastic leukemia. ASH Educational Program Book (2006) 133-142
3. Wassmann B., Pfeifer H., Goekbuget N., Beelen D.W., Beck J., Stelljes M., et al. Alternating verus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia. Blood 109 (2006) 1469-1477
4. Bruggemann M., Raff T., Flohr T., Goedbuget N., Nakao M., Droese J., et al. Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia. Blood 107 (2006) 1116-1123
5. Suciu S., Mandelli F., de Witte T., Zittoun R., Gallo E., Labar B., et al. Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission: Intention-to-treat analysis of the EORTC/GIMEMA AML-10 trial. Blood 102 (2003) 1232-1240
6. Yanada M., Matsuo K., Suzuki T., and Naoe T. Allogeneic hematopoietic stem cell transplantation as part of postremission therapy improves survival for adult patients with high risk acute lymphoblastic leukemia: A meta-analysis. Cancer 106 (2006) 2657-2663
7. Fiere D., Lepage E., Sebban C., Boucheix C., Gisselbrecht C., Vernant J.P., et al. French Group on Therapy for Adult Acute Lymphoblastic Leukemia. Adult acute lymphoblastic leukemia: A multicentric randomized trial testing bone marrow transplantation as postremission therapy. J Clin Oncol 11 (1993) 1990-2001
8. Thomas X., Boiron J.M., Huguet F., Dombret H., Bradstock K., Vey N., et al. Outcome of treatment in adults with acute lymphoblastic leukemia: Analysis of the LALA-94 trial. J Clin Oncol 22 (2004) 4075-4086
9. Hunault M., Harousseau J.L., Delain M., Truchan-Graczyk M., Cahn J.Y., Witz F., et al. Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high dose therapy and autologous BMT: A GOELAMS trial. Blood 104 (2005) 3028-3037
10. Labar B., Suciu S., Zittoun R., Muus P., Marie J.P., Peetermans M., et al. Allogeneic stem cell transplantation in acute lymphoblastic leukemia for patients <50 years in first complete remission: Results of the EORTC ALL-3 trial. Haematologica 89 (2004) 809-817
11. Ribera J.M., Oriol A., Bethencourt C., Parody R., Hernandez-Rivas J.M., Moreno M.J., et al. Comparison of intensive chemotherapy, allogeneic or autologous stem cell transplantation as post-remission treatment for adult patients with high-risk acute lymphoblastic leukemia. Results of the PETHEMA ALL-93 trial. Haematologica 90 (2005) 1346-1356
12. Cornelissen J.J. Current developments in the treatment of acute lymphoblastic leukemia in adults. Bone Marrow Transplant 37 (2006) 247
13. Labar B, Suciu S, Muus P, Willemze R, Marie JP, Fillet G, et al: Stem cell transplantation in adult ALL: A donor versus no donor comparison in the EORTC ALL-4 study. Leuk Res (in press)
14. Rowe J.M., Buck G., Fielding A., Tallman M.S., Burnett A.K., Chopra R., et al. In adults with standard-risk ALL the greatest benefit is achieved from an allogeneic transplant in first remission and an autologous transplant is less effective than conventional consolidation/maintenance chemotherapy: Final results of the international ALL trial (MRC UKALL XII/ECOG E2993). Blood 108 (2006) 5a (abstr)
15. Mato A.R., and Luger S.M. Autologous stem cell transplant in ALL: Who should we be transplanting in first remission?. Bone Marrow Transplant 37 (2006) 989-995
16. Thiebaut A., Vernant J.P., Degos L., Huguet F.R., Reiffers J., Sebban C., et al. Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA87. Hematol Oncol Clin North Am 14 (2000) 1353-1366
17. Dhedin N., Dombret H., Thomas X., Lheritier V., Boiron J.M., Rigal-Huguet F., et al. Autologous stem cell transplantation in adults with acute lymphoblastic leukemia in first complete remission: Analysis of the LALA-85, -87, -94 trials. Leukemia 20 (2006) 336-344
18. Dombret H., Gabert J., Boiron J.M., Rigal-Huguet F., Blaise D., Thomas X., et al. Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia-Results of the prospective multicenter LALA-94 trial. Blood 100 (2002) 2357-2366
19. Rowe J.M., Buck G., Burnett A.K., Chopra R., Wiernik P.H., Richards S.M., et al. Induction therapy for adults with acute lymphoblastic leukemia: Results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993. Blood 106 (2005) 3760-3767
20. Goldstone A.H., Chopra R., Buck G., Richards M., Franklin I.M., Lazarus H.M., et al. The outcome of 267 Philadelphia positive adults in the international UKALL XII/ECOG E2993 study. Final analysis and role of allogeneic transplant in those under 50 years. Blood 102 (2003) 80a (abstr)
21. Doney K., Buckner C.D., Fisher L., Petersen F.B., Sanders J., Appelbaum F.R., et al. Autologous bone marrow transplantation for acute lymphoblastic leukemia. Bone Marrow Transplant 12 (1993) 315-321
22. Egerer G., Goldschmidt H., Zoz M., and Ho A.D. Autologous bone marrow transplantation in adult patients with acute lymphoblastic leukemia. Leuk Lymphoma 44 (2003) 9-14
23. Granena Batista A., and Ferra Coll C. Autologous stem cell transplantation and purging in adult acute lymphoblastic leukemia. Best Pract Res Clin Hematol 15 (2003) 675-693