Shedding new light on false positive diagnosis of trisomy 21 by fluorescence in situ hybridization (FISH) on uncultured amniotic fluid cells: Experiences from two Canadian cytogenetic laboratories

Prenatal Diagnosis

Volumn 27, Issue 10, 2007, Pages 964-966

  Wang, Jia Chi ^a,b   Bowser, Kathy ^c,d   Chernos, Judy ^c,d  

^a HAMILTON REGIONAL LABORATORY MEDICINE PROGRAM   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c ALBERTA CHILDREN'S HOSPITAL   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

Contamination; False positive; Interphase fish; Trisomy 21

Indexed keywords

AMNIOTIC FLUID CELL; AORTA DISEASE; ARTICLE; CHOROID PLEXUS; CHROMOSOME 21; CHROMOSOME ANALYSIS; CYST; ECHOGRAPHY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; INTRAUTERINE GROWTH RETARDATION; KARYOTYPE; LABORATORY; LABORATORY DIAGNOSIS; MULTICYSTIC DYSPLASTIC KIDNEY; OLIGOHYDRAMNIOS; PREGNANCY; PRIORITY JOURNAL; TRISOMY 21;

ADULT; ALBERTA; AMNIOTIC FLUID; DOWN SYNDROME; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT, NEWBORN; MALE; ONTARIO; PREGNANCY; PREGNANCY TRIMESTER, SECOND; PRENATAL DIAGNOSIS;

EID: 35348974597     PISSN: 01973851     EISSN: 10970223     Source Type: Journal    
DOI: 10.1002/pd.1795     Document Type: Article

References (4)

1. George AM, Oei P, Winship I. 2003. False-positive diagnosis of trisomy 21 using fluorescence in situ hybridisation (FISH) on uncultured amniotic fluid cells. Prenat Diagn 23: 302-305.
2. Tepperberg J, Pettenati MJ, Rao PN, et al. 2001. Prenatal diagnosis using interphase fluorescence in situ hybridization (FISH): 2-year multi-center retrospective study and review of the literature. Prenat Diagn 21: 293-301.
3. Weremowicz S, Sandstrom DJ, Morton CC, Niedzwiecki CA, Sandstrom MM, Bieber FR. 2001. Fluorescence in situ hybridization (FISH) for rapid detection of aneuploidy: experience in 911 prenatal cases. Prenat Diagn 21: 262-269.
4. Witters I, Devriendt K, Legius E, et al. 2002. Rapid prenatal diagnosis of trisomy 21 in 5049 consecutive uncultured amniotic fluid samples by fluorescence in situ hybridisation (FISH). Prenat Diagn 22: 29-33.