Survival and recurrent disease after postoperative radiotherapy for early endometrial cancer: Systematic review and meta-analysis

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 114, Issue 11, 2007, Pages 1313-1320

  Johnson, N ^a   Cornes, P ^a  

^a ROYAL UNITED HOSPITAL   (United Kingdom)

Author keywords

Clinical trial; Disease free interval; Endometrial cancer; Meta analysis; Radiotherapy; Randomised trial; Survival; Systematic review; Uterine cancer

Indexed keywords

CANCER ADJUVANT THERAPY; CANCER PREVENTION; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER RISK; CANCER SURVIVAL; CLINICAL TRIAL; COCHRANE LIBRARY; COHORT ANALYSIS; CONFIDENCE INTERVAL; DISEASE FREE SURVIVAL; EARLY CANCER; ENDOMETRIUM CANCER; EXTERNAL BEAM RADIOTHERAPY; HIGH RISK PATIENT; HUMAN; HYSTERECTOMY; META ANALYSIS; METASTASIS; OVERALL SURVIVAL; PELVIS; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RECURRENT CANCER; REVIEW; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SALVAGE THERAPY; SYSTEMATIC REVIEW; TREATMENT RESPONSE; TUMOR DIFFERENTIATION;

ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; NEOPLASM RECURRENCE, LOCAL; POSTOPERATIVE CARE; RADIOTHERAPY, ADJUVANT; RANDOMIZED CONTROLLED TRIALS; RISK FACTORS; SURVIVAL ANALYSIS;

EID: 35348963090     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2007.01332.x     Document Type: Review

References (41)

1. Bray F, Dos Santos Silva I, Moller H, Weiderpass E. Endometrial cancer incidence trends in Europe: underlying determinants and prospects for prevention. Cancer Epidemiol Biomarkers Prev 2005 14 : 1132 42.
2. Bray F, Loos AH, Oostindier M, Weiderpass E. Geographic and temporal variations in cancer of the corpus uteri: incidence and mortality in pre- and postmenopausal women in Europe. Int J Cancer 2005 117 : 123 31.
3. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, 2001. CA Cancer J Clin 2001 51 : 13 36.
4. Boyd L, Cancer Research UK. Survival rates improving for cancer of the womb but its incidence climbs in the over 60s. E-publication. 7 February 2006 www.info.cancerresearchuk.org/news/pressreleases/2006/february/95727 Accessed 17 March 2007.
5. Morrow CP, Bundy BN, Kurman RJ, Creasman WT, Heller P, Homesley HD, et al. Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a Gynecologic Oncology Group study. Gynecol Oncol 1991 40 : 55 65.
6. Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study. Cancer 1987 60 (Suppl 8 2035 41.
7. Small W Jr., Erickson B, Kwakwa F. American Brachytherapy Society survey regarding practice patterns of postoperative irradiation for endometrial cancer: current status of vaginal brachytherapy. Int J Radiat Oncol Biol Phys 2005 63 : 1502 7.
8. Fanning J, Hoffman ML, Andrews SJ, Harrah AW, Feldmeier JJ. Cost-effectiveness analysis of the treatment for intermediate risk endometrial cancer: postoperative brachytherapy vs. observation. Gynecol Oncol 2004 93 : 632 6.
9. Lee CM, Szabo A, Shrieve DC, Macdonald OK, Gaffney DK. Frequency and effect of adjuvant radiation therapy among women with stage I endometrial adenocarcinoma. JAMA 2006 295 : 389 97.
10. Keys HM, Roberts JA, Brunetto VL, Zaino RJ, Spirtos NM, Bloss JD, et al. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2004 92 : 744 51. [Erratum in Gynecol Oncol 2004;94:241-2].
11. Editorial. GOG99: Ending the controversy regarding pelvic radiotherapy for endometrial cancer. Gynecol Oncol 2004 92 : 740 3.
12. Sagae S. JGOG2033: Randomized phase III trial of whole pelvic radiotherapy vs cisplatin-based chemotherapy in patients with intermediate risk endometrial carcinoma. Meeting: 2005 ASCO Annual Meeting www.asco.org/portal/ site/ASCO/menuitem.34d60f5624ba07fd506fe310ee37a01d/?vgnextoid= 76f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview=abst_detail_view&confID= 34&abstracted=30366 Accessed 17 March 2007.
13. Soderini A, Anchezar JP, Sardi JE. Role of adjuvant radiotherapy (RT) in intermediate risk (1b G2-3-1C) endometriod carcinoma (EC) after extended staging surgery (ESS). Preliminary reports of a randomised trial, Abstract P0147. Int J Gynecol Cancer 2003 13 (Suppl 1 78.
14. Kitchener HC, Redman CW, Swart AMC, Amos CL. ASTEC (Surgery Component): A Study in the Treatment of Endometrial Cancer: A Randomised Trial of Lymphadenectomy in the Treatment of Endometrial Cancer (ISRCTN 16571884). 14th International Meeting of the European Society of Gynaecological Oncology 2005 Sep 28 Istanbul.
15. Scholten AN, van Putten WL, Beerman H, Smit VT, Koper PC, Lybeert ML, et al. Postoperative radiotherapy for Stage 1 endometrial carcinoma: long-term outcome of the randomized PORTEC trial with central pathology review. Int J Radiat Oncol Biol Phys 2005 63 : 834 8.
16. Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Warlam-Rodenhuis CC, et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. Post Operative Radiation Therapy in Endometrial Carcinoma. (PORTEC) Study Group. Lancet 2000 355 : 1404 11.
17. Aalders J, Abeler V, Kolstad P, Onsrud M. Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients. Obstet Gynecol 1980 56 : 419 27.
18. Weigensberg IJ. Preoperative radiation therapy in stage I endometrial adenocarcinoma. II. Final report of a clinical trial. Cancer 1984 53 : 242 7.
19. The Cochrane Library on Wiley InterScience user guide version 1.1 www3.interscience.wiley.com/aboutus/sharedfiles/cochrane_transition/ TCLUserGuide_v1_1.zip Accessed 17 March 2007.
20. Kong A, Collingwood M, Simera I, Williams C, Kitchener H. Adjuvant radiotherapy for Stage I endometrial cancer (Protocol). Cochrane Database Syst Rev 2001 2: CD003916.
21. Higgins JPT, Green S, editors. Cochrane Handbook for systematic reviews of interventions 4.2.5 updated May 2005 www.cochrane.dk/cochrane/handbook/hbook. htm Accessed 17 March 2007.
22. Manheimer E, Dickensin K. Locating and selecting studies. In : Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions 4.2.5 updated 2002 www.cc-ims.net/RevMan/download.htm Accessed 17 March 2007.
23. Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Warlam-Rodenhuis CC, et al. The morbidity of treatment for patients with Stage I endometrial cancer: results from a randomized trial. Int J Radiat Oncol Biol Phys 2001 51 : 1246 55.
24. Creutzberg CL. Survival after relapse in patients with endometrial cancer: results from a randomized trial; author reply. Gynecol Oncol 2004 92 : 384 6.
25. Jolly S, Vargas C, Kumar T, Weiner S, Brabbins D, Chen P, et al. Vaginal brachytherapy alone: an alternative to adjuvant whole pelvis radiation for early stage endometrial cancer. Gynecol Oncol 2005 97 : 887 92.
26. Lybeert ML, van-Putten WL, Brölmann HA, Coebergh JW. Postoperative radiotherapy for endometrial carcinoma. Stage I. Wide variation in referral patterns but no effect on long-term survival in a retrospective study in the southeast Netherlands. Eur J Cancer 1998 34 : 586 90.
27. Einhorn N, Trope C, Ridderheim M, Boman K, Sorbe B, Cavallin-Stahl E. A systematic overview of radiation therapy effects in uterine cancer (corpus uteri). Acta Oncol 2003 42 : 557 61.
28. Lee CM, Szabo A, Shrieve DC, Gaffney DK. Adjuvant radiation provides a survival advantage for specific patient cohorts with stage 1 endometrial carcinoma: a surveillance epidemiology and end results (SEER) population analysis. Int J Radiat Oncol Biol Phys 2005 63 (Suppl 2 S98.
29. Solhjem MC, Petersen IA, Haddock MG. Vaginal brachytherapy alone is sufficient adjuvant treatment of surgical stage I endometrial cancer. Int J Radiat Oncol Biol Phys 2005 62 : 1379 84.
30. Sorbe B, Straumits A, Karlsson L. Intravaginal high-dose-rate brachytherapy for stage I endometrial cancer: a randomized study of two dose-per-fraction levels. Int J Radiat Oncol Biol Phys 2005 62 : 1385 9.
31. Fanning J, Nanavati PJ, Hilgers RD. Surgical staging and high dose rate brachytherapy for endometrial cancer: limiting external radiotherapy to node-positive tumors. Obstet Gynecol 1996 87 : 1041 4.
32. Horowitz NS, Peters WA 3rd., Smith MR, Drescher CW, Atwood M, Mate TP. Adjuvant high dose rate vaginal brachytherapy as treatment of stage I and II endometrial carcinoma. Obstet Gynecol 2002 99 : 235 40.
33. Ng TY, Perrin LC, Nicklin JL, Cheuk R, Crandon AJ. Local recurrence in high-risk node-negative stage I endometrial carcinoma treated with postoperative vaginal vault brachytherapy. Gynecol Oncol 2000 79 : 490 4.
34. Alektiar KM, McKee A, Venkatraman E, McKee B, Zelefsky MJ, Mychalczak BR, et al. Intravaginal high-dose-rate brachytherapy for Stage IB (FIGO Grade 1, 2) endometrial cancer. Int J Radiat Oncol Biol Phys 2002 53 : 707 13.
35. Postoperative radiation therapy for endometrial carcinoma - a multicenter randomised phase III trial comparing external beam irradiation and vaginal brachytherapy www.ikcnet.nl/trials/index.php?id=79 Accessed 17 March 2007.
36. NCIC-Clinical Trials Group (CAN-NCIC-EN5, NCT00002807, NCI-V96-0945) phase III randomized study of pelvic radiotherapy versus observation after laparoscopically-assisted vaginal hysterectomy or total abdominal hysterectomy in patients with intermediate-risk endometrial cancer www.clinicaltrials.gov/ show/NCT00002807 Accessed 17 March 2007.
37. ASTEC: A study in the treatment of endometrial cancer www.ctu.mrc.ac.uk/studies/ASTEC.asp Accessed 17 March 2007.
38. Jhingran A, Burke TW, Eifel PJ. Definitive radiotherapy for patients with isolated vaginal recurrence of endometrial carcinoma after hysterectomy. Int J Radiat Oncol Biol Phys 2003 56 : 1366 72.
39. Jackson S, Murdoch J, Howe K, Bedford C, Sanders T, Prentice A. The management of cervical carcinoma within the south west region of England. Expert Tumour Panel. Br J Obstet Gynaecol 1997 104 : 140 4.
40. Kitchener H. ASTEC. British Gynaecological Cancer Society Autumn Meeting Leeds. 10 November 2005.
41. Kitchener H. State of the Art Session: Endometrial Cancer. How and Who Should We Stage With Early Endometrial Carcinoma? Eleventh Biennial Meeting of the International Gynecologic Cancer Society 2006 Oct 15 Santa Monica, California. 2006.