A simple and efficient catalyst system for the asymmetric transfer hydrogenation of ketones

Synlett

Volumn , Issue 16, 2007, Pages 2541-2544

  Ahlford, Katrin ^a   Zaitsev, Alexey B ^a   Ekström, Jesper ^a   Adolfsson, Hans ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Asymmetric catalysis; Hydrogen transfer; Ketones; Reductions; Rhodium

Indexed keywords

2 PROPANOL; ACETOPHENONE; AMINO ACID; HYDROXAMIC ACID; KETONE DERIVATIVE; LIGAND; RHODIUM;

ARTICLE; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; HYDROGENATION; STEREOCHEMISTRY;

EID: 35348962716     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-986653     Document Type: Article

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47. 2] (0.0025 mmol), ligand (0.0055 mmol), and LiCl (0.05 mmol) were dried under vacuum in a dry Schlenk tube for 15 min. Ketone (1 mmol), i-PrOH (4.5 mL), and a 0.01 M solution of i-PrONa in i-PrOH (0.5 mL, 5 mol%) were added under nitrogen. The reaction mixture was stirred at ambient temperature. Aliquots were taken after the reaction times indicated in Tables 1 and 2 and were then passed through a pad of silica with EtOAc as the eluent. The resulting solutions were analyzed by GLC (CP Chirasil DEXCB).
48. Turnover frequencies determined after 30 min reaction time.