Effects of metoprolol on β1 adrenergic receptor polymorphism and receptor density in urban Chinese patients with heart failure

Chinese Medical Journal

Volumn 120, Issue 19, 2007, Pages 1720-1723

  Luo, Ming ^a   Bi, Ying ^a   Xu, Yuan Xi ^a  

^a TONGJI UNIVERSITY   (China)

Author keywords

Chronic heart failure; Metoprolol; Polymorphism; Receptor density; adrenergic receptor

Indexed keywords

ARGININE; BETA 1 ADRENERGIC RECEPTOR; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GLYCINE; METOPROLOL; SERINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ADULT; AGED; ARTICLE; CHINESE; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG EFFECT; DRUG RESPONSE; FEMALE; GENETIC VARIABILITY; GENOTYPE; GEOMETRY; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART SIZE; HUMAN; MAJOR CLINICAL STUDY; MALE; RECEPTOR DENSITY; SINGLE NUCLEOTIDE POLYMORPHISM; URBAN AREA; GENETICS; HEART LEFT VENTRICLE FUNCTION; MIDDLE AGED; PATHOPHYSIOLOGY;

ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENOTYPE; HEART FAILURE; HUMANS; MALE; METOPROLOL; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, BETA-1; VENTRICULAR FUNCTION, LEFT;

EID: 35348959598     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200710010-00016     Document Type: Article

References (7)

1. Terra SG, Pauly DF, Lee CR, Patterson JH, Adams KF, Schofield RS, et al. Beta-adrenergic receptor polymorphisms and responses during titration of metoprolol controlled release/extended release in heart failure. Clin Pharmacol Ther 2005; 77: 127-137.
2. White HL, de Boer RA, Maqbool A, Greenwood D, van Veldhuisen DJ, Cuthbert R, et al. An evaluation of the beta-1 adrenergic receptor Arg3PGly polymorphism in individuals with heart failure: a MERIT-HF sub-study. Eur J Heart Fail 2003; 5: 463-468.
3. Gilbert EM, Olsen SL, Renlund OG, Bristow MR. Beta-adrenergic receptor regulation and left ventricular function in idiopathic dilated cardiomyopathy. Am J Cardiol 1993; 71: 23C-29C.
4. Zhang XL, Xu B, Feng Y. Effects of diltiazem on down-regulation of lymphocyte beta-adrenoceptors in patients with chronic congestive heart failure. Acta Pharmacol Sin 2000; 21: 927-930.
5. Kass DA. Beta-receptor polymorphisms: heart failure's crystal ball. Nat Med 2003; 9: 1260-1262.
6. Mason DA, Moore JD, Green SA, Liggett SB. A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. J Biol Chem 1999; 274: 12670-12674.
7. Magnusson Y, Levin MC, Eggertsen P, Nyström E, Mobini R, Schaufelberger M, et al. Ser49Gly of beta1-adrenergic receptor is associated with effective beta-blocker dose in dilated cardiomyopathy. Clin Pharmacol Ther 2005; 78: 221-231.