Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-Fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate

ChemBioChem

Volumn 8, Issue 15, 2007, Pages 1826-1833

  Faraldos, Juan A ^a   Zhao, Yuxin ^a,b   O'Maille, Paul E ^c   Noel, Joseph P ^c   Coates, Robert M ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b Takeda San Diego Inc   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Biosynthesis; Carbocations; Enzyme catalysis; Farnesyl diphosphate; Fluorine; Terpenoids

Indexed keywords

1 FLUOROGERMACRENE A; 5 EPI ARISTOLOCHENE; 6 FLUOROFARNESYL DIOPHOSPHATE; ALKADIENE; ARISTOLOCHENE; FARNESYL DIPHOSPHATE; FLUOROCYCLODECADIENE; PYROPHOSPHATE; TERPENOID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CYCLIZATION; ENZYME DEGRADATION; INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STEADY STATE; ULTRAVIOLET SPECTROSCOPY;

ALKYL AND ARYL TRANSFERASES; BINDING SITES; CATALYSIS; CHROMATOGRAPHY; CYCLIZATION; HYDROCARBONS, FLUORINATED; KINETICS; MODELS, CHEMICAL; POLYISOPRENYL PHOSPHATES; SESQUITERPENES; SESQUITERPENES, GERMACRANE; SPECTRUM ANALYSIS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TOBACCO;

NICOTIANA TABACUM;

EID: 35348952662     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700398     Document Type: Article

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