P-Glycoprotein has negligible effects on estradiol and testosterone in mice

Neuroscience Letters

Volumn 427, Issue 1, 2007, Pages 6-9

  Ebinger, Martin ^a   Behl, Christian ^b   Rosenhagen, Marcus ^a   Uhr, Manfred ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Abcb1ab; Estradiol; Knock out mice; P Glycoprotein; Testosterone

Indexed keywords

ESTRADIOL; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; TESTOSTERONE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; HORMONE TRANSPORT; IN VITRO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN CHEMISTRY; ESTRADIOL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; P-GLYCOPROTEIN; PITUITARY GLAND; RADIOLIGAND ASSAY; TESTOSTERONE; TRITIUM; VISCERA;

EID: 35348952146     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.06.042     Document Type: Article

References (29)

1. Arceci R.J., Baas F., Raponi R., Horwitz S.B., Housman D., and Croop J.M. Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus. Mol. Reprod. Dev. 25 (1990) 101-109
2. Behl C. Oestrogen as a neuroprotective hormone. Nat. Rev. Neurosci. 3 (2002) 433-442
3. Behl C. Estrogen can protect neurons: modes of action. J. Steroid Biochem. Mol. Biol. 83 (2002) 195-197
4. Behl C., and Moosmann B. Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compounds. Biol. Chem. 383 (2002) 521-536
5. Bhasin S., Gabelnick H.L., Spieler J.M., Swerdloff R.S., Wang C., and Kelly C. Pharmacology, Biology, and Clinical Applications of Androgens (1996), Wiley-Liss, New York
6. Dey S., Gunda S., and Mitra A.K. Pharmacokinetics of Erythromycin in rabbit corneas following single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption. J. Pharmacol. Exp. Ther. 311 (2004) 246-255
7. Dey S., Patel J., Anand B.S., Jain-Vakkalagadda B., Kaliki P., Pal D., Ganapathy V., and Mitra A.K. Molecular evidence and functional expression of P-glycoprotein (MDR1) in human and rabbit cornea and corneal epithelial cell lines. Invest. Ophthalmol. Vis. Sci. 44 (2003) 2909-2918
8. Ebinger M., and Uhr M. ABC drug transporter at the blood-brain barrier. Eur. Arch. Psychiatry Clin. Neurosci. 256 (2006) 294-298
9. Edelmann H.M., Duchek P., Rosenthal F.E., Foger N., Glackin C., Kane S.E., and Kuchler K. Cmdr1, a chicken P-glycoprotein, confers multidrug resistance and interacts with estradiol. Biol. Chem. 380 (1999) 231-241
10. Fojo A.T., Ueda K., Slamon D.J., Poplack D.G., Gottesman M.M., and Pastan I. Expression of a multidrug-resistance gene in human tumors and tissues. Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 265-269
11. Fujise H., Annoura T., Sasawatari S., Ikeda T., and Ueda K. Transepithelial transport and cellular accumulation of steroid hormones and polychlorobiphenyl in porcine kidney cells expressed with human P-glycoprotein. Chemosphere 46 (2002) 1505-1511
12. Goodenough S., Schleusner D., Pietrzik C., Skutella T., and Behl C. Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes. Neuroscience 132 (2005) 581-589
13. Hamilton K.O., Yazdanian M.A., and Audus K.L. Modulation of P-glycoprotein activity in Calu-3 cells using steroids and beta-ligands. Int. J. Pharm. 228 (2001) 171-179
14. Huang L., Hoffman T., and Vore M. Adenosine triphosphate-dependent transport of estradiol-17beta (beta-d-glucuronide) in membrane vesicles by MDR1 expressed in insect cells. Hepatology 28 (1998) 1371-1377
15. Joels M., and de Kloet E.R. Control of neuronal excitability by corticosteroid hormones. Trends Neurosci. 15 (1992) 25-30
16. Kim W.Y., and Benet L.Z. P-Glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm. Res. 21 (2004) 1284-1293
17. Liu Y., Huang L., Hoffman T., Gosland M., and Vore M. MDR1 substrates/modulators protect against beta-estradiol-17beta-d-glucuronide cholestasis in rat liver. Cancer Res. 56 (1996) 4992-4997
18. Manthey D., and Behl C. From structural biochemistry to expression profiling: Neuroprotective activities of estrogen. Neuroscience 138 (2006) 845-850
19. McEwen B. Invited review: estrogens effects on the brain: multiple sites and molecular mechanisms. J. Appl. Physiol. 91 (2001) 2785-2801
20. Müller M.B., Keck M.E., Binder E.B., Kresse A.E., Hagemeyer T.P., Landgraf R., Holsboer F., and Uhr M. ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder. Neuropsychopharmacology 28 (2003) 1991-1999
21. Naito M., Yusa K., and Tsuruo T. Steroid hormones inhibit binding of vinca alkaloid to multidrug resistance related P-glycoprotein. Biochem. Biophys. Res. Commun. 158 (1989) 1066-1071
22. Rustay N.R., Wahlsten D., and Crabbe J.C. Assessment of genetic susceptibility to ethanol intoxication in mice. PNAS 100 (2003) 2917-2922
23. Schinkel A.H., Smit J.J., van Tellingen O., Beijnen J.H., Wagenaar E., van Deemter L., Mol C.A., van der Valk M.A., Robanus-Maandag E.C., te Riele H.P., Berns A.J.M., and Borst P. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77 (1994) 491-502
24. Sherwin B.B. Estrogen and cognitive aging in women. Neuroscience 138 (2006) 1021-1026
25. Thiebaut F., Tsuruo T., Hamada H., Gottesman M.M., Pastan I., and Willingham M.C. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 7735-7738
26. Uhr M., Holsboer F., and Müller M.B. Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins. J. Neuroendocrinol. 14 (2002) 753-759
27. Yaffe K. Testosterone and the brain: uncharted territory. Lancet Neurol. 3 (2004) 270
28. Yamamoto Y., Manyon A., Kirdani R.Y., and Sandberg A.A. Androgen metabolism in the rhesus monkey. Steroids 31 (1978) 711-729
29. Zampieri L., Bianchi P., Ruff P., and Arbuthnot P. Differential modulation by estradiol of P-glycoprotein drug resistance protein expression in cultured MCF7 and T47D breast cancer cells. Anticancer Res. 22 (2002) 2253-2259