Hepatocellular injury of nonischemic liver tissue after selective clamping in rats - Protective action by pharmacological pretreatment with lipoic acid

European Surgical Research

Volumn 39, Issue 6, 2007, Pages 325-331

  Duenschede, F ^a   Westermann, S ^a   Miesner, I ^a   Albrecht Schock S ^a   Kneist, W ^a   Korenkov, M ^a   Schad, A ^a   Dutkowski, Ph ^c   Kiemer, A K ^b   Junginger, T ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Hepatic injury; Lipoic acid; Nonischemic liver lobe

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 8; GLUTATHIONE; GLUTATHIONE TRANSFERASE ALPHA; PROTEIN BAX; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN NORWAY RAT; CLAMP; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; INFERIOR CAVA VEIN; LIPID PEROXIDATION; LIVER; LIVER CELL; LIVER CELL DAMAGE; LIVER NECROSIS; LIVER PROTECTION; LIVER SINUSOID; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION;

ANIMALS; ANTIOXIDANTS; CONSTRICTION; DISEASE MODELS, ANIMAL; ISCHEMIA; LIPID PEROXIDATION; LIVER; LIVER DISEASES; MALE; RATS; REPERFUSION INJURY; THIOCTIC ACID;

EID: 35348940214     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000104727     Document Type: Article

References (24)

1. Serracino-Ingloo F, Habib NA, Mathie RT: Hepatic ischemia-reperfusion injury. Am J Surg 2001;181:160-166.
2. Pringle JH: Notes on the arrest of hepatic hemorrhage due to trauma. Ann Surg 1908;48:541-549.
3. Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, Corvera C, Weber S, Blumgart LH: Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg 2002;236:397-406.
4. Selzner N, Rüdiger HA, Graf R, Clavien PA: Protective strategies against ischemic injury of the liver. Gastroenterology 2003;125:917-936.
5. Rüdiger HA, Kang KJ, Sindram D, Riehle HM, Clavien PA: Comparison of ischemic preconditioning and continuous inflow occlusion in the murine liver. Ann Surg 2002;235:400-407.
6. Figueras J, Llado L, Ruiz D, Ramos E, Busquets J, Rafecas A, Torras J, Fabregat J: Complete versus selective portal triad clamping for minor liver resections: a prospective randomized trial. Ann Surg 2005;241:582-590.
7. Malassagne B, Cherqui D, Alon R, Brunetti F, Humeres R, Fagniez PL: Safety of selective vascular clamping for major hepatectomies. J Am Coll Surg 1998;187:482-486.
8. Man K, Lo CM, Ng IO, Wong YC, Quin LF, Fan ST, Wong J: Liver transplantation in rats using small-for-size grafts: a study of hemodynamic and morphological changes. Arch Surg 2001;136:280-285.
9. Clavien PA, Selzner M, Rüdiger HA, Graf R, Kadry Z, Rousson V, Jochum W: A Prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning. Ann Surg 2003;238:843-852.
10. Duenschede F, Westermann S, Riegler N, Ewald P, Kircher A, Schaefer H, Schneider J, Schad A, Junginger T: Different protection mechanisms after pretreatment with glycine or alpha-lipoic acid in a rat model of warm hepatic ischemia. Eur Surg Res 2006;38:503-512.
11. Packer L, Witt EH, Tritschler HJ: Alpha lipoic acid as a biological antioxidant. Free Radic Biol Med 1995;19:227-250.
12. Trautschold I, Lamprecht W, Schweitzer G: ATP: UV-method with hexokinase and glucose-6-phosphate dehydrogenase; in Bergmeyer, et al. (eds): Methods of Enzymatic Analysis, ed 3. New York, Academic Press, 1988, vol 7, pp 346-357.
13. Griffith OW: Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinypyridine. Anal Biochem 1980;106:207-211.
14. Gurtu V, Kain SR, Zahng G: Fluorometric and colorimetric detection of caspase activity associated with apoptosis. Anal Biochem 1997;251:98-102.
15. Amersi F, Buelow R, Kato H, Ke B, Coito AJ, Shen XD, Zhao D, Zaky J, Melinek J, Lassmann CR, Kolls JK, Alam J, Ritter T, Volk HD, Farmer DG, Busuttil RW, Kupiec-Weglinski JW: Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. J Clin Invest 1999;104:1631-1639.
16. Jaeschke H, Farhood A: Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am J Physiol 1991;260:355-362.
17. Han D, Handelmann G, Marcocci L, Sen CK, Roy S, Kobuchi H, Tritschler HJ, Flohe L, Packer L: Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors 1997;6:321-338.
18. Bilzer M, Baron A, Schauer R, Steib C, Ebensberger S, Gerbes AL: Glutathione treatment protects the rat liver against injury after warm ischemia and Kupffer cell activation. Digestion 2002;66:49-57.
19. Dünschede F, Erbes K, Kircher A, Westermann S, Schad A, Riegler N, Ewald P, Dutkowski P, Kiemer AK, Kempski O, Junginger T: Protection from hepatic ischemia/reperfusion injury and improvement of liver regeneration by α-lipoic acid. Shock 2007;27:644-651.
20. Ding WX, Yin XM: Dissection of the multiple mechanisms of TNF-induced apoptosis in liver injury. J Cell Mol Med 2004;8:445-454.
21. Zhao Y, Li S, Childs EE, Kuharsky DK, Yin XM: Activation of pro-death Bcl-2 family and mitochondria apoptosis pathway in tumor necrosis factor alpha induced liver injury. J Biol Chem 2001;276:27432-27440.
22. 2-induced apoptosis of hepatocytes. Int J Mol Med 2003;11:369-374.
23. Jürgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC: Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci 1998;95:4997-5002.
24. Dünschede F, Zwicker K, Ackermann H, Zimmer G: ADP- and oligomycin-sensitive redox behaviour of F0b thiol in ATP-synthase depends on neighbored primary structure: investigation using 14-C-labeled alpha lipoic acid. Biofactors 2003;19:19-32.