Flux control analysis of mitochondrial oxidative phosphorylation in rat skeletal muscle: Pyruvate and palmitoyl-carnitine as substrates give different control patterns

European Journal of Applied Physiology

Volumn 101, Issue 6, 2007, Pages 679-689

  Fritzen, Anette J ^a   Grunnet, Niels ^a   Quistorff, Bjørn ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Flux control; Mitochondria; Oxidative phosphorylation; Skeletal muscle

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE; PALMITOYLCARNITINE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; FEMALE; IN VIVO STUDY; MALE; MITOCHONDRIAL RESPIRATION; MUSCLE METABOLISM; MUSCLE MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; RAT;

ADENOSINE TRIPHOSPHATE; ALGORITHMS; ANIMALS; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; ENERGY METABOLISM; EXERTION; FEMALE; MALE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PALMITOYLCARNITINE; PYRUVIC ACID; RATS; RATS, WISTAR; UNCOUPLING AGENTS;

EID: 35348932862     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-007-0544-2     Document Type: Article

References (53)

1. Bensadoun A, Weinstein D (1976) Assay of proteins in the presence of interfering materials. Anal Biochem 70:241-250
2. Bohnensack R, Küster U, Letko G (1982) Rate-controlling steps of oxidative phosphorylation in rat liver mitochondria. Biochim Biophys Acta 680:271-280
3. Bolli R, Nalecz KA, Azzo A (1989) Monocarboxylate and α-ketoglutarate carriers from bovine heart mitochondria. J Biol Chem 264:18024-18030
4. Brand MD, Hafner RP, Brown GC (1988) Control of respiration in non-phosphorylating mitochondria is shared between the proton leak and the respiratory chain. Biochem J 255:535-539
5. Brand MD, Pakay JL, Ocloo A, Kokoszka J, Wallace DC, Brookes PS, Cornwall EJ (2005) The basal proton conductance of mitochondria depends on adenine nucleotide tranlocase content. Biochem J 392:353-362
6. Coates PM, Tanaka K (1992) Molecular basis of mitochondrial fatty acid oxidation defects. J Lipid Res 33:1099-1110
7. Denton RM, Halestrap AP (1979) Regulation of pyruvate metabolism in mammalian tissues. Essays Biochem 15:37-77
8. Di Paola M, Lorusso M (2006) Interaction of fatty acids with mitochondria: Coupling, uncoupling and permeability transition. Biochim Biophys Acta 1757:1330-1337
9. Eaton S, Bartlett K, Pourfarzam M (1996) Mammalian mitochondrial β-oxidation. Biochem J 320:345-357
10. Eaton S, Middleton B, Sherratt HSA, Pourfarzam M, Quant PA, Bartlett K (1999) In: Quant A, Eaton S (eds) Current views of fatty acid oxidation and ketogenesis. Kluwer, New York, pp 145-154
11. Felig P, Wahren J (1975) Fuel homeostasis in exercise. N Engl J Med 20:1078-1084
12. Ferreira GC, Pedersen PL (1993) Phosphate transport in mitochondria: past accomplishments, present problems, and future challenges. J Bioenerg Biomembr 25:483-492
13. Frayn KN (1996) Metabolic regulation. A human perspective. Portland, London
14. Gellerich FN, Bohnensack R, Kunz W (1983) Control of mitochondrial respiration. The contribution of the adenine nucleotide translocator depends on the ATP- and ADP consuming enzymes. Biochim Biophys Acta 722:381-391
15. Gellerich FN, Kunz WS, Bohnensack R (1990) Estimation of flux control coefficients from inhibitor titrations by non-linear regression. FEBS Lett 274:167-170
16. Gollnick PD (1985) Metabolism of substrates: Energy substrate metabolism during exercise and as modified by training. Fed Proc 44:353-357
17. Groen AK, Wanders RJA, Westerhoff HV, Van Der Meer R, Tager JM (1982) Quantification of the contribution of various steps to the control of mitochondrial respiration. J Biol Chem 257:2754-2757
18. Hafner RP, Brown GC, Brand MD (1990) Analysis of the control of respiration rate, proton leak rate and protonmotive force in isolated mitochondria using the "top-down" approach of metabolic control theory. Eur J Biochem 188:313-319
19. Heinrich R, Rapoport TA (1974) A linear steady-state treatment of enzymatic chains. Eur J Biochem 42:89-95
20. Hirabara SM, Silveira LR, Alberici LC, Leandro CVG, Lambertucci RH, Polimeno GC, Boaventura MFC, Procopio J, Vercesi AE, Curi R (2006) Acute effects of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. Biochim Biophys Acta 1757:57-66
21. Holness MJ, Sugden MC (2003) Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans 31:1143-1151
22. Kacser H (1995) Recent developments beyond metabolic control analysis. Biochem Soc Trans 23:387-391
23. Kascer H, Burns JA (1973) The control of flux. Symp Soc Exp Biol 27:65-104
24. Kiens B, Éssen-Gustavsson B, Christensen NJ, Saltin B (1993) Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J Physiol 469:459-478
25. Korzeniewski B, Mazat JP (1996) Theoretical studies on the control of oxidative phosphorylation in muscle mitochondria: Application to mitochondrial deficiencies. Biochem J 319:143-148
26. Krämer R (1996) Structural and functional aspects of the phosphate carrier from mitochondria. Kidney Int 49:947-952
27. Kunz WS (1991) Application of the theory of steady-state flux control to mitochondrial β-oxidation. Biomed Biochem Acta 50:1143-1157
28. Kunz WS, Kudin A, Vielhaber S, Elger CE, Attardi G, Villani G (2000) Flux control of cytochrome c oxidase in human skeletal muscle. J Biol Chem 275:27741-27745
29. Letellier T, Malgat M, Mazat J-P (1993) Control of oxidative phosphorylation in rat muscle mitochondria; implications for mitochondrial myopathies. Biochim Biophys Acta 1141:58-64
30. i exchange in rat liver mitochondria. Rapid filtration experiments in the millisecond time range. Biochemistry 24:4423-4428
31. Lopaschuk GD, Belke DD, Gamble J, Itoi T, Schönekess BO (1994) Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta 1213:263-276
32. Mokhova EN, Starkov AA, Bobyleva VA (1994) Uncoupling of oxidative phosphorylation by fatty acids in liver and muscle mitochondria. Biochemistry (Moscow) 58:1105-1112
33. 2+ concentrations. J Biol Chem 260:4028-4034
34. Moreno-Sánchez R (1985b) Contribution of the translocator of adenine nucleotides and the ATP synthase to the control of oxidative phosphorylation and arsenylation in liver mitochondria. J Biol Chem 260:12554-12560
35. Moreno-Sánchez R, Torre-Márquez ME (1991) Control of oxidative phosphorylation in mitochondria, cells and tissues. Int J Biochem 23:1163-1174
36. Moreno-Sánchez R, Devars S, López-Gómez F, Uribe A, Corona N (1991) Distribution of control of oxidative phosphorylation in mitochondria oxidizing NAD-linked substrates. Biochim Biophys Acta 1060:284-292
37. Peterson GL (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83:346-356
38. Ponchaut S, Van Hoff F, Veitch K (1992) In vitro effects of valproate and valproate metabolites on mitochondrial oxidations. Biochem Pharmacol 43:2435-2442
39. Piccoli C, Scrima R, Boffoli D, Capitanio N (2006) Control by cytochrome c oxidase of the cellular oxidative phosphorylation system depends on the mitochonddrial energy state. Biochem J 396:573-583
40. Putman CT, Jones NL, Lands LC, Bragg TM, Hollidge-Horvat MG, Heigenhauser JF (1995) Skeletal muscle pyruvate dehydrogenase activity during maximal exercise in humans. Am J Physiol 269:E458-E468
41. Quant PA, Makins RA (1994) Metabolic control analysis of hepatic β-oxidation: The top-down approach. Biochem Soc Trans 22:441-446
42. Rasmussen UF, Rasmussen HN (2000) Human quadriceps muscle mitochondria: a functional characterization. Mol Cell Biochem 208:37-44
43. Rasmussen HN, Andersen AJ, Rasmussen UF (1997) Optimization of preparation of mitochondria from 25-100 mg skeletal muscle. Anal Biochem 252:153-159
44. Sherratt HS, Spurway TD (1994) Regulation of fatty acid oxidation in cells. Biochem Soc Trans 22:423-427
45. Sherratt HS, Watmough NJ, Johnson MA, Turnbull DM (1988) Methods for study of normal and abnormal skeletal muscle mitochondria. Methods Biochem Anal 33:243-335
46. Shepherd D, Garland PB (1969) Citrate synthase from rat liver. Methods Enzymol 13:11-16
47. Small JR (1993) Flux control coefficients determined by inhibitor titration: The design and analysis of experiments to minimize errors. Biochem J 296:423-433
48. Small JR, Kacser H (1993) Responses of metabolic systems to large changes in enzyme activities and effectors. Eur J Biochem 213:613-624
49. Tager JM, Groen AK, Wanders RJA, Duszynski J, Westerhoff HV, Vervoorn RC (1983) Control of mitochondrial respiration. Biochem Soc Trans 11:40-43
50. Wanders RJA, Groen AK, Van Roermund CWT, Tager JM (1984) Factors determining the relative contribution of the adenine-nucleotide translocator and the ADP-regenerating system to the control of oxidative phosphorylation in isolated rat-liver mitochondria. Eur J Biochem 142:417-424
51. Wisniewski E, Kunz WS, Gellerich FN (1993) Phosphate affects the distribution of flux control among the enzymes of oxidative phosphorylation in rat skeletal muscle mitochondria. J Biol Chem 268:9343-9346
52. Wisniewski E, Gellerich FN, Kunz WS (1995) Distribution of flux control among the enzymes of mitochondrial oxidative phosphorylation in calcium-activated saponin-skinned rat musculus soleus fibers. Eur J Biochem 230:549-554
53. Wojtczak L, Schönfeld P (1993) Effect of fatty acids on energy coupling processes in mitochondria. Biochim Biophys Acta 1183:41-57