Peripheral association of a polyprotein precursor form of the RNA-dependent RNA polymerase of Tomato ringspot virus with the membrane-bound viral replication complex

Virology

Volumn 368, Issue 1, 2007, Pages 133-144

  Chisholm, Joan ^a   Zhang, Guangzhi ^b   Wang, Aiming ^b   Sanfaçon, Hélène ^a  

^a SUMMERLAND RESEARCH AND DEVELOPMENT CENTRE   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Comoviridae; Membrane association; Nepovirus; Picorna like virus; Positive strand RNA virus; Replication complex; RNA replication; RNA dependent RNA polymerase

Indexed keywords

NUCLEOTIDE BINDING PROTEIN; NUCLEOTIDE TRIPHOSPHATE BINDING PROTEIN; POLYPROTEIN; PROTEINASE; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS ENZYME; VIRUS PROTEIN;

ANTIBODY PRODUCING CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; IMMUNODETECTION; NEPOVIRUS; NONHUMAN; PLANT CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE; TOMATO RINGSPOT VIRUS; VIRUS ENVELOPE; VIRUS REPLICATION;

AMINO ACID SEQUENCE; CUCUMIS SATIVUS; ENDOPLASMIC RETICULUM; GENE PRODUCTS, POL; INTRACELLULAR MEMBRANES; MOLECULAR SEQUENCE DATA; NEPOVIRUS; PEPTIDE HYDROLASES; POLYPROTEINS; PROTEIN STRUCTURE, TERTIARY; RNA REPLICASE; SEQUENCE ALIGNMENT; VIRAL PROTEINS; VIRUS REPLICATION;

COMOVIRIDAE; NEPOVIRUS; PICORNA; RNA VIRUSES; TOMATO RINGSPOT VIRUS;

EID: 35348932680     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2007.06.032     Document Type: Article

References (41)

1. Agol V.I., Paul A.V., and Wimmer E. Paradoxes of the replication of picornaviral genomes. Virus Res. 62 (1999) 129-147
2. Belliot G., Sosnovtsev S.V., Chang K.O., Babu V., Uche U., Arnold J.J., Cameron C.E., and Green K.Y. Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase. J. Virol. 79 (2005) 2393-2403
3. Boguszewska-Chachulska A.M., and Haenni A.L. RNA viruses redirect host factors to better amplify their genome. Adv. Virus Res. 65 (2005) 29-61
4. Carrier K., Hans F., and Sanfacon H. Mutagenesis of amino acids at two tomato ringspot nepovirus cleavage sites: effect on proteolytic processing in cis and in trans by the 3C-like protease. Virology 258 (1999) 161-175
5. Carrington J.C., Haldeman R., Dolja V.V., and Restrepo-Hartwig M.A. Internal cleavage and trans-proteolytic activities of the VPg-proteinase (NIa) of tobacco etch potyvirus in vivo. J. Virol. 67 (1993) 6995-7000
6. Chen J., and Ahlquist P. Brome mosaic virus polymerase-like protein 2a is directed to the endoplasmic reticulum by helicase-like viral protein 1a. J. Virol. 74 (2000) 4310-4318
7. Chisholm J., Wieczorek A., and Sanfacon H. Expression and partial purification of recombinant tomato ringspot nepovirus 3C-like proteinase: comparison of the activity of the mature proteinase and the VPg-proteinase precursor. Virus Res. 79 (2001) 153-164
8. Dorssers L., van der Krol S., vand der Meer J., van Kammen A., and Zabel P. Purification of cowpea mosaic virus RNA replication complex: identification of a virus-encoded 110,000 dalton polypeptide responsible for host chain elongation. Proc. Natl. Acad. Sci. U.S.A. 81 (1984) 1951-1955
9. Demangeat G., Hemmer O., Reinbolt J., Mayo M.A., and Fritsch C. Virus-specific proteins in cells infected with tomato black ring nepovirus: evidence for proteolytic processing in vivo. J. Gen. Virol. 73 (1992) 1609-1614
10. Franco D., Pathak H.B., Cameron C.E., Rombaut B., Wimmer E., and Paul A.V. Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. J. Virol. 79 (2005) 6358-6367
11. Han S., and Sanfacon H. Tomato ringspot virus proteins containing the nucleoside triphosphate binding domain are transmembrane proteins that associate with the endoplasmic reticulum and cofractionate with replication complexes. J. Virol. 77 (2003) 523-534
12. Hans F., and Sanfacon H. Tomato ringspot nepovirus protease: characterization and cleavage site specificity. J. Gen. Virol. 76 (1995) 917-927
13. Hemmer O., Greif C., Dufourcq P., Reinbolt J., and Fritsch C. Functional characterization of the proteolytic activity of the tomato black ring nepovirus RNA-1-encoded polyprotein. Virology 206 (1995) 362-371
14. Jakubiec A., Notaise J., Tournier V., Hericourt F., Block M.A., Drugeon G., van Aelst L., and Jupin I. Assembly of turnip yellow mosaic virus replication complexes: interaction between the proteinase and polymerase domains of the replication proteins. J. Virol. 78 (2004) 7945-7957
15. Koonin E.V., and Dolja V.V. Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences. Crit. Rev. Biochem. Mol. Biol. 28 (1993) 375-430
16. Li X.H., Valdez P., Olvera R.E., and Carrington J.C. Functions of the tobacco etch virus RNA polymerase (NIb): subcellular transport and protein-protein interaction with VPg/proteinase (NIa). J. Virol. 71 (1997) 1598-1607
17. Margis R., Viry M., Pinck M., Bardonnet N., and Pinck L. Differential proteolytic activities of precursor and mature forms of the 24K proteinase of grapevine fanleaf nepovirus. Virology 200 (1994) 79-86
18. Noueiry A.O., and Ahlquist P. Brome mosaic virus RNA replication: revealing the role of the host in RNA virus replication. Annu. Rev. Phytopathol. 41 (2003) 77-98
19. Panavas T., Hawkins C.M., Panaviene Z., and Nagy P.D. The role of the p33:p33/p92 interaction domain in RNA replication and intracellular localization of p33 and p92 proteins of Cucumber necrosis tombusvirus. Virology 338 (2005) 81-95
20. Paul A.V., van Boom J.H., Filippov D., and Wimmer E. Protein-primed RNA synthesis by purified poliovirus RNA polymerase. Nature 393 (1998) 280-284
21. Peters S.A., Voorhorst W.G., Wellink J., and van Kammen A. Processing of VPg-containing polyproteins encoded by the B-RNA from Cowpea mosaic virus. Virology 191 (1992) 90-97
22. Peters S.A., Mesnard J.M., Kooter I.M., Verver J., Wellink J., and van Kammen A. The Cowpea mosaic virus RNA 1-encoded 112 kDa protein may function as a VPg precursor in vivo. J. Gen. Virol. 76 Pt 7 (1995) 1807-1813
23. Puustinen P., and Makinen K. Uridylylation of the potyvirus VPg by viral replicase NIb correlates with the nucleotide binding capacity of VPg. J. Biol. Chem. 279 (2004) 38103-38110
24. Restrepo-Hartwig M.A., and Carrington J.C. The tobacco etch potyvirus 6-kilodalton protein is membrane associated and involved in viral replication. J. Virol. 68 (1994) 2388-2397
25. Roehl H.H., Parsley T.B., Ho T.V., and Semler B.L. Processing of a cellular polypeptide by 3CD proteinase is required for poliovirus ribonucleoprotein complex formation. J. Virol. 71 (1997) 578-585
26. Rott M.E., Gilchrist A., Lee L., and Rochon D. Nucleotide sequence of Tomato ringspot virus RNA1. J. Gen. Virol. 76 (1995) 465-473
27. Salonen A., Ahola T., and Kaariainen L. Viral RNA replication in association with cellular membranes. Curr. Top. Microbiol. Immunol. 285 (2005) 139-173
28. Sanfacon H. Replication of positive-strand RNA viruses in plants: contact points between plant and virus components. Can. J. Bot. 83 (2005) 1529-1549
29. Sanfacon H., Zhang G., Chisholm J., Jafarpour B., and Jovel J. Molecular biology of Tomato ringspot nepovirus, a pathogen of ornamentals, small fruits and fruit trees. In: Teixeira da Silva J. (Ed). Floriculture, Ornamental and Plant Biotechnology: Advances and Topical Issues. 1st Ed. (2006), Global Science Books, London, UK 540-546
30. Schaad M.C., Jensen P.E., and Carrington J.C. Formation of plant RNA virus replication complexes on membranes: role of an endoplasmic reticulum-targeted viral protein. EMBO J. 16 (1997) 4049-4059
31. Schwartz M., Chen J., Janda M., Sullivan M., den Boon J., and Ahlquist P. A positive-strand RNA virus replication complex parallels form and function of retrovirus capsids. Mol. Cell 9 (2002) 505-514
32. Thompson J.D., Higgins D.G., and Gibson T.J. Clustal W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22 (1994) 4673-4680
33. Wang A., and Sanfacon H. Proteolytic processing at a novel cleavage site in the N-terminal region of the tomato ringspot nepovirus RNA-1-encoded polyprotein in vitro. J. Gen. Virol. 81 (2000) 2771-2781
34. Wang A., Carrier K., Chisholm J., Wieczorek A., Huguenot C., and Sanfacon H. Proteolytic processing of tomato ringspot nepovirus 3C-like protease precursors: definition of the domains for the VPg, protease and putative RNA-dependent RNA polymerase. J. Gen. Virol. 80 (1999) 799-809
35. Wang A., Han S., and Sanfacon H. Topogenesis in membranes of the NTB-VPg protein of Tomato ringspot nepovirus: definition of the C-terminal transmembrane domain. J. Gen. Virol. 85 (2004) 535-545
36. Wang X., Lee W.M., Watanabe T., Schwartz M., Janda M., and Ahlquist P. Brome mosaic virus 1a nucleoside triphosphatase/helicase domain plays crucial roles in recruiting RNA replication templates. J. Virol. 79 (2005) 13747-13758
37. Wei L., Huhn J.S., Mory A., Pathak H.B., Sosnovtsev S.V., Green K.Y., and Cameron C.E. Proteinase-polymerase precursor as the active form of feline calicivirus RNA-dependent RNA polymerase. J. Virol. 75 (2001) 1211-1219
38. White K.A., and Nagy P.D. Advances in the molecular biology of tombusviruses: gene expression, genome replication, and recombination. Prog Nucleic Acid Res. Mol. Biol. 78 (2004) 187-226
39. Wienecke K., Glass R., and Robinson D.G. Organelles involved in the synthesis and transport of hydroxyproline-containing glycoproteins in carrot root disks. Planta 155 (1982) 58-63
40. Zhang G., and Sanfacon H. Characterization of membrane-association domains within the Tomato ringspot nepovirus X2 protein, an endoplasmic reticulum-targeted polytopic membrane protein. J. Virol. 80 (2006) 10847-10857
41. Zhang S.C., Zhang G., Yang L., Chisholm J., and Sanfacon H. Evidence that insertion of Tomato ringspot nepovirus NTB-VPg protein in endoplasmic reticulum membranes is directed by two domains: a C-terminal transmembrane helix and an N-terminal amphipathic helix. J. Virol. 79 (2005) 11752-11765