Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 24, 2007, Pages 7720-7725

  Nakamura, Akio ^a   Yamada, Tetsuhiro ^a   Asaki, Tetsuo ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

IP receptor agonist; N Acylsulfonamide; N Acylsulfonylurea; Prodrug; Prostacyclin

Indexed keywords

2 [4 [(5,6 DIPHENYLPYRAZIN 2 YL)(ISOPROPYL)AMINO]BUTOXY] N (2 THIENYLSULFONYL)ACETAMIDE; 2 [4 [(5,6 DIPHENYLPYRAZIN 2 YL)(ISOPROPYL)AMINO]BUTOXY] N (4 MORPHOLINYLSULFONYL)ACETAMIDE; 2 [4 [(5,6 DIPHENYLPYRAZIN 2 YL)(ISOPROPYL)AMINO]BUTOXY] N (ISOPROPYLSULFONYL)ACETAMIDE; 2 [4 [(5,6 DIPHENYLPYRAZIN 2 YL)(ISOPROPYL)AMINO]BUTOXY] N (PHENYLSULFONYL)ACETAMIDE; 2 [4 [(5,6 DIPHENYLPYRAZIN 2 YL)(ISOPROPYL)AMINO]BUTOXY] N (TRIFLUOROMETHANESULFONYL)ACETAMIDE; ANTITHROMBOCYTIC AGENT; N (AMINOSULFONYL) 2 [4 [(5,6 DIPHENYLPYRAZIN 2 YL)(ISOPROPYL)AMINO]BUTOXY]ACETAMIDE; NS 304; PRODRUG; PROSTACYCLIN RECEPTOR; SULFONAMIDE; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG HYDROLYSIS; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME METABOLISM; MALE; MONKEY; NONHUMAN; NORMAL HUMAN; RAT;

ACETAMIDES; ANIMALS; DOGS; DRUG EVALUATION, PRECLINICAL; EPOPROSTENOL; HAPLORHINI; HUMANS; MALE; MICROSOMES; MOLECULAR STRUCTURE; PLATELET AGGREGATION INHIBITORS; PRODRUGS; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, EPOPROSTENOL; SULFONYLUREA COMPOUNDS;

CANIS FAMILIARIS; RATTUS;

EID: 35348922446     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.052     Document Type: Article

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