Renal sympathetic nerves modulate erythropoietin plasma levels after transient hemorrhage in rats

American Journal of Physiology - Renal Physiology

Volumn 293, Issue 4, 2007, Pages

  Ditting, Tilmann ^a   Hilgers, Karl F ^a   Stetter, Alexander ^b   Linz, Peter ^a   Schönweiss, Christina ^a   Veelken, Roland ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Oxygen delivery; Renal nerve

Indexed keywords

ERYTHROPOIETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; CARDIOPULMONARY HEMODYNAMICS; CONTROLLED STUDY; DOPPLER FLOWMETRY; HEMODYNAMICS; KIDNEY NERVE; KIDNEY PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE; VAGOTOMY;

EID: 35348908378     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00267.2007     Document Type: Article

References (43)

1. Bachmann S, Le Hir M, Eckardt KU. Co-localization of erythropoietin mRNA and ecto-5′-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin. J Histochem Cytochem 41: 335-341, 1993.
2. Beru N, McDonald J, Lacombe C, Goldwasser E. Expression of the erythropoietin gene. Mol Cell Biol 6: 2571-2575, 1986.
3. Beynon G. The influence of the autonomic nervous system in the control of erythropoietin secretion in the hypoxic rat. J Physiol 266: 347-360, 1977.
4. Bude RO, Rubin JM. Effect of downstream cross-sectional area of an arterial bed on the resistive index and the early systolic acceleration. Radiology 212: 732-738, 1999.
5. Ditting T, Hilgers KF, Scrogin KE, Linz P, Veelken R. Influence of short-term versus prolonged cardiopulmonary receptor stimulation on renal and preganglionic adrenal sympathetic nerve activity in rats. Basic Res Cardiol 101: 223-234, 2006.
6. Ditting T, Hilgers KF, Scrogin KE, Stetter A, Linz P, Veelken R. Mechanosensitive cardiac C-fiber response to changes in left ventricular filling, coronary perfusion pressure, hemorrhage, and volume expansion in rats. Am J Physiol Heart Circ Physiol 288: H541-H552, 2005.
7. Ditting T, Linz P, Hilgers KF, Jung O, Geiger H, Veelken R. Putative role of epithelial sodium channels (ENaC)in the afferent limb of cardio renal reflexes in rats. Basic Res Cardiol 98: 388-400, 2003.
8. Eckardt KU, Kurtz A, Bauer C. Regulation of erythropoietin production is related to proximal tubular function. Am J Physiol Renal Fluid Electrolyte Physiol 256: F942-F947, 1989.
9. Eckardt KU, LeHir M, Tan CC, Ratcliffe PJ, Kaissling B, Kurtz A. Renal innervation plays no role in oxygen-dependent control of erythropoietin mRNA levels. Am J Physiol Renal Fluid Electrolyte Physiol 263: F925-F930, 1992.
10. Eppel GA, Denton KM, Malpas SC, Evans RG. Nitric oxide in responses of regional kidney perfusion to renal nerve stimulation and renal ischaemia. Pflügers Arch 447: 205-213, 2003.
11. Eppel GA, Lee LL, Evans RG. alpha-Adrenoceptor subtypes mediating regional kidney blood flow responses to renal nerve stimulation. Auton Neurosci 112: 15-24, 2004.
12. Eppel GA, Malpas SC, Denton KM, Evans RG. Neural control of renal medullary perfusion. Clin Exp Pharmacol Physiol 31: 387-396, 2004.
13. Fink GD, Fisher JW. Erythropoietin production after renal denervation or beta-adrenergic blockade. Am J Physiol 230: 508-513, 1976.
14. Fisher JW. Erythropoietin: physiology and pharmacology update. Exp Biol Med (Maywood) 228: 1-14, 2003.
15. Guild SJ, Malpas SC, Eppel GA, Nguang SK, Evans RG. Effect of renal perfusion pressure on responses of intrarenal blood flow to renal nerve stimulation in rabbits. Clin Exp Pharmacol Physiol 31: 35-45, 2004.
16. Hermansson K, Ojteg G, Wolgast M. The cortical and medullary blood flow at different levels of renal nerve activity. Acta Physiol Scand 120: 161-169, 1984.
17. Hogestatt ED, Johansson O, Andersson KE, Kullendorff CM. Influence of renal denervation on vascular responsiveness of isolated rat intrarenal arteries. Acta Physiol Scand 132: 59-66, 1988.
18. Jacobi J, Porst M, Cordasic N, Namer B, Schmieder RE, Eckardt KU, Hilgers KF. Subtotal nephrectomy impairs ischemia-induced angiogenesis and hindlimb re-perfusion in rats. Kidney Int 69: 2013-2021, 2006.
19. Kline RL, Mercer PF. Functional reinnervation and development of supersensitivity to NE after renal denervation in rats. Am J Physiol Regul Integr Comp Physiol 238: R353-R358, 1980.
20. Korner PI, Stokes GS, White SW, Chalmers JP. Role of the autonomic nervous system in the renal vasoconstriction response to hemorrhage in the rabbit. Circ Res 20: 676-685, 1967.
21. Krayacich J, Kline RL, Mercer PF. Supersensitivity to NE alters renal function of chronically denervated rat kidneys. Am J Physiol Renal Fluid Electrolyte Physiol 252: F856-F864, 1987.
22. Krayacich J, Kline RL, Mercer PF. Supersensitivity to norepinephrine in chronically denervated kidneys: evidence for a postsynaptic effect. Can J Physiol Pharmacol 65: 2219-2224, 1987.
23. Langenfeld MR, Veelken R, Schobel HP, Friedrich A, Schmieder RE. Is endogenous erythropoietin a pathogenetic factor in the development of essential hypertension? Nephrol Dial Transplant 12: 1155-1160, 1997.
24. Leonard BL, Malpas SC, Denton KM, Madden AC, Evans RG. Differential control of intrarenal blood flow during reflex increases in sympathetic nerve activity. Am J Physiol Regul Integr Comp Physiol 280: R62-R68, 2001.
25. Lohmeier TE, Reinhart GA, Mizelle HL, Han M, Dean MM. Renal denervation supersensitivity revisited. Am J Physiol Regul Integr Comp Physiol 275: R1239-R1246, 1998.
26. Malpas SC, Evans RG. Do different levels and patterns of sympathetic activation all provoke renal vasoconstriction? J Auton Nerv Syst 69: 72-82, 1998.
27. Maxwell PH, Osmond MK, Pugh CW, Heryet A, Nicholls LG, Tan CC, Doe BG, Ferguson DJ, Johnson MH, Ratcliffe PJ. Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int 44: 1149-1162, 1993.
28. Morrison SF. Differential control of sympathetic outflow. Am J Physiol Regul Integr Comp Physiol 281: R683-R698, 2001.
29. Navakatikyan MA, Leonard BL, Evans RG, Malpas SC. Modelling the neural control of intrarenal blood flow. Clin Exp Pharmacol Physiol 27: 650-652, 2000.
30. O'Connor PM, Kett MM, Anderson WP, Evans RG. Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow. Am J Physiol Renal Physiol 290: F688-F694, 2006.
31. Ramchandra R, Barrett CJ, Guild SJ, Malpas SC. Is the chronically denervated kidney supersensitive to catecholamines? Am J Physiol Regul Integr Comp Physiol 282: R603-R610, 2002.
32. Rosenberger C, Mandriota S, Jurgensen JS, Wiesener MS, Horstrup JH, Frei U, Ratcliffe PJ, Maxwell PH, Bachmann S, Eckardt KU. Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 13: 1721-1732, 2002.
33. Rudenstam J, Bergstrom G, Taghipour K, Gothberg G, Karlstrom G. Efferent renal sympathetic nerve stimulation in vivo. Effects on regional renal haemodynamics in the Wistar rat, studied by laser-Doppler technique. Acta Physiol Scand 154: 387-394, 1995.
34. 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15: 551-578, 1999.
35. Tublin ME, Bude RO, Platt JF. The resistive index in renal Doppler sonography: where do we stand? AJR Am J Roentgenol 180: 885-892, 2003.
36. Veelken R, Danckwart L, Rohmeiss P, Unger T. Effects of intravenous AVP on cardiac output, mesenteric hemodynamics, and splanchnic nerve activity. Am J Physiol Heart Circ Physiol 257: H658-H664, 1989.
37. Veelken R, Hilgers KF, Porst M, Krause H, Hartner A, Schmieder RE. Effects of sympathetic nerves and angiotensin II on renal sodium and water handling in rats with common bile duct ligature. Am J Physiol Renal Physiol 288: F1267-F1275, 2005.
38. Veelken R, Schelling P, Unger T. An approach to measuring cardiac output with Doppler flow probes in conscious rats. Am J Physiol Heart Circ Physiol 255: H1206-H1210, 1988.
39. Victor RG, Thoren P, Morgan DA, Mark AL. Differential control of adrenal and renal sympathetic nerve activity during hemorrhagic hypotension in rats. Circ Res 64: 686-694, 1989.
40. Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 90: 4304-4308, 1993.
41. Waynforth HB, Flecknell PA. Assessment of depth of anaesthesia. In: Experimental and Surgical Technique in the Rat (2nd Ed.). London: Academic, 1992, p. 125-126.
42. Wiesener MS, Jurgensen JS, Rosenberger C, Scholze CK, Horstrup JH, Warnecke C, Mandriota S, Bechmann I, Frei UA, Pugh CW, Ratcliffe PJ, Bachmann S, Maxwell PH, Eckardt KU. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J 17: 271-273, 2003.
43. Woodcock EA, Morris MJ, McLeod JK, Johnston CI. Specific increase in renal alpha 1-adrenergic receptors following unilateral renal denervation. J Recept Res 5: 133-146, 1985.