Syntheses of immunomodulating androstanes and stigmastanes: Comparison of their TNF-α inhibitory activity

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 24, 2007, Pages 7538-7544

  Ramírez, Javier A ^a   Bruttomesso, Andrea C ^a   Michelini, Flavia M ^a   Acebedo, Sofía L ^a   Alché, Laura E ^a   Galagovsky, Lydia R ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Androstane; DHEA; Immune regulation; Steroids; Stigmastane; Tumor necrosis factor

Indexed keywords

3BETA BROMO 5 HYDROXY 5ALPHA ANDROSTANE 6,17 DIONE; 3BETA BROMO 5 HYDROXY DEXTRO HOMO 17ALPHA OXA 5ALPHA ANDROSTANE 6,17 DIONE; 3BETA BROMO 5ALPHA,6ALPHA EPOXY DEXTRO HOMO 17ALPHA OXAANDROSTAN 17 ONE; 3BETA BROMO 5ALPHA,6ALPHA EPOXYANDROSTAN 17 ONE; 3BETA BROMOSTIGMAST 5 ENE 22,23 DIOL; 3BETA CHLOROSTIGMAST 5 ENE 22,23 DIOL; 3BETA FLUORO 5 HYDROXY 5ALPHA STIGMAST 22 EN 6 ONE; 3BETA FLUORO 5,22,23 TRIHYDROXY 5ALPHA STIGMASTAN 6 ONE; 3BETA FLUOROSTIGMAST 5 ENE 22,23 DIOL; 3BETA,5 DIHYDROXY 5ALPHA ANDROSTANE 6,17 DIONE; ANDROSTANE DERIVATIVE; PRASTERONE; STEROID; STIGMAST 5 ENE 3BETA,22,23 TRIOL; STIGMASTEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; IN VITRO STUDY; MACROPHAGE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANDROSTANES; ANIMALS; CELL LINE; CHOLESTANES; DEHYDROEPIANDROSTERONE; DRUG EVALUATION, PRECLINICAL; IMMUNOLOGIC FACTORS; MICE; MOLECULAR STRUCTURE; STIGMASTEROL; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 35348895160     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.09.012     Document Type: Article

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