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Volumn 14, Issue 3, 2007, Pages 270-279

Effect of caffeic acid phenethyl ester on the regression of endometrial explants in an experimental rat model

Author keywords

Caffeic acid phenethyl ester; Cyclooxygenase type 2 inhibitors; Endometriosis; Oxidative stress

Indexed keywords

CAFFEIC ACID PHENETHYL ESTER; CYCLOOXYGENASE 2; SUPEROXIDE DISMUTASE; ANTIOXIDANT; CAFFEIC ACID DERIVATIVE; CATALASE; DRUG DERIVATIVE; MALONALDEHYDE; NONSTEROID ANTIINFLAMMATORY AGENT; PHENETHYL ALCOHOL;

EID: 35348888557     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719107300911     Document Type: Article
Times cited : (20)

References (46)
  • 1
    • 33749127435 scopus 로고    scopus 로고
    • Female infertility and free radicals: Potential role in adhesions and endometriosis
    • Alpay Z., Saed GM, Diamond MP Female infertility and free radicals: potential role in adhesions and endometriosis. J Soc Gynecol Investig. 2006 ; 13: 390-398.
    • (2006) J Soc Gynecol Investig , vol.13 , pp. 390-398
    • Alpay, Z.1    Saed, G.M.2    Diamond, M.P.3
  • 2
    • 0000929470 scopus 로고
    • Peritoneal endometriosis is due to the menstrual dissemination of endometrial tissue into the peritoneal cavity
    • Sampson J. Peritoneal endometriosis is due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 1927 ; 4: 433-469.
    • (1927) Am J Obstet Gynecol. , vol.4 , pp. 433-469
    • Sampson, J.1
  • 3
    • 33748616572 scopus 로고    scopus 로고
    • Loret de Mola JR. Impact of ovarian endometrioma on assisted reproduction outcomes
    • Gupta S., Agarwal A., Agarwal R., Loret de Mola JR. Impact of ovarian endometrioma on assisted reproduction outcomes. Reprod Biomed Online. 2006 ; 13: 349-360.
    • (2006) Reprod Biomed Online , vol.13 , pp. 349-360
    • Gupta, S.1    Agarwal, A.2    Agarwal, R.3
  • 4
    • 0036787873 scopus 로고    scopus 로고
    • Iron overload in the peritoneal cavity of women with pelvic endometriosis
    • Van Langendonckt A., Casanas-Roux F., Donnez J. Iron overload in the peritoneal cavity of women with pelvic endometriosis. Fertil Steril. 2002 ; 78: 712-718.
    • (2002) Fertil Steril , vol.78 , pp. 712-718
    • Van Langendonckt, A.1    Casanas-Roux, F.2    Donnez, J.3
  • 5
    • 0033168621 scopus 로고    scopus 로고
    • Immunohistochemical assessment of superoxide dismutase expression in the endometrium in endometriosis and adenomyosis
    • Ota H., Igarashi S., Hatazawa J., Tanaka T. Immunohistochemical assessment of superoxide dismutase expression in the endometrium in endometriosis and adenomyosis. Fertil Steril. 1999 ; 72: 129-134.
    • (1999) Fertil Steril. , vol.72 , pp. 129-134
    • Ota, H.1    Igarashi, S.2    Hatazawa, J.3    Tanaka, T.4
  • 6
    • 0034254570 scopus 로고    scopus 로고
    • Aberrant expression of glutathione peroxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis
    • Ota H., Igarashi S., Kato N., Tanaka T. Aberrant expression of glutathione peroxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis. Fertil Steril. 2000 ; 74: 313-318.
    • (2000) Fertil Steril. , vol.74 , pp. 313-318
    • Ota, H.1    Igarashi, S.2    Kato, N.3    Tanaka, T.4
  • 7
    • 0035056445 scopus 로고    scopus 로고
    • Xanthine oxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis
    • Ota H., Igarashi S., Tanaka T. Xanthine oxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis. Fertil Steril. 2001 ; 75: 785-790.
    • (2001) Fertil Steril. , vol.75 , pp. 785-790
    • Ota, H.1    Igarashi, S.2    Tanaka, T.3
  • 8
    • 0032854615 scopus 로고    scopus 로고
    • The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischemia/reperfusion injury in rabbits
    • Ilhan A., Koltuksuz U., Ozen S., Uz E., Ciralik H., Akyol O. The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischemia/reperfusion injury in rabbits. Eur J Cardiothorac Surg. 1999 ; 16: 458-463.
    • (1999) Eur J Cardiothorac Surg. , vol.16 , pp. 458-463
    • Ilhan, A.1    Koltuksuz, U.2    Ozen, S.3    Uz, E.4    Ciralik, H.5    Akyol, O.6
  • 9
    • 0027732287 scopus 로고
    • Mechanisms involved in the antiinflammatory effect of propolis extract
    • Khayyal MT, el-Ghazaly MA, el-Khatip AS Mechanisms involved in the antiinflammatory effect of propolis extract. Drugs Exp Clin Res. 1993 ; 19: 197-203.
    • (1993) Drugs Exp Clin Res. , vol.19 , pp. 197-203
    • Khayyal, M.T.1    Ma, E.2    El-Khatip, A.S.3
  • 10
    • 0033562995 scopus 로고    scopus 로고
    • Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation
    • Michaluart P., Masferrer JL, Carothers AM, et al. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res. 1999 ; 59: 2347-2352.
    • (1999) Cancer Res. , vol.59 , pp. 2347-2352
    • Michaluart, P.1    Masferrer, J.L.2    Carothers, A.M.3
  • 12
    • 0028983181 scopus 로고
    • Structure-activity relationship of caffeic acid analogues on xanthine oxidase inhibition
    • Chan WS, Wen PC, Chiang HC Structure-activity relationship of caffeic acid analogues on xanthine oxidase inhibition. Anticancer Res. 1995 ; 15: 703-707.
    • (1995) Anticancer Res. , vol.15 , pp. 703-707
    • Chan, W.S.1    Wen, P.C.2    Chiang, H.C.3
  • 13
    • 0027302627 scopus 로고
    • In vitro and in vivo reversible and irreversible inhibition of rat glutathione S-transferase isoenzymes by caffeic acid and its 2-S-glutathionyl conjugate
    • Schefferlie JG, van Bladeren PJ. In vitro and in vivo reversible and irreversible inhibition of rat glutathione S-transferase isoenzymes by caffeic acid and its 2-S-glutathionyl conjugate. Food Chem Toxicol. 1993 ; 31: 475-482.
    • (1993) Food Chem Toxicol. , vol.31 , pp. 475-482
    • Schefferlie, J.G.1    Van Bladeren, P.J.2
  • 14
    • 0035097459 scopus 로고    scopus 로고
    • The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells
    • Chen YJ, Shiao MS, Wang SY The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells. Anticancer Drugs. 2001 ; 12: 143-149.
    • (2001) Anticancer Drugs , vol.12 , pp. 143-149
    • Chen, Y.J.1    Shiao, M.S.2    Wang, S.Y.3
  • 15
    • 0028070994 scopus 로고
    • Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds
    • Fesen MR, Pommier Y., Leteurtre E., Hiroguchi S., Yung J., Kohn KW Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol. 1994 ; 48: 595-608.
    • (1994) Biochem Pharmacol. , vol.48 , pp. 595-608
    • Fesen, M.R.1    Pommier, Y.2    Leteurtre, E.3    Hiroguchi, S.4    Yung, J.5    Kohn, K.W.6
  • 16
    • 0033250855 scopus 로고    scopus 로고
    • Suppressive effects of propolis in rat adjuvant arthritis
    • Park EH, Kahng JH Suppressive effects of propolis in rat adjuvant arthritis. Arch Pharm Res. 1999 ; 22: 554-558.
    • (1999) Arch Pharm Res. , vol.22 , pp. 554-558
    • Park, E.H.1    Kahng, J.H.2
  • 17
    • 0022397515 scopus 로고
    • Studies on the surgical induction of endometriosis in the rat
    • Vernon MW, Wilson EA Studies on the surgical induction of endometriosis in the rat. Fertil Steril. 1985 ; 44: 684-694.
    • (1985) Fertil Steril. , vol.44 , pp. 684-694
    • Vernon, M.W.1    Wilson, E.A.2
  • 18
    • 33745242316 scopus 로고    scopus 로고
    • Leflunomide- an immunomodulator-induces regression of endometrial explants in a rat model of endometriosis
    • Uygur D., Aytan H., Zergeroglu S., Batioglu S. Leflunomide- an immunomodulator-induces regression of endometrial explants in a rat model of endometriosis. J Soc Gynecol Investig. 2006 ; 13: 378-383.
    • (2006) J Soc Gynecol Investig , vol.13 , pp. 378-383
    • Uygur, D.1    Aytan, H.2    Zergeroglu, S.3    Batioglu, S.4
  • 19
    • 24144434493 scopus 로고    scopus 로고
    • Comparative analysis of the protective effects of melatonin and caffeic acid phenethyl ester (CAPE) on mobile phone-induced renal impairment in rat
    • Ozguner F., Oktem F., Armagan A., et al. Comparative analysis of the protective effects of melatonin and caffeic acid phenethyl ester (CAPE) on mobile phone-induced renal impairment in rat. Mol Cell Biochem. 2005 ; 276: 31-37.
    • (2005) Mol Cell Biochem. , vol.276 , pp. 31-37
    • Ozguner, F.1    Oktem, F.2    Armagan, A.3
  • 20
    • 0033562995 scopus 로고    scopus 로고
    • Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation
    • Michaluart P., Masferrer JL, Carothers AM, et al. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res. 1999 ; 59: 2347-2352.
    • (1999) Cancer Res. , vol.59 , pp. 2347-2352
    • Michaluart, P.1    Masferrer, J.L.2    Carothers, A.M.3
  • 21
    • 0023952554 scopus 로고    scopus 로고
    • A simple method for clinical assay of superoxide dismutase
    • SunY., Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1998 ; 34 ; 497-500.
    • (1998) Clin Chem , vol.34 , pp. 497-500
    • Suny1    Oberley, L.W.2    Li, Y.3
  • 22
    • 0027518384 scopus 로고
    • A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction
    • Durak I., Yurtarslani Z., Canbolat O., Akyol O. A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clin Chim Acta. 1993 ; 214: 103-104.
    • (1993) Clin Chim Acta , vol.214 , pp. 103-104
    • Durak, I.1    Yurtarslani, Z.2    Canbolat, O.3    Akyol, O.4
  • 23
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi Y. Catalase in vitro. Methods Enzymol. 1984 ; 105: 121-126.
    • (1984) Methods Enzymol. , vol.105 , pp. 121-126
    • Aebi, Y.1
  • 24
    • 0033168742 scopus 로고    scopus 로고
    • Regression of endometrial explants in a rat model of endometriosis treated with the immune modulators loxoribine and levamisole
    • Keenan JA, Williams-Boyce PK, Massey PJ, Chen TT, Caudleb MR, Bukovsky A. Regression of endometrial explants in a rat model of endometriosis treated with the immune modulators loxoribine and levamisole. Fertil Steril. 1999 ; 72: 135-134.
    • (1999) Fertil Steril. , vol.72 , pp. 135-134
    • Keenan, J.A.1    Williams-Boyce, P.K.2    Massey, P.J.3    Chen, T.T.4    Caudleb, M.R.5    Bukovsky, A.6
  • 25
    • 0035107695 scopus 로고    scopus 로고
    • Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis
    • Ota H., Igarashi S., Sasaki M., Tanaka T. Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis. Hum Reprod. 2001 ; 16: 561-566.
    • (2001) Hum Reprod , vol.16 , pp. 561-566
    • Ota, H.1    Igarashi, S.2    Sasaki, M.3    Tanaka, T.4
  • 26
    • 0036218101 scopus 로고    scopus 로고
    • Using rats as a research model for the study of endometriosis
    • Sharpe-Timms KL Using rats as a research model for the study of endometriosis. Ann N Y Acad Sci. 2002 ; 955: 318-327.
    • (2002) Ann N Y Acad Sci. , vol.955 , pp. 318-327
    • Sharpe-Timms, K.L.1
  • 27
    • 0036790827 scopus 로고    scopus 로고
    • Pathological evaluation of the rat endometriosis model
    • Uchiide I., Ihara T., Sugamata M. Pathological evaluation of the rat endometriosis model. Fertil Steril. 2002 ; 78: 782-786.
    • (2002) Fertil Steril. , vol.78 , pp. 782-786
    • Uchiide, I.1    Ihara, T.2    Sugamata, M.3
  • 28
    • 0023192407 scopus 로고
    • Enhancement of human monocyte and peritoneal macrophage chemiluminescence activities in women with endometriosis. Am J Reprod Immun
    • Zeller JM, Henig I., Radwanska E., Dmowski WP Enhancement of human monocyte and peritoneal macrophage chemiluminescence activities in women with endometriosis. Am J Reprod Immun Microbiol. 1987 ; 3: 78-82.
    • (1987) Microbiol. , vol.3 , pp. 78-82
    • Zeller, J.M.1    Henig, I.2    Radwanska, E.3    Dmowski, W.P.4
  • 29
    • 0036175928 scopus 로고    scopus 로고
    • Prediction of endometriosis with serum and peritoneal fluid markers: A prospective controlled trial
    • Bedaiwy MA, Falcone T., Sharnii RK, Goldberg JM, Attaran M., Nelson DR Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial. Hum Reprod. 2002 ; 17: 426-431.
    • (2002) Hum Reprod , vol.17 , pp. 426-431
    • Ma, B.1    Falcone, T.2    Sharnii, R.K.3    Goldberg, J.M.4    Attaran, M.5    Nelson, D.R.6
  • 30
    • 0343051747 scopus 로고    scopus 로고
    • Importance of reactive oxygen species in the peritoneal fluid of women with endometriosis or idiopathic infertility
    • Wang Y., Sharma RK, Falcone T., Goldberg J., Agarwal A. Importance of reactive oxygen species in the peritoneal fluid of women with endometriosis or idiopathic infertility. Fertil Steril. 1997 ; 68: 826-830.
    • (1997) Fertil Steril. , vol.68 , pp. 826-830
    • Wang, Y.1    Sharma, R.K.2    Falcone, T.3    Goldberg, J.4    Agarwal, A.5
  • 31
    • 0033090453 scopus 로고    scopus 로고
    • Malonyldialdehyde and total antioxidant status in the peritoneal fluid of infertile women [in Polish]
    • Polak G., Rola R., Gogacz M., Koziol-Montewka M., Kotarski J. Malonyldialdehyde and total antioxidant status in the peritoneal fluid of infertile women [in Polish]. Ginekol Pol. 1999 ; 70: 135-140.
    • (1999) Ginekol Pol. , vol.70 , pp. 135-140
    • Polak, G.1    Rola, R.2    Gogacz, M.3    Koziol-Montewka, M.4    Kotarski, J.5
  • 32
    • 0033151670 scopus 로고    scopus 로고
    • Autoantibodies to markers of oxidative stress are elevated in women with endometriosis
    • Shanti A., Santanam N., Morales AJ, Parthasarathy S., Murphy AA Autoantibodies to markers of oxidative stress are elevated in women with endometriosis. Fertil Steril. 1999 ; 71: 1115-1118.
    • (1999) Fertil Steril. , vol.71 , pp. 1115-1118
    • Shanti, A.1    Santanam, N.2    Morales, A.J.3    Parthasarathy, S.4    Murphy, A.A.5
  • 33
    • 33745966683 scopus 로고    scopus 로고
    • Antioxidant supplementation reduces total chemokines and inflammatory cytokines in women with endometriosis
    • Santanam NK, Kavlaradze N., Dominguez C. Antioxidant supplementation reduces total chemokines and inflammatory cytokines in women with endometriosis. Fertil Steril. 2003 ; 8: 32-33.
    • (2003) Fertil Steril. , vol.8 , pp. 32-33
    • Santanam, N.K.1    Kavlaradze, N.2    Dominguez, C.3
  • 34
    • 0026085362 scopus 로고
    • Immunomodulation with pentoxifylline abrogates macrophage-mediated infertility in an in vivo model: A paradigm for a novel approach to the treatment of endometriosis-associated subfertility
    • Steinleitner A., Lambert H., Roy S. Immunomodulation with pentoxifylline abrogates macrophage-mediated infertility in an in vivo model: a paradigm for a novel approach to the treatment of endometriosis-associated subfertility. Fertil Steril. 1991 ; 55: 26-31.
    • (1991) Fertil Steril. , vol.55 , pp. 26-31
    • Steinleitner, A.1    Lambert, H.2    Roy, S.3
  • 35
    • 0025828612 scopus 로고
    • Periovulatory calcium channel blockade enhances reproductive performance in an animal model for endometriosis-associated subfertility
    • Steinleitner A., Lambert H., Suarez M., Serpa N., Robin B., Cantor B. Periovulatory calcium channel blockade enhances reproductive performance in an animal model for endometriosis-associated subfertility. Am J Obstet Gynecol. 1991 ; 164: 949-952.
    • (1991) Am J Obstet Gynecol. , vol.164 , pp. 949-952
    • Steinleitner, A.1    Lambert, H.2    Suarez, M.3    Serpa, N.4    Robin, B.5    Cantor, B.6
  • 36
    • 0142205817 scopus 로고    scopus 로고
    • Progesterone antagonists and progesterone receptor modulators: An overview
    • Spitz IM Progesterone antagonists and progesterone receptor modulators: an overview. Steroids. 2003 ; 68: 981-993.
    • (2003) Steroids , vol.68 , pp. 981-993
    • Spitz, I.M.1
  • 37
    • 0026092319 scopus 로고
    • Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model
    • Portz DM, Elkins TE, While R., Warren J., Adadevoh S., Randolph J. Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model. Int J Fertil. 1991 ; 16: 39-42.
    • (1991) Int J Fertil , vol.16 , pp. 39-42
    • Portz, D.M.1    Elkins, T.E.2    While, R.3    Warren, J.4    Adadevoh, S.5    Randolph, J.6
  • 40
    • 0343742650 scopus 로고    scopus 로고
    • Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells
    • Arici A., Oral E., Attar E., Tazuke SI, Olive DL Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells. Fertil Steril. 1997 ; 67: 1065-1072.
    • (1997) Fertil Steril. , vol.67 , pp. 1065-1072
    • Arici, A.1    Oral, E.2    Attar, E.3    Tazuke, S.I.4    Olive, D.L.5
  • 41
    • 1542723183 scopus 로고    scopus 로고
    • Efficacy of anti-tumor necrosis factor therapy in the treatment of spontaneous endometriosis in baboons
    • Barrier BF, Bates GW, Leland MM, Leach DA, Robinson RD, Propst AM Efficacy of anti-tumor necrosis factor therapy in the treatment of spontaneous endometriosis in baboons. Fertil Steril. 2004 ; 81 (suppl 1). 775-779.
    • (2004) Fertil Steril. , vol.81 , Issue.1 , pp. 775-779
    • Barrier, B.F.1    Bates, G.W.2    Leland, M.M.3    Leach, D.A.4    Robinson, R.D.5    Propst, A.M.6
  • 42
    • 29244443958 scopus 로고    scopus 로고
    • Caffeic acid phenethyl ester decreases acute pneumonitis after irradiation in vitro and in vivo. BMC
    • Chen MF, Keng PC, Lin PY, Yang CT, Liao SK, Chen WC Caffeic acid phenethyl ester decreases acute pneumonitis after irradiation in vitro and in vivo. BMC Cancer. 2005 ; 5: 158-165.
    • (2005) Cancer , vol.5 , pp. 158-165
    • Chen, M.F.1    Keng, P.C.2    Lin, P.Y.3    Yang, C.T.4    Liao, S.K.5    Chen, W.C.6
  • 43
    • 0023039191 scopus 로고
    • Classification of endometriotic implants by morphologic appearance and capacity to synthesize prostaglandin F
    • Vermon MN, Beard JS, Graves K., Wilson EA Classification of endometriotic implants by morphologic appearance and capacity to synthesize prostaglandin F. Fertil Steril. 1986 ; 46: 801-806.
    • (1986) Fertil Steril. , vol.46 , pp. 801-806
    • Vermon, M.N.1    Beard, J.S.2    Graves, K.3    Wilson, E.A.4
  • 44
    • 10744222415 scopus 로고    scopus 로고
    • Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinicopathological parameters
    • Fagotti A., Ferrandina G., Fanfani F., Legge F., Lauriola L., Gessi M. Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinicopathological parameters. Hum Reprod. 2004 ; 19: 393-397.
    • (2004) Hum Reprod. , vol.19 , pp. 393-397
    • Fagotti, A.1    Ferrandina, G.2    Fanfani, F.3    Legge, F.4    Lauriola, L.5    Gessi, M.6
  • 45
    • 26444450506 scopus 로고    scopus 로고
    • Aromatase inhibitors and cyclooxygenase-2 (COX-2) inhibitors in endometriosis: New questions-old answers?
    • Ebert AD, Bartley J., David M. Aromatase inhibitors and cyclooxygenase-2 (COX-2) inhibitors in endometriosis: new questions-old answers? Eur J Obstet Gynecol Reprod Biol. 2005 ; 122: 144-150.
    • (2005) Eur J Obstet Gynecol Reprod Biol. , vol.122 , pp. 144-150
    • Ebert, A.D.1    Bartley, J.2    David, M.3
  • 46
    • 0033815518 scopus 로고    scopus 로고
    • Molecular basis for treating endometriosis with aromatase inhibitors
    • Bulun SE, Zeitoun KM, Takayama K., Sasano H. Molecular basis for treating endometriosis with aromatase inhibitors. Hum Reprod Update. 2000 ; 6: 413-418.
    • (2000) Hum Reprod Update. , vol.6 , pp. 413-418
    • Bulun, S.E.1    Zeitoun, K.M.2    Takayama, K.3    Sasano, H.4


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