Filaggrin gene mutations mediate severity of alopecia areata when associated with atopic dermatitis

Journal of Investigative Dermatology

Volumn 127, Issue 11, 2007, Pages 2494-

  Blyumin, Marianna L ^a   Hu, Shasa ^a   Kirsner, Robert S ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FILAGGRIN;

ALLERGIC RHINITIS; ALOPECIA AREATA; ASTHMA; ATOPIC DERMATITIS; DISEASE SEVERITY; FILAGGRIN GENE; GENE; GENE FUNCTION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC LINKAGE; HUMAN; NOTE; PRIORITY JOURNAL; RISK FACTOR;

EID: 35348877295     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5701137     Document Type: Note

References (4)

1. Betz RC, Pforr J, Flaquer A, Redler S, Hanneken S, Eigelshoven S et al. (2007) Loss-of-function mutations in the Filaggrin gene and alopecia areata: strong risk factor for a severe course of disease in patients comorbid for atopic disease. J Invest Dermatol 127:2539-43.
2. Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP et al. (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 38:441-6
3. Smith FJ, Irvine AD, Terron-Kwiatkowski A, Sandilands A, Campbell LE, Zhao Y et al. (2006) Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet 38:337-42
4. Stemmler S, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S (2007) Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis. J Invest Dermatol 127:722-4