Pathophysiology of nocturnal scratching in childhood atopic dermatitis: The role of brain-derived neurotrophic factor and substance P

British Journal of Dermatology

Volumn 157, Issue 5, 2007, Pages 922-925

  Hon, K L E ^a   Lam, M C A ^a   Wong, K Y ^a   Leung, T F ^a   Ng, P C ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Atopic dermatitis; BDNF; Chemokine; Quality of life; SCORAD; Substance P

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHEMOKINE; CUTANEOUS T CELL ATTRACTING CYTOKINE; CYTOKINE; IMMUNOGLOBULIN E; SUBSTANCE P; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; ATOPIC DERMATITIS; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; EOSINOPHIL COUNT; FEMALE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MALE; MONITOR; MOTION; NIGHT SLEEP; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PRURITUS; QUALITY OF LIFE; SCHOOL CHILD; SCORING SYSTEM; SCRATCHING; T LYMPHOCYTE;

BRAIN-DERIVED NEUROTROPHIC FACTOR; CHEMOKINES; CHILD; DERMATITIS, ATOPIC; EOSINOPHILS; FEMALE; HUMANS; IMMUNOGLOBULIN E; MALE; PRURITUS; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; SLEEP; SUBSTANCE P;

EID: 35348850974     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2007.08149.x     Document Type: Article

References (23)

1. Rees JL, Laidlaw A. Pruritus: more scratch than itch. Clin Exp Dermatol 1999 24 : 490 3.
2. Steinhoff M, Stander S, Seeliger S et al. Modern aspects of cutaneous neurogenic inflammation. Arch Dermatol 2003 139 : 1479 88.
3. Raap U, Goltz C, Deneka N et al. Brain-derived neurotrophic factor is increased in atopic dermatitis and modulates eosinophil functions compared with that seen in nonatopic subjects. J Allergy Clin Immunol 2005 115 : 1268 75.
4. Raap U, Werfel T, Goltz C et al. Circulating levels of brain-derived neurotrophic factor correlate with disease severity in the intrinsic type of atopic dermatitis. Allergy 2006 61 : 1416 18.
5. Noga O, Englmann C, Hanf G et al. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Clin Exp Allergy 2003 33 : 649 54.
6. Toyoda M, Nakamura M, Makino T et al. Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis. Br J Dermatol 2002 147 : 71 9.
7. Hon KL, Ma KC, Wong E et al. Validation of a self-administered questionnaire in Chinese in the assessment of eczema severity. Pediatr Dermatol 2003 20 : 465 9.
8. Hon KL, Leung TF, Wong Y et al. Lesson from performing SCORADs in children with atopic dermatitis: subjective symptoms do not correlate well with disease extent or intensity. Int J Dermatol 2006 45 : 728 30.
9. Hon KL, Lam MC, Leung TF et al. Nocturnal wrist movements are correlated with objective clinical scores and plasma chemokine levels in children with atopic dermatitis. Br J Dermatol 2006 154 : 629 35.
10. Leung TF, Ma KC, Hon KL et al. Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children. Pediatr Allergy Immunol 2003 14 : 296 301.
11. Hon KL, Leung TF, Ma KC et al. Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children. Clin Exp Dermatol 2004 29 : 293 6.
12. Hon KL, Leung TF, Ma KC et al. Urinary leukotriene E4 correlates with severity of atopic dermatitis in children. Clin Exp Dermatol 2004 29 : 277 81.
13. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980 2 : 44 7.
14. Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1993 186 : 23 31.
15. Kunz B, Oranje AP, Labreze L et al. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology 1997 195 : 10 19.
16. Hon KL, Lam MC, Kam WY et al. Non-invasive home-based assessment of itch in children with atopic dermatitis: PA-21. Br J Dermatol 2005 153 (Suppl. 1 89.
17. Andoh T, Katsube N, Maruyama M et al. Involvement of leukotriene B(4) in substance P-induced itch-associated response in mice. J Invest Dermatol 2001 117 : 1621 6.
18. Sonkoly E, Muller A, Lauerma AI et al. IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol 2006 117 : 411 17.
19. Bilsborough J, Leung DY, Maurer M et al. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. J Allergy Clin Immunol 2006 117 : 418 25.
20. Klein PA, Clark RA. An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Arch Dermatol 1999 135 : 1522 5.
21. Hon KL, Leung TF, Ma KC et al. Serum concentration of IL-18 correlates with disease extent in young children with atopic dermatitis. Pediatr Dermatol 2004 21 : 619 22.
22. Hon KL, Lam MC, Leung TF et al. A malignant itch. J Natl Med Assoc 2006 98 : 1192 4.
23. Hon KL, Lam MC, Leung TF et al. Assessing itch in children with atopic dermatitis treated with tacrolimus: objective versus subjective assessment. Adv Ther 2007 24 : 23 8.