Milrinone does not improve free flap survival in microvascular surgery

Anaesthesia and Intensive Care

Volumn 35, Issue 5, 2007, Pages 720-725

  Jones, S J ^a,b   Scott, D A ^a,b   Watson, R ^a,b   Morrison, W A ^a,c  

^a ST VINCENT S HOSPITAL   (Australia)

^b Department of Anaesthesia ^*  (Australia)

^c Bernard O'Brien Institute of Microsurgery   (Australia)

Author keywords

Free flaps; Microvascular surgery; Milrinone; Phosphodiesterase inhibitors; Vasospasm

Indexed keywords

METARAMINOL; MIDAZOLAM; MILRINONE; PLACEBO;

ADULT; AGED; ARTERY DILATATION; ARTERY SPASM; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; FEMALE; FREE TISSUE GRAFT; GRAFT PERFUSION; GRAFT SURVIVAL; HEART OUTPUT; HEMATOMA; HUMAN; HYPOTENSION; MALE; MICROVASCULAR SURGERY; MOBILIZATION; OUTCOME ASSESSMENT; PEROPERATIVE CARE; POSTOPERATIVE CARE; PRESSOR RESPONSE; RANDOMIZED CONTROLLED TRIAL; REOPERATION; THROMBOSIS;

EID: 35348830520     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x0703500510     Document Type: Article

References (12)

1. Jones JW. Adjunctive measures in microvascular surgery. J Reconstr Microsurg 1997; 13:585-592.
2. Banic A, Krejci V, Erni D, Wheatley AM, Sigurdsson GH. Effects of sodium nitroprusside and phenylephrine on blood flow in free musculocutaneous flaps during general anesthesia. Anesthesiology 1999; 90:147-155.
3. Johnson PC, Barker JH. Thrombosis and antithrombotic therapy in microvascular surgery. Clin Plast Surg 1992; 19:799-807.
4. Lobato EB, Janelle GM, Urdaneta F, Martin TD. Comparison of milrinone versus nitroglycerin, alone and in combination, on grafted internal mammary artery flow after cardiopulmonary bypass: effects of alpha-adrenergic stimulation. J Cardiothorac Vasc Anesth 2001; 15:723-727.
5. He GW, Yang CQ. Inhibition of vasoconstriction by phosphodiesterase III inhibitor milrinone in human conduit arteries used as coronary bypass grafts. J Cardiovasc Pharmacol 1996; 28:208-214.
6. Ichioka S, Nakatsuka T, Ohura N, Sato Y, Harii K. Clinical use of amrinone (a selective phosphodiesterase III inhibitor) in reconstructive surgery. Plast Reconstr Surg 2001; 108:1931-1937.
7. Sigurdsson GH, Thomson D. Anaesthesia and microvascular surgery: clinical practice and research. Eur J Anaesthesiol 1995; 12:101-122.
8. Daniel RK, Kerrigan CL. Skin flaps: an anatomical and hemodynamic approach. Clin Plast Surg 1979; 6:181-200.
9. Ichioka S, Nakatsuka T. Amrinone, a selective phosphodiesterase III inhibitor, improves microcirculation and flap survival: a comparative study with prostaglandin E1. J Surg Res 1998; 75:42-48.
10. Erni D, Banic A, Signer C, Sigurdsson GH. Effects of epidural anaesthesia on microcirculatory blood flow in free flaps in patients under general anaesthesia. Eur J Anaesthesiol 1999; 16:692-698.
11. Banic A, Krejci V, Erni D, Petersen-Felix S, Sigurdsson GH. Effects of extradural anesthesia on microcirculatory blood flow in free latissimus dorsi musculocutaneous flaps in pigs. Plast Reconstr Surg 1997; 100:945-955.
12. Beavis RE, Mullany CG, Cronin KD, Scott DA, Treagus BC, Zhikun T et al. An experimental in-vivo study of the canine internal mammary artery and its response to vasoactive drugs. J Thorac Cardiovasc Surg 1988; 95:1059-1066.