The clinical effect of topical phenytoin on wound healing: A systematic review

British Journal of Dermatology

Volumn 157, Issue 5, 2007, Pages 997-1004

  Shaw, J ^a   Hughes, C M ^b   Lagan, K M ^b   Bell, P M ^a,c  

^a ROYAL VICTORIA HOSPITAL   (United Kingdom)

^b UNIVERSITY OF ULSTER   (United Kingdom)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Phenytoin; Systematic review; Wounds

Indexed keywords

PHENYTOIN; SULFADIAZINE SILVER;

BURN; CHRONIC WOUND; CLINICAL TRIAL; DATA ANALYSIS; DATA BASE; DIABETIC FOOT; DRUG EFFECT; FOOT ULCER; HUMAN; LEG ULCER; LEPROSY; MEDLINE; META ANALYSIS; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; WOUND CARE; WOUND CLOSURE; WOUND HEALING;

ADMINISTRATION, TOPICAL; ANTICONVULSANTS; HUMANS; PHENYTOIN; RANDOMIZED CONTROLLED TRIALS AS TOPIC; WOUND HEALING; WOUNDS AND INJURIES;

EID: 35348829375     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2007.08160.x     Document Type: Review

References (28)

1. Merritt HH, Putnam TJ. Sodium diphenyl hydantoinate in the treatment of convulsive disorders. JAMA 1938 111 : 1068 73.
2. Talas G, Brown RA, McGrouther A. Role of phenytoin in wound healing - a wound pharmacology perspective. Biochem Pharmacol 1999 57 : 1085 94.
3. Shapiro M. Acceleration of gingival wound healing in non-epileptic patients receiving diphenylhydantoin sodium. Exp Med Surg 1958 16 : 41 53.
4. Brown RS, Beaver WT, Bottomley WK. On the mechanism of drug induced gingival hyperplasia. J Oral Pathol Med 1991 20 : 201 9.
5. Bonnaure-Mallet M, Tricot-Doleux S, Godeau GJ. Changes in extracellular matrix macromolecules in human gingiva after treatment with drugs inducing gingival overgrowth. Arch Oral Biol 1995 40 : 393 400.
6. El-Zayat SG. Preliminary experience with topical phenytoin in wound healing in a war zone. Mil Med 1989 154 : 178 80.
7. Pendse AK, Sharma A, Sodani A, Hada S. Topical phenytoin in wound healing. Int J Dermatol 1993 32 : 214 17.
8. Modaghegh S, Salehian B, Tavassoli M et al. Use of phenytoin in healing of war and non war wounds. A pilot study of 25 cases. Int J Dermatol 1989 28 : 347 50.
9. Muthukumarasamy MG, Sivakumar G, Manoharan G. Topical phenytoin in diabetic foot ulcers. Diabetes Care 1991 14 : 909 11.
10. Pai MRSM, Sitaraman N, Kotian MS. Topical phenytoin in diabetic ulcers: a double blind controlled trial. Indian J Med Sci 2001 55 : 593 9.
11. Steinstrasser I, Merkle HP. Dermal metabolism of topically applied drugs: pathways and models reconsidered. Pharm Acta Helv 1995 70 : 3 24.
12. Lodha SC, Lohiya ML, Vyas MC et al. Role of phenytoin in healing of large abscess cavities. Br J Surg 1991 78 : 105 8.
13. van Tulder MW, Assendelft WJ, Koes BW, Bouter LM. Method guidelines for systematic reviews in the Cochrane Collaboration Back Review Group for Spinal Disorders. Spine 1997 22 : 2323 30.
14. Herbert RD. How to estimate treatment effects from reports of clinical trials. I: continuous outcomes. Aust J Physiother 2000 46 : 229 35.
15. Herbert RD. How to estimate treatment effects from reports of clinical trials. II: dichotomous outcomes. Aust J Physiother 2000 46 : 309 13.
16. Simpson GM, Kunz E, Slafta J. Use of sodium diphenylhydantoin in treatment of leg ulcers. N Y State J Med 1965 65 : 886 8.
17. Oluwatosin OM, Olabanji JK, Oluwatosin OA et al. A comparison of topical honey and phenytoin in the treatment of chronic leg ulcers. Afr J Med Med Sci 2000 29 : 31 4.
18. Carneiro PMR, Nyawawa ETM. Topical phenytoin versus EUSOL in the treatment of non-malignant chronic leg ulcers. East Afr Med J 2003 80 : 124 9.
19. Bansal NK, Mukul MD. Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy. Int J Dermatol 1993 32 : 210 13.
20. Menezes J, Rajendran A, Jacob AJW, Vaz M. The use of topical phenytoin as an adjunct to immobilization in the treatment of trophic leprosy ulcers. Southeast Asian J Trop Med Public Health 1993 24 : 340 2.
21. Malhotra YK, Amin SS. Role of topical phenytoin in trophic ulcers of leprosy in India. Int J Lepr Other Mycobact Dis 1991 59 : 337 8.
22. Carneiro PM, Rwanyuma LR, Mkony CA. A comparison of topical phenytoin with Silverex in the treatment of superficial dermal burn wounds. Cent Afr J Med 2002 48 : 105 8.
23. Rhodes RS, Heyneman CA, Culbertson VL et al. Topical phenytoin treatment of stage II decubitus ulcers in the elderly. Ann Pharmacother 2001 35 : 675 80.
24. Yadav JK, Singhvi AM, Kumar N, Garg S. Topical phenytoin in the treatment of split-thickness skin autograft donor sites: a comparative study with polyurethane membrane drape and conventional dressing. Burns 1993 19 : 306 10.
25. Polit DF, Hungler BP. Nursing Research, Principles and Methods, 6th edn. Philadelphia : Lippincott Williams and Wilkins, 1995 474.
26. Corbett CF. Practical management of patients with painful diabetic neuropathy. Diabetes Educ 2005 31 : 523 4.
27. Yaari Y, Selzer ME, Pincus JH. Phenytoin: mechanisms of its anticonvulsant action. Ann Neurol 1986 20 : 171 84.
28. Foster AVM. Is there an evidence base for diabetic foot care? J Tissue Viability 2002 12 : 113 17.