Supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer (SAA-HCM) for micronization of levofloxacin hydrochloride

Journal of Supercritical Fluids

Volumn 43, Issue 3, 2008, Pages 524-534

  Cai, Mei Qiang ^a   Guan, Yi Xin ^a   Yao, Shan Jing ^a   Zhu, Zi Qiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Hydrodynamic cavitation mixer; Levofloxacin hydrochloride; Micronization; Supercritical fluid assisted atomization

Indexed keywords

AMORPHOUS MATERIALS; ATOMIZATION; CAVITATION; MASS TRANSFER; PARTICLE SIZE;

DRUG DELIVERY APPLICATIONS; HYDRODYNAMIC CAVITATION MIXER; LEVOFLOXACIN HYDROCHLORIDE; MICRONIZATION; SUPERCRITICAL FLUID ASSISTED ATOMIZATION;

SUPERCRITICAL FLUIDS;

EID: 35348824827     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2007.07.008     Document Type: Article

References (33)

1. Ganderton D. Targeted delivery of inhaled drugs: current challenges and future trends. J. Aerosol. Med. 12 (1999) 3-8
2. Hickey A. Inhalation Aerosols vol. 24 (1996), Dekker p. 10
3. Krukonis V.J. Supercritical fluid nucleation of difficult-to-comminute solids. Proceedings of the Annual AIChE Meeting. San Francisco, November (1984) 140 f
4. Xu C.Y., Sievers R.E., Karst U., Watkins B.A., Karbiwnyk C.M., Andersen W.C., Schaefer J.D., and Stoldt C.R. Supercritical carbon dioxide-assisted aerosolization for thin film deposition, fine powder generation and drug delivery. In: Anastas P.T., and Williamson T.C. (Eds). Green Chemistry: Frontiers in Benign Chemical Synthesis and Processes (1998), Oxford University Press, Oxford (Chapter 18)
5. Sievers R.E., Karst U., Milewski P.D., Sellers S.P., Miles B.A., Schaefer J.D., Stoldt C.R., and Xu C.Y. Formation of aqueous small droplet aerosols assisted by supercritical carbon dioxide. Aerosol Sci. Technol. 30 (1999) 3-15
6. R.E. Sievers, S.P. Sellers, J.F. Carpenter, Patent WO00/75281 (2000).
7. 2-assisted aerosolization. J. Pharm. Sci. 90 (2001) 785-797
8. 2. Int. J. Pharm. 148 (1997) 123-130
9. Kerc J., Srcic S., Knez Z., and Bozic P.S. Micronization of drugs using supercritical carbon dioxide. Int. J. Pharm. 182 (1999) 33-39
10. Reverchon E. Supercritical-assisted atomization to produce micro and/or nanoparticles of controlled size and distribution. Ind. Eng. Chem. Res. 41 (2002) 2405-2411
11. Reverchon E., and Porta G.D. Terbutaline microparticles suitable for aerosol delivery produced by supercritical assisted atomisation. Int. J. Pharm. 258 (2003) 1-9
12. Reverchon E., and Antonacci A. Polymer microparticles production by supercritical assisted atomization. J. Supercrit. Fluids 39 (2007) 444-452
13. Reverchon E. Micro and nano-particles produced by supercritical fluid assisted techniques: present status and perspectives. In: Bertucco A., and Vetter G. (Eds). Proceedings of the Fourth International Symposium on High Pressure Process Technology and Chemical Engineering (2002) 1
14. Reverchon E., and Porta G.D. Micronization of antibiotics by supercritical assisted atomization. J. Supercrit. Fluids 26 (2003) 243-252
15. Reverchon E., Porta G.D., and Spada A. Micronization of rifampicin by supercritical assisted atomization. In: Bertucco A. (Ed). Proceedings of Fourth International Symposium on High Pressure Process Technology and Chemical Engineering. Venice, Italy, AIDIC, Milano (Italy) (2002) 495
16. Porta G.D., Ercolino S.F., Parente L., and Reverchon E. Corticosteroid microparticles produced by supercritical-assisted atomization: process optimization, product characterization and "in vitro" performance. J. Pharm. Sci. 95 (2006) 2062-2076
17. Reverchon E., and Antonacci A. Chitosan microparticles production by supercritical fluid processing. Ind. Eng. Chem. Res. 45 (2006) 5722-5728
18. Reverchon E., Adami R., and Caputo G. Supercritical assisted atomization: performance comparison between laboratory and pilot scale. J. Supercrit. Fluids 37 (2006) 298-306
19. Reverchon E., and Spada A. Erythromycin micro-particles produced by supercritical fluid atomization. Powder Technol. 14 (2004) 1100-1108
20. Shekunov B.Y., Hanna M., and York P. Crystallization process in turbulent supercritical flows. J. Cryst. Growth 198/199 (1999) 1345-1351
21. 2. J. Supercrit. Fluids 21 (2001) 257-271
22. Shekunov B.Y., Baldyga J., and York P. Particle formation by mixing with supercritical antisolvent at high Reynolds numbers. Chem. Eng. Sci. 56 (2001) 2421-2433
23. Mawson S., Kanakia S., and Johnston K.P. Coaxial nozzle for control of particle morphology in precipitation with a compressed fluid antisolvent. J. Appl. Polym. Sci. 64 (1997) 2105-2118
24. Chattopadhyay P., and Gupta R.B. Protein nanoparticles formation by supercritical antisolvent with enhanced mass transfer. AIChE J. 48 (2002) 235-244
25. Flynn H.G., and Church C.C. Transient pulsations of small gas bubbles in water. J. Acoust. Soc. Am. 84 (1988) 985-998
26. Kozyuk O.V. Use of Hydrodynamic Cavitation for Emulsifying and Homogenizing Processes (1999), American Laboratory News
27. Ji J.B., Lu X..H., Cai M.Q., and Xu Z.C. Improvement of leaching process of geniposide with ultrasound. Ultrasonic Sonochem. 13 (2006) 455-462
28. Kanthale P.M., Gogate P.R., Wilhelm A.M., and Pandit A.B. Dynamics of cavitational bubbles and design of cavitational reactor: cluster approach. Ultrasonic Sonochem. 12 (2005) 441-452
29. Ambulgekar G.V., Samant S.D., and Pandit A.B. Oxidation of alkylarenes using aqueous potassium permanganate under cavitation: comparison of acoustic and hydrodynamic techniques. Ultrasonic Sonochem. 12 (2005) 85-90
30. 2-expanded fluids. Macromol. Mater. Eng. 290 (2005) 302-310
31. 2 on ultrasound-induced polymerizations in high-pressure fluids. AIChE J. 51 (2005) 1726-1732
32. Moholkar V.S., and Pandit A.B. Bubble behavior in hydrodynamic cavitation: effect of turbulence. AIChE J. 43 (1997) 1641-1648
33. Frick A., Möller H., and Wirbitzki E. Biopharmaceutical characterization of oral immediate release drug products-in vitro/in vivo comparison of phenoxymethylpenicillin potassium, glimepiride and levofloxacin. Eur. J. Pharm. Biopharm. 46 (1998) 305-311