-
1
-
-
0035032976
-
Insulin self-association and the relationship to pharmacokinetics and pharmacodynamics
-
DeFelippis MR, Chance RE, Frank BH: Insulin self-association and the relationship to pharmacokinetics and pharmacodynamics. Crit. Rev. Ther. Drug Carrier Sys. 18, 201-264 (2001).
-
(2001)
Crit. Rev. Ther. Drug Carrier Sys.
, vol.18
, pp. 201-264
-
-
DeFelippis, M.R.1
Chance, R.E.2
Frank, B.H.3
-
2
-
-
0042405177
-
Insulin administration
-
American Diabetes Association
-
American Diabetes Association: Insulin administration. Diabetes Care 26, S121-S124 (2003).
-
(2003)
Diabetes Care
, vol.26
-
-
-
3
-
-
16344372697
-
Recent strategies and methods for improving insulin delivery
-
Lin C, Gokhale R, Trivedi JS, Ranade V: Recent strategies and methods for improving insulin delivery. Drug Dev. Res. 63, 151-160 (2004).
-
(2004)
Drug Dev. Res.
, vol.63
, pp. 151-160
-
-
Lin, C.1
Gokhale, R.2
Trivedi, J.S.3
Ranade, V.4
-
4
-
-
33645974002
-
Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transfcrrin conjugates
-
Kavimandan NJ, Losi F., Peppas NA: Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transfcrrin conjugates. Biomaterials 27, 3846-3854 (2006).
-
(2006)
Biomaterials
, vol.27
, pp. 3846-3854
-
-
Kavimandan, N.J.1
Losi, F.2
Peppas, N.A.3
-
5
-
-
3242752774
-
Self-assembling nanocomplexes from insulin and water-soluble branched polyesters, poly(vinyl-3-(diethylamino)propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)-graftpoly(l-lactic acid): A novel carrier for transmucosal deliver)' of peptides
-
Simon M, Wittmar M, Bakowsky U, Kissel T: Self-assembling nanocomplexes from insulin and water-soluble branched polyesters, poly(vinyl-3-(diethylamino) propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)-graftpoly(l-lactic acid): a novel carrier for transmucosal deliver)' of peptides. Bioconjug. Chem. 15, 841-849(2004).
-
(2004)
Bioconjug. Chem.
, vol.15
, pp. 841-849
-
-
Simon, M.1
Wittmar, M.2
Bakowsky, U.3
Kissel, T.4
-
6
-
-
0025672865
-
Insulin agonist therapy: A challenge for the 1990s
-
Galloway JA, Chance RE: Insulin agonist therapy: a challenge for the 1990s. Clin. Ther. 12, 460-472(1990).
-
(1990)
Clin. Ther.
, vol.12
, pp. 460-472
-
-
Galloway, J.A.1
Chance, R.E.2
-
7
-
-
0024511962
-
The pharmacokinetic basis of insulin therapy in diabetes mellitus
-
Bolli GB: The pharmacokinetic basis of insulin therapy in diabetes mellitus. Diabeta Res. Clin. Pract. 6, S3-S16 (1989).
-
(1989)
Diabeta Res. Clin. Pract.
, vol.6
-
-
Bolli, G.B.1
-
8
-
-
0019151641
-
"Normal" insulin secretion: The goal of artificial insulin delivery systems
-
Eaton RO, Allen RC, Schade DS, Standefer JC: "Normal" insulin secretion: the goal of artificial insulin delivery systems. Diabetes Care 3, 270-273 (1980).
-
(1980)
Diabetes Care
, vol.3
, pp. 270-273
-
-
Eaton, R.O.1
Allen, R.C.2
Schade, D.S.3
Standefer, J.C.4
-
9
-
-
0023829632
-
Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects
-
Polonsky KS, Given BO, Van Cauter E: Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J. Clin. Invest. 81, 442-448 (1988).
-
(1988)
J. Clin. Invest.
, vol.81
, pp. 442-448
-
-
Polonsky, K.S.1
Given, B.O.2
Van Cauter, E.3
-
10
-
-
0025996911
-
Receptor binding redefined by a structural switch in a mutant human insulin
-
Hua QX, Shoelson SE, Kochoyan M, Weiss MA: Receptor binding redefined by a structural switch in a mutant human insulin. Nahm 354, 238-241 (1991).
-
(1991)
Nahm
, vol.354
, pp. 238-241
-
-
Hua, Q.X.1
Shoelson, S.E.2
Kochoyan, M.3
Weiss, M.A.4
-
11
-
-
0342657181
-
Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use
-
Kurrzhals P, Schaffer L, Sorensen A et al.: Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use. Diabetes 49, 999-1005 (2000).
-
(2000)
Diabetes
, vol.49
, pp. 999-1005
-
-
Kurrzhals, P.1
Schaffer, L.2
Sorensen, A.3
-
13
-
-
0030606309
-
Mapping the functional surface of insulin by design: Structure and function of a novel A-chain analogue
-
Hua QX, Hu SQ, Jia W et al.: Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue. J. Mol. Biol. 264, 390-403 (1996).
-
(1996)
J. Mol. Biol.
, vol.264
, pp. 390-403
-
-
Hua, Q.X.1
Hu, S.Q.2
Jia, W.3
-
14
-
-
0032549666
-
Mini-proinsulin and mini-IGF-1: Homologous protein sequences encoding non-homologous structures
-
Hua QX, Hu SQ, Jia W et al.: Mini-proinsulin and mini-IGF-1: homologous protein sequences encoding non-homologous structures. J. Mol. Biol. 277, 103-118 (1998).
-
(1998)
J. Mol. Biol.
, vol.277
, pp. 103-118
-
-
Hua, Q.X.1
Hu, S.Q.2
Jia, W.3
-
15
-
-
0036137007
-
A cavity-forming mutation in insulin induces segmental unfolding of a surrounding α-helix
-
Xu B, Hua QX, Nakagawa SH et al.: A cavity-forming mutation in insulin induces segmental unfolding of a surrounding α-helix. Protein Sci. 11, 104-116 (2002).
-
(2002)
Protein Sci.
, vol.11
, pp. 104-116
-
-
Xu, B.1
Hua, Q.X.2
Nakagawa, S.H.3
-
16
-
-
0036300570
-
Chiral mutagenesis of insulin's hidden receptor-binding surface: Structure of an allo-isoleucine(A2) analogue
-
Xu B, Hua QX, Nakagawa SH et al.: Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue. J. Mol Biol. 316, 435-441 (2002).
-
(2002)
J. Mol Biol.
, vol.316
, pp. 435-441
-
-
Xu, B.1
Hua, Q.X.2
Nakagawa, S.H.3
-
17
-
-
0037044828
-
Mechanism of insulin chain combination. Asymmetric roles of A-chain α-helices in disulfide pairing
-
Hua QX, Chu YC, Jia W et al.: Mechanism of insulin chain combination. Asymmetric roles of A-chain α-helices in disulfide pairing. J. Biol Chem. 277, 43443-43453 (2002).
-
(2002)
J. Biol Chem.
, vol.277
, pp. 43443-43453
-
-
Hua, Q.X.1
Chu, Y.C.2
Jia, W.3
-
18
-
-
0026698991
-
Altering the association properties of insulin by amino acid replacemenr
-
Brems ON, Alter LA, Beckage MJ, Chance RE, DiMarchi RD, Green LK: Altering the association properties of insulin by amino acid replacemenr. Protein Eng. 5, 527-533 (1992).
-
(1992)
Protein Eng.
, vol.5
, pp. 527-533
-
-
Brems, O.N.1
Alter, L.A.2
Beckage, M.J.3
Chance, R.E.4
DiMarchi, R.D.5
Green, L.K.6
-
19
-
-
0038461955
-
Insulin assembly damps conformational fluctuations: Raman analysis of amide I linewidths in native states and fibrils
-
Dong J, Wan Z, Popov M, Carey PR, Weiss MA: Insulin assembly damps conformational fluctuations: Raman analysis of amide I linewidths in native states and fibrils. J. Mol Biol 330, 431-442 (2003).
-
(2003)
J. Mol Biol
, vol.330
, pp. 431-442
-
-
Dong, J.1
Wan, Z.2
Popov, M.3
Carey, P.R.4
Weiss, M.A.5
-
20
-
-
0025880180
-
X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue
-
Derewenda U, Derewenda Z, Oodson EJ, Dodson GG, Bing X, Markussen J: X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue. J. Mol. Biol. 220, 425-433 (1991).
-
(1991)
J. Mol. Biol.
, vol.220
, pp. 425-433
-
-
Derewenda, U.1
Derewenda, Z.2
Oodson, E.J.3
Dodson, G.G.4
Bing, X.5
Markussen, J.6
-
21
-
-
0031009430
-
Alanine scanning mutagenesis of insulin
-
Kristensen, Kjeldsen T, Wiberg FC et al.: Alanine scanning mutagenesis of insulin. J. Biol Chem. 272, 12978-12983 (1997).
-
(1997)
J. Biol Chem.
, vol.272
, pp. 12978-12983
-
-
Kristensen1
Kjeldsen, T.2
Wiberg, F.C.3
-
22
-
-
0022879089
-
Role of the phenylalanine B25 side chain in directing insulin interaction with its receptor. Steric and conformational effects
-
Nakagawa SH, Tager HS: Role of the phenylalanine B25 side chain in directing insulin interaction with its receptor. Steric and conformational effects. J. Biol. Chem. 261, 7332-7341 (1986).
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 7332-7341
-
-
Nakagawa, S.H.1
Tager, H.S.2
-
23
-
-
0032577326
-
A structural switch in a mutant insulin exposes key residues for receptor binding
-
Ludvigsen S, Olsen HB, Kaarsholm NC: A structural switch in a mutant insulin exposes key residues for receptor binding. J. Mol. Biol 279, 1-9(1998).
-
(1998)
J. Mol. Biol
, vol.279
, pp. 1-9
-
-
Ludvigsen, S.1
Olsen, H.B.2
Kaarsholm, N.C.3
-
24
-
-
0034494052
-
Four new monomeric insulins obtained by alanine scanning the dimer-forming surface of the insulin molecule
-
Chen H, Shi M, Guo ZY et al.: Four new monomeric insulins obtained by alanine scanning the dimer-forming surface of the insulin molecule. Protein Eng. 13, 779-782 (2000).
-
(2000)
Protein Eng.
, vol.13
, pp. 779-782
-
-
Chen, H.1
Shi, M.2
Guo, Z.Y.3
-
25
-
-
0018569823
-
Chemical synthesis of des(tetrapeptide B27-30), Tyr(NH2)26-B and des(pentapeptide B26-30), Phe(NH2)25-B bovine insulins
-
Cosmatos NF, Katsoyannis PG: Chemical synthesis of des(tetrapeptide B27-30), Tyr(NH2)26-B and des(pentapeptide B26-30), Phe(NH2)25-B bovine insulins. Int. J. Protein Res. 14, 457-471 (1979).
-
(1979)
Int. J. Protein Res.
, vol.14
, pp. 457-471
-
-
Cosmatos, N.F.1
Katsoyannis, P.G.2
-
26
-
-
19944363834
-
Enhancing the activity of insulin at the receptor interface: Crystal structure and photo-cross-linking of A8 analogues
-
Wan Z, Xu B, Huang K et al.: Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues. Biochemistry 43, 16119-16133 (2004).
-
(2004)
Biochemistry
, vol.43
, pp. 16119-16133
-
-
Wan, Z.1
Xu, B.2
Huang, K.3
-
29
-
-
0032969538
-
Insulin analogs with improved pharmacokinetic profiles
-
Brange J, Volund A: Insulin analogs with improved pharmacokinetic profiles. Adv. Drug Del. Rev. 35, 307-335 (1999).
-
(1999)
Adv. Drug Del. Rev.
, vol.35
, pp. 307-335
-
-
Brange, J.1
Volund, A.2
-
30
-
-
0141645381
-
LysB3, GluB29 insulin: A novel insulin analog with enhanced β-cell protective action
-
Rakatzi GS, Eckel J: LysB3, GluB29 insulin: a novel insulin analog with enhanced β-cell protective action. Biochem. Biophys. Res. Comm. 310, 852-859 (2003).
-
(2003)
Biochem. Biophys. Res. Comm.
, vol.310
, pp. 852-859
-
-
Rakatzi, G.S.1
Eckel, J.2
-
31
-
-
0027972684
-
Lys(B28),Pro(B29)-human insulin: A rapidly absorbed analogue of human insulin
-
Howey DC, Bowsher RR, Brunelle RL, Woodworth JR: Lys(B28),Pro(B29)-human insulin: a rapidly absorbed analogue of human insulin. Diabetes 43, 396-402 (1994).
-
(1994)
Diabetes
, vol.43
, pp. 396-402
-
-
Howey, D.C.1
Bowsher, R.R.2
Brunelle, R.L.3
Woodworth, J.R.4
-
33
-
-
0002231742
-
New insulin preparations with prolonged action profiles-A21-modified arginine insulins
-
Seipke G, Geisen K, Neubauer HP, Pittius C, Rosskamp R, Schwabe D: New insulin preparations with prolonged action profiles-A21-modified arginine insulins. Diabetologia 35, A4 (1992).
-
(1992)
Diabetologia
, vol.35
-
-
Seipke, G.1
Geisen, K.2
Neubauer, H.P.3
Pittius, C.4
Rosskamp, R.5
Schwabe, D.6
-
34
-
-
4344701890
-
The mechanism of protraction of insulin detemir, a long-acting, acylaced analog of human insulin
-
Havelund S, Plum A, Ribel M et al.: The mechanism of protraction of insulin detemir, a long-acting, acylaced analog of human insulin. Pharm. Res. 21, 1498-1504 (2004).
-
(2004)
Pharm. Res.
, vol.21
, pp. 1498-1504
-
-
Havelund, S.1
Plum, A.2
Ribel, M.3
-
35
-
-
2442662934
-
Crystallographic and solution studies of N-lithocholyl insulin: A new generation of prolonged-acting human insulins
-
Whittingham L, Jonassen I, Havelund S et al.: Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting human insulins. Biochemistry 43, 5987-5995 (2004).
-
(2004)
Biochemistry
, vol.43
, pp. 5987-5995
-
-
Whittingham, L.1
Jonassen, I.2
Havelund, S.3
-
36
-
-
0242675981
-
Crystal structure of allo-IleA2-insulin, an inactive chiral analogue: Implications for the mechanism of receptor binding
-
Wan Z, Xu B, Chu YC, Katsoyannis PG, Weiss MA: Crystal structure of allo-IleA2-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding. Biochemistry 42, 12770-12783 (2003).
-
(2003)
Biochemistry
, vol.42
, pp. 12770-12783
-
-
Wan, Z.1
Xu, B.2
Chu, Y.C.3
Katsoyannis, P.G.4
Weiss, M.A.5
-
37
-
-
0026343488
-
Conformational flexibility of aqueous monomeric and dimenc insulin - A molecular-dynamics study
-
Mark E, HJ Berendsen C, van Gunsteren WF: Conformational flexibility of aqueous monomeric and dimenc insulin - a molecular-dynamics study. Biochemistry 30, 10866-10872 (1991).
-
(1991)
Biochemistry
, vol.30
, pp. 10866-10872
-
-
Mark, E.H.J.1
Berendsen, C.2
Van Gunsteren, W.F.3
-
39
-
-
4444383210
-
A comparison of the dynamic behavior of monomeric and dimeric insulin shows structural rearrangements in the active monomer
-
Zoete V, Meuwly M, Karplus M: A comparison of the dynamic behavior of monomeric and dimeric insulin shows structural rearrangements in the active monomer. J. Mol. Biol. 342, 913-929 (2004).
-
(2004)
J. Mol. Biol.
, vol.342
, pp. 913-929
-
-
Zoete, V.1
Meuwly, M.2
Karplus, M.3
-
40
-
-
24344456625
-
Study of the insulin dimerization: Binding free energy calculations and per-residue free energy decomposition
-
Zoete V, Meuwly M, Karplus M: Study of the insulin dimerization: binding free energy calculations and per-residue free energy decomposition. Protein Struct. Funct. Bioinf. 61, 79-93 (2005).
-
(2005)
Protein Struct. Funct. Bioinf.
, vol.61
, pp. 79-93
-
-
Zoete, V.1
Meuwly, M.2
Karplus, M.3
-
41
-
-
33750539273
-
Importance of individual side chains for the stability of a protein fold: Computational alanine scanning of the insulin monomer
-
DOI 10.1002/jcc.20512 (Epub ahead of print)
-
Zoete V, Meuwly M: Importance of individual side chains for the stability of a protein fold: computational alanine scanning of the insulin monomer. J. Comput. Chem. DOI 10.1002/jcc.20512 (2006) (Epub ahead of print).
-
(2006)
J. Comput. Chem.
-
-
Zoete, V.1
Meuwly, M.2
-
42
-
-
0035935230
-
Spectroscopic and molecular dynamics simulation studies of the interaction of insulin with glucose
-
Falconi M, Bozzi M, Paci M et al.: Spectroscopic and molecular dynamics simulation studies of the interaction of insulin with glucose. Int. J. Biol Macromol 29(3), 161-168 (2001).
-
(2001)
Int. J. Biol Macromol
, vol.29
, Issue.3
, pp. 161-168
-
-
Falconi, M.1
Bozzi, M.2
Paci, M.3
-
43
-
-
0022402315
-
The thermodynamics of bovine and porcine insulin and proinsulin association determined by concentration difference specrroscopy
-
Strazza S, Hunter R, Walker E, Darnall DW: The thermodynamics of bovine and porcine insulin and proinsulin association determined by concentration difference specrroscopy. Arch. Biochem. Biophys. 238, 30-42 (1985).
-
(1985)
Arch. Biochem. Biophys.
, vol.238
, pp. 30-42
-
-
Strazza, S.1
Hunter, R.2
Walker, E.3
Darnall, D.W.4
-
44
-
-
84873689921
-
-
Koch M: Masters Thesis, University of Basel (2006)
-
Koch M: Masters Thesis, University of Basel (2006).
-
-
-
-
45
-
-
33646582037
-
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
-
Farokhzad C, Cheng J, Teply BA et al.: Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc. Natl Acad Sci. USA 103, 6315-6320 (2006).
-
(2006)
Proc. Natl Acad Sci. USA
, vol.103
, pp. 6315-6320
-
-
Farokhzad, C.1
Cheng, J.2
Teply, B.A.3
-
46
-
-
26844435173
-
Glucose sensitivity through oxidation responsiveness. An example of cascade-responsive nano-sensors
-
Rehor B, Botterhuis NE, Hubbell JA, Sommerdijk NAJM, Tirelli N. Glucose sensitivity through oxidation responsiveness. An example of cascade-responsive nano-sensors. J. Mater. Chem. 15, 4006-4009 (2005).
-
(2005)
J. Mater. Chem.
, vol.15
, pp. 4006-4009
-
-
Rehor, B.1
Botterhuis, N.E.2
Hubbell, J.A.3
Sommerdijk, N.A.J.M.4
Tirelli, N.5
|