Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region

Gene

Volumn 404, Issue 1-2, 2007, Pages 110-116

  Bredow, Sebastian ^a   Juri, Daniel E ^a   Cardon, Karen ^a   Tesfaigzi, Yohannes ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

Airway epithelium; bcl 2 gene transcription; Lung; Negative regulatory element; Promoter activity

Indexed keywords

CCAAT BINDING FACTOR; PROTEIN BCL 2; PROTEIN P53;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EPITHELIUM CELL; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE REPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; RESPIRATORY EPITHELIUM; TATA BOX;

ANIMALS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HUMANS; MICE; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 35248897733     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2007.09.005     Document Type: Article

References (28)

1. Bredow S., Lewin M., Hofmann B., Marecos E., and Weissleder R. Imaging of tumour neovasculature by targeting the TGF-beta binding receptor endoglin. Eur. J. Cancer 36 (2000) 675-6681
2. Budhram-Mahadeo V., Morris P.J., Smith M.D., Midgley C.A., Boxer L.M., and Latchman D.S. p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. J. Biol. Chem. 274 (1999) 15237-15244
3. Catz S.D., and Johnson J.L. Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer. Oncogene 20 (2001) 7342-7351
4. Chen H.M., and Boxer L.M. Pi 1 binding sites are negative regulators of bcl-2 expression in pre-B cells. Mol. Cell. Biol. 15 (1995) 3840-3847
5. el-Deiry W.S., Kern S.E., Pietenpol J.A., Kinzler K.W., and Vogelstein B. Definition of a consensus binding site for p53. Nat. Genet. 1 (1992) 45-49
6. Harn H.J., et al. Down regulation of bcl-2 by p53 in nasopharyngeal carcinoma and lack of detection of its specific t(14;18) chromosomal translocation in fixed tissues. Histopathology 28 (1996) 317-323
7. Harris J.F., et al. Bcl-2 sustains increased mucous and epithelial cell numbers in metaplastic airway epithelium. Am. J. Respir. Crit. Care Med. 171 (2005) 764-772
8. Hockenbery D., Nunez G., Milliman C., Schreiber R.D., and Korsmeyer S.J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348 (1990) 334-336
9. Hoehner J.C., Gestblom C., Olsen L., and Pahlman S. Spatial association of apoptosis-related gene expression and cellular death in clinical neuroblastoma. Br. J. Cancer 75 (1997) 1185-1194
10. Imbriano C., et al. Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. Mol. Cell. Biol. 25 (2005) 3737-3751
11. Lang G., Gombert W.M., and Gould H.J. A transcriptional regulatory element in the coding sequence of the human bcl-2 gene. Immunology 114 (2005) 25-36
12. Lee W.Y., Jin Y.T., and Tzeng C.C. Reciprocal expression of Bcl-2 and p53 in breast ductal carcinoma. Anticancer Res. 16 (1996) 3007-3312
13. Manion M.K., and Hockenbery D.M. Targeting BCL-2-related proteins in cancer therapy. Cancer Biol. Ther. 2 (2003) S105-S114
14. Miyashita T., Harigai M., Hanada M., and Reed J.C. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res. 54 (1994) 3131-3135
15. Miyashita T., Krajewski S., Krajewska M., Wang H.G., Lin H.K., Liebermann D.A., Hoffman B., and Reed J.C. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9 (1994) 1799-1805
16. Pugazhenthi S., et al. Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein. J. Biol. Chem. 274 (1999) 27529-27535
17. Pugazhenthi S., et al. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J. Biol. Chem. 275 (2000) 10761-10766
18. Reed J.C. Bcl-2 family proteins. Oncogene 17 (1998) 3225-3236
19. Reed J.C. Dysregulation of apoptosis in cancer. J. Clin. Oncol. 17 (1999) 2941-2953
20. Seto M., et al. Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. Embo J. 7 (1988) 123-131
21. Tesfaigzi Y. Roles of apoptosis in airway epithelia. Am. J. Respir. Cell. Mol. Biol. 34 (2006) 537-547
22. Tesfaigzi Y., Fischer M.J., Martin A.J., and Seagrave J. Bcl-2 in LPS- and allergen-induced hyperplastic mucous cells in airway epithelia of Brown Norway rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 279 (2000) L1210-L1217
23. Vaux D.L., Cory S., and Adams J.M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335 (1988) 440-442
24. Webb A., et al. BCL-2 antisense therapy in patients with non-Hodgkin lymphoma. Lancet 349 (1997) 1137-1141
25. Wilson B.E., Mochon E., and Boxer L.M. Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. Mol. Cell. Biol. 16 (1996) 5546-5556
26. Wu Y., Mehew J.W., Heckman C.A., Arcinas M., and Boxer L.M. Negative regulation of bcl-2 expression by p53 in hematopoietic cells. Oncogene 20 (2001) 240-251
27. You Y., Richer E.J., Huang T., and Brody S.L. Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population. Am. J. Physiol. Lung Cell. Mol. Physiol. 283 (2002) L1315-L1321
28. Young R.L., and Korsmeyer S.J. A negative regulatory element in the bcl-2 5′ -untranslated region inhibits expression from an upstream promoter. Mol. Cell. Biol. 13 (1993) 3686-3697