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Volumn 82, Issue 5, 2007, Pages 555-565

Factors affecting drug concentrations and QT interval during thioridazine therapy

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMLODIPINE; ANTIDEPRESSANT AGENT; ATENOLOL; ATORVASTATIN; BENDROFLUMETHIAZIDE; BENZODIAZEPINE DERIVATIVE; BUMETANIDE; CAPTOPRIL; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; DILTIAZEM; ENALAPRIL; FLUOXETINE; FUROSEMIDE; GLICLAZIDE; HYPNOTIC AGENT; MESORIDAZINE; MOOD STABILIZER; NEUROLEPTIC AGENT; NIFEDIPINE; PAROXETINE; PROPRANOLOL DERIVATIVE; SIMVASTATIN; SULFORIDAZINE; SULFOXIDE; THIORIDAZINE; THYROXINE; TOLBUTAMIDE; UNINDEXED DRUG;

EID: 35248888219     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/sj.clpt.6100195     Document Type: Article
Times cited : (35)

References (36)
  • 1
    • 0028179941 scopus 로고
    • QT interval prolongation and ventricular arrhythmias
    • Thomas, S.H.L. QT interval prolongation and ventricular arrhythmias. Adverse Drug React. Toxicol. Rev. 13, 77-102 (1994).
    • (1994) Adverse Drug React. Toxicol. Rev , vol.13 , pp. 77-102
    • Thomas, S.H.L.1
  • 2
    • 0029801375 scopus 로고    scopus 로고
    • Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans
    • Hartigan-Go, K., Bateman, D.N., Nyberg, G., Martensson, E. & Thomas, S.H.L. Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans. Clin. Pharmacol. Ther. 60, 543-553 (1996).
    • (1996) Clin. Pharmacol. Ther , vol.60 , pp. 543-553
    • Hartigan-Go, K.1    Bateman, D.N.2    Nyberg, G.3    Martensson, E.4    Thomas, S.H.L.5
  • 3
    • 0000193336 scopus 로고
    • Thioridazine hydrochloride (Mellaril): Its effect on the electrocardiogram and a report of two fatalities with electrocardiographic abnormalities
    • Kelly, H.Q., Fay, J.E. & Laverty, F.G. Thioridazine hydrochloride (Mellaril): its effect on the electrocardiogram and a report of two fatalities with electrocardiographic abnormalities. CMAJ 89, 546-554 (1963).
    • (1963) CMAJ , vol.89 , pp. 546-554
    • Kelly, H.Q.1    Fay, J.E.2    Laverty, F.G.3
  • 4
    • 0025874578 scopus 로고
    • A survey of sudden death associated with the use of antipsychotic or antidepressant drugs: 49 cases in Finland
    • Mehtonen, O.P., Aranko, K., Malkonen, L. & Vapaatalo, H. A survey of sudden death associated with the use of antipsychotic or antidepressant drugs: 49 cases in Finland. Acta Psychiatr. Scand. 84, 58-64 (1991).
    • (1991) Acta Psychiatr. Scand , vol.84 , pp. 58-64
    • Mehtonen, O.P.1    Aranko, K.2    Malkonen, L.3    Vapaatalo, H.4
  • 7
    • 0033052403 scopus 로고    scopus 로고
    • Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current
    • Drolet, B. et al. Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current. J. Pharmacol. Exp. Ther. 288, 1261-1269 (1999).
    • (1999) J. Pharmacol. Exp. Ther , vol.288 , pp. 1261-1269
    • Drolet, B.1
  • 9
    • 0027517286 scopus 로고
    • Metabolism of piperidine-type phenothiazine antipsychotic agents. IV. Thioridazine in dog, man and rat
    • Lin, G., Hawes, E.M., Mc Kay, G., Korchinski, E.D. & Midha, K.K. Metabolism of piperidine-type phenothiazine antipsychotic agents. IV. Thioridazine in dog, man and rat. Xenobiotica 23, 1059-1074 (1993).
    • (1993) Xenobiotica , vol.23 , pp. 1059-1074
    • Lin, G.1    Hawes, E.M.2    Mc Kay, G.3    Korchinski, E.D.4    Midha, K.K.5
  • 10
    • 0026086815 scopus 로고
    • Plasma levels of thioridazine and metabolites are influenced by the debrisoquine hydroxylation phenotype
    • Von Bahr, C., Movin, G. & Nordin, C. Plasma levels of thioridazine and metabolites are influenced by the debrisoquine hydroxylation phenotype. Clin. Pharmacol. Ther. 49, 234-240 (1991).
    • (1991) Clin. Pharmacol. Ther , vol.49 , pp. 234-240
    • Von Bahr, C.1    Movin, G.2    Nordin, C.3
  • 11
    • 0029897864 scopus 로고    scopus 로고
    • Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin
    • Eap, C.B. et al. Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin. Clin. Pharmacol. Ther. 59, 322-331 (1996).
    • (1996) Clin. Pharmacol. Ther , vol.59 , pp. 322-331
    • Eap, C.B.1
  • 12
    • 0038469903 scopus 로고    scopus 로고
    • Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype
    • Berecz, R., de la Rubia, A., Dorado, P., Fernandez-Salguero, P., Dahl, M.L. & Llerena, A. Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype. Eur. J. Clin. Pharmacol. 59, 45-50 (2003).
    • (2003) Eur. J. Clin. Pharmacol , vol.59 , pp. 45-50
    • Berecz, R.1    de la Rubia, A.2    Dorado, P.3    Fernandez-Salguero, P.4    Dahl, M.L.5    Llerena, A.6
  • 13
    • 0032699804 scopus 로고    scopus 로고
    • Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients
    • Carillo, J.A. et al. Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients. J. Clin. Psychopharmacol. 19, 494-499 (1999).
    • (1999) J. Clin. Psychopharmacol , vol.19 , pp. 494-499
    • Carillo, J.A.1
  • 14
    • 33344460427 scopus 로고    scopus 로고
    • Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine
    • Wojcikowski, J., Maurel, P. & Daniel, W.A. Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine. Drug Metab. Dispos. 34, 471-476 (2006).
    • (2006) Drug Metab. Dispos , vol.34 , pp. 471-476
    • Wojcikowski, J.1    Maurel, P.2    Daniel, W.A.3
  • 15
    • 0003175813 scopus 로고    scopus 로고
    • QT interval prolongation with antipsychotics
    • Committee on Safety of Medicines
    • Committee on Safety of Medicines. QT interval prolongation with antipsychotics. Current Problems in Pharmacovigilance 27, 4 (2001).
    • (2001) Current Problems in Pharmacovigilance , vol.27 , pp. 4
  • 16
    • 0028275352 scopus 로고
    • Phenotype/genotype relationships for the cytochrome P450 enzyme CYP2D6 in rheumatoid arthritis: Influence of drug therapy and disease activity
    • Beyeler, C., Daly, A.K., Armstrong, M., Astbury, C., Bird, H.A. & Idle, J.R. Phenotype/genotype relationships for the cytochrome P450 enzyme CYP2D6 in rheumatoid arthritis: influence of drug therapy and disease activity. J. Rheumatol. 21, 1034-1039 (1994).
    • (1994) J. Rheumatol , vol.21 , pp. 1034-1039
    • Beyeler, C.1    Daly, A.K.2    Armstrong, M.3    Astbury, C.4    Bird, H.A.5    Idle, J.R.6
  • 17
    • 0024559582 scopus 로고
    • A fixed dose study of the plasma concentration and clinical effects of thioridazine and its major metabolites
    • Cohen, B.M., Lipinski, J.F. & Waternaux, C. A fixed dose study of the plasma concentration and clinical effects of thioridazine and its major metabolites. Psychopharmacology 97, 481-488 (1989).
    • (1989) Psychopharmacology , vol.97 , pp. 481-488
    • Cohen, B.M.1    Lipinski, J.F.2    Waternaux, C.3
  • 18
    • 0021825307 scopus 로고
    • Inhibition of desmethylimipramine 2′-hydroxylation by drugs in human liver microsomes
    • Von Bahr, C. et al. Inhibition of desmethylimipramine 2′-hydroxylation by drugs in human liver microsomes. Biochem. Pharmacol. 24, 2501-2505 (1985).
    • (1985) Biochem. Pharmacol , vol.24 , pp. 2501-2505
    • Von Bahr, C.1
  • 19
    • 0026505577 scopus 로고
    • Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitryptiline
    • Baumann, P. et al. Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitryptiline. Ther. Drug Monit. 14, 1-8 (1992).
    • (1992) Ther. Drug Monit , vol.14 , pp. 1-8
    • Baumann, P.1
  • 20
    • 0035187486 scopus 로고    scopus 로고
    • Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes
    • Llerena, A., Berecz, R., de la Rubia, A., Fernandez-Salguero, P. & Dorado, P. Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes. Ther. Drug Monit. 14, 616-620 (2001).
    • (2001) Ther. Drug Monit , vol.14 , pp. 616-620
    • Llerena, A.1    Berecz, R.2    de la Rubia, A.3    Fernandez-Salguero, P.4    Dorado, P.5
  • 21
    • 0034712552 scopus 로고    scopus 로고
    • QTc interval abnormalities and psychotropic drug therapy in psychiatric patients
    • Reilly, J.G., Ayis, S., Ferrier, I.N. & Thomas, S.H.L. QTc interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet 355, 1048-1052 (2000).
    • (2000) Lancet , vol.355 , pp. 1048-1052
    • Reilly, J.G.1    Ayis, S.2    Ferrier, I.N.3    Thomas, S.H.L.4
  • 22
    • 0032805239 scopus 로고    scopus 로고
    • Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test
    • Tantcheva-Poor, I., Zaigler, M., Rietbrock, S. & Fuhr, U. Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test. Pharmacogenetics 9, 31-144 (1999).
    • (1999) Pharmacogenetics , vol.9 , pp. 31-144
    • Tantcheva-Poor, I.1    Zaigler, M.2    Rietbrock, S.3    Fuhr, U.4
  • 23
    • 3543019165 scopus 로고    scopus 로고
    • Time response of cytochrome P450 1A2 activity on cessation of heavy smoking
    • Faber, M.S. & Fuhr, U. Time response of cytochrome P450 1A2 activity on cessation of heavy smoking. Clin. Pharm. Ther. 76, 178-184 (2004).
    • (2004) Clin. Pharm. Ther , vol.76 , pp. 178-184
    • Faber, M.S.1    Fuhr, U.2
  • 24
    • 0028898044 scopus 로고
    • Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: Potent inhibition by fluvoxamine
    • Rasmussen, B.B. et al. Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine. Br. J. Clin. Pharmacol. 39, 151-159 (1995).
    • (1995) Br. J. Clin. Pharmacol , vol.39 , pp. 151-159
    • Rasmussen, B.B.1
  • 25
    • 0036212577 scopus 로고    scopus 로고
    • Low daily 10 mg and 20 mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19)
    • Christensen, M. et al. Low daily 10 mg and 20 mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19). Clin. Pharm. Ther. 71, 141-152 (2002).
    • (2002) Clin. Pharm. Ther , vol.71 , pp. 141-152
    • Christensen, M.1
  • 26
    • 0021247782 scopus 로고
    • Thioridazine-5-sulfoxide cardiotoxicity in the isolated, perfused rat heart
    • Hale, P.W. Jr & Poklis, A. Thioridazine-5-sulfoxide cardiotoxicity in the isolated, perfused rat heart. Toxicol. Lett. 21, 1-8 (1984).
    • (1984) Toxicol. Lett , vol.21 , pp. 1-8
    • Hale, P.W.J.1    Poklis, A.2
  • 28
    • 0021963450 scopus 로고
    • Thioridazine toxicity- an experimental cardiovascular study of thioridazine and its major metabolites in overdose
    • Heath, A. Thioridazine toxicity- an experimental cardiovascular study of thioridazine and its major metabolites in overdose. Vet. Hum. Toxicol. 27, 100-105 (1985).
    • (1985) Vet. Hum. Toxicol , vol.27 , pp. 100-105
    • Heath, A.1
  • 29
    • 0027368584 scopus 로고
    • Determination of thioridazine enantiomers in human serum by sequential achiral and chiral high-performance liquid chromatography
    • Jortani, S.A. & Poklis, A. Determination of thioridazine enantiomers in human serum by sequential achiral and chiral high-performance liquid chromatography. J. Anal. Toxicol. 17, 374-377 (1993).
    • (1993) J. Anal. Toxicol , vol.17 , pp. 374-377
    • Jortani, S.A.1    Poklis, A.2
  • 30
    • 0022898322 scopus 로고
    • The biotransformation of thioridazine to thioridazine 5-sulfoxide stereoisomers in phenobarbital induced rats
    • Hale, P.W. Jr & Poklis, A. The biotransformation of thioridazine to thioridazine 5-sulfoxide stereoisomers in phenobarbital induced rats. Eur. J. Drug Metab. Pharmacokinet. 11, 2839 (1986).
    • (1986) Eur. J. Drug Metab. Pharmacokinet , vol.11 , pp. 2839
    • Hale Jr, P.W.1    Poklis, A.2
  • 31
    • 35248875421 scopus 로고    scopus 로고
    • Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses
    • submitted
    • Salih, I.S.M., Thanacoody, R.H..K., McKay, G.A. & Thomas, S.H.L. Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses. Clin. Pharmacol. Ther. (submitted).
    • Clin. Pharmacol. Ther
    • Salih, I.S.M.1    Thanacoody, R.H.K.2    McKay, G.A.3    Thomas, S.H.L.4
  • 32
    • 0036903984 scopus 로고    scopus 로고
    • QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients
    • Llerena, A., Berecz, R., la Rubia, A. & Dorado, P. QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients. J. Psychopharmacol. 16, 359-362 (2002).
    • (2002) J. Psychopharmacol , vol.16 , pp. 359-362
    • Llerena, A.1    Berecz, R.2    la Rubia, A.3    Dorado, P.4
  • 33
    • 1642579574 scopus 로고    scopus 로고
    • A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition
    • Harrigan, E.P. et al. A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition. J. Clin. Psychopharmacol. 24, 62-69 (2004).
    • (2004) J. Clin. Psychopharmacol , vol.24 , pp. 62-69
    • Harrigan, E.P.1
  • 34
    • 0036219021 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: An update
    • Hemeryck, A. & Belpaire, F.M. Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: an update. Curr. Drug Metab. 3, 13-37 (2002).
    • (2002) Curr. Drug Metab , vol.3 , pp. 13-37
    • Hemeryck, A.1    Belpaire, F.M.2
  • 36
    • 0642284608 scopus 로고    scopus 로고
    • Daly, A.K., Monkman, S.C., Smart, J., Steward, A. & Cholerton, S. Analysis of cytochrome P450 polymorphisms. Methods in Molecular Biology 107: Cytochrome P450 Protocols (eds. IR Phillips and EA Shephard) Publisher: Humana Press Inc., Totowa, NJ, 405-422.
    • Daly, A.K., Monkman, S.C., Smart, J., Steward, A. & Cholerton, S. Analysis of cytochrome P450 polymorphisms. Methods in Molecular Biology vol 107: Cytochrome P450 Protocols (eds. IR Phillips and EA Shephard) Publisher: Humana Press Inc., Totowa, NJ, 405-422.


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