Efficacy of a monthly compared to 3-monthly depot GnRH analogue (goserelin) in the treatment of children with central precocious puberty

Hormone Research

Volumn 68, Issue 4, 2007, Pages 157-163

  Isaac, H ^a   Patel, L ^a,b   Meyer, S ^b   Hall, C M ^a   Cusick, C ^a   Price, D A ^a   Clayton, P E ^a,b  

^a ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Body mass index; Early puberty; Obesity; Pubertal suppression

Indexed keywords

ESTRADIOL; GOSERELIN; LUTEINIZING HORMONE; TESTOSTERONE; DRUG DERIVATIVE; GONADORELIN;

ACNE; ARTICLE; BEHAVIOR CHANGE; BODY HEIGHT; BODY MASS; BREAST; CLINICAL FEATURE; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DRUG EFFECT; DRUG EFFICACY; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; GROWTH INHIBITION; HAIR GROWTH; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MENSTRUATION; MOOD CHANGE; ODOR; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; TESTIS; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; CHILD; DELAYED RELEASE FORMULATION; DRUG ADMINISTRATION; EVALUATION; GROWTH, DEVELOPMENT AND AGING; TREATMENT OUTCOME;

BODY HEIGHT; BODY MASS INDEX; CHILD; DELAYED-ACTION PREPARATIONS; DRUG ADMINISTRATION SCHEDULE; FEMALE; GONADOTROPIN-RELEASING HORMONE; GOSERELIN; GROWTH AND DEVELOPMENT; HUMANS; MALE; PUBERTY, PRECOCIOUS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 35248855119     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000100579     Document Type: Article

References (24)

1. Conn PM, Crowley WF: Gonadotropin-releasing hormone and its analogues. N Engl J Med 1991;324:93-103.
2. Badaru A, Wilson DM, Bachrach LK, Fechner P, Gandrud LM, Durham E, Wintergerst K, Chi C, Klein KO, Neely KE: Sequential comparisons of one-month and three-month depot leuprolide regimens in central precocious puberty. J Clin Endocrinol Metab 2006;91:1862-1867.
3. Carel JC, Lahlou N, Jaramillo O, Montauban V, Teinturier C, Colle M, Lucas C, Chaussain JL: Treatment of central precocious puberty by subcutaneous injections of leuprorelin 3-month depot (11.25 mg). J Clin Endocrinol Metab 2002;87:4111-4116.
4. Carel JC, Blumberg J, Seymour C, Adamsbaum C, Lahlou N, Triptorelin 3-Month CPP Study Group: Three-month sustained-release triptorelin (11.25 mg) in the treatment of central precocious puberty. Eur J Endocrinol 2006;154:119-124.
5. Paterson WF, McNeill E, Reid S, Hollman AS, Donaldson MD: Efficacy of Zoladex LA (goserelin) in the treatment of girls with central precocious or early puberty. Arch Dis Child 1998;79:323-327.
6. Trueman JA, Tillmann V, Cusick CF, Foster P, Patel L, Hall CM, Price DA, Clayton PE: Suppression of puberty with long-acting goserelin (Zoladex LA): effect on gonadotrophin response to GnRH in the first treatment cycle. Clin Endocrinol 2002;57:223-230.
7. Arrigo T, De Luca F, Antoniazzi F, Galluzzi F, Segni M, Rosano M, Messina MF, Lombardo F: Reduction of baseline body mass index under gonadotropin-suppressive therapy in girls with idiopathic precocious puberty. Eur J Endocrinol 2004;150:533-537.
8. Feuillan PP, Jones JV, Barnes K, Oerter-Klein K, Cutler GB Jr: Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long-term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty. J Clin Endocrinol Metab 1999;84:44-49.
9. Heger S, Partsch CJ, Sippell WG: Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function. J Clin Endocrinol Metab 1999;84:4583-4590.
10. Palmert MR, Mansfield MJ, Crowley WF Jr, Crigler JF Jr, Crawford JD, Boepple PA: Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty. J Clin Endocrinol Metab 1999;84:4480-4488.
11. Lazar L, Kauli R, Pertzelan A, Phillip M: Gonadotropin - suppressive therapy in girls with early and fast puberty affects the pace of puberty but not the total pubertal growth or final height. J Clin Endocrinol Metab 2002;87:2090-2094.
12. Neely EK, Wilson DM, Lee PA, Stene M, Hintz RL: Spontaneous serum gonadotropin concentrations in the evaluation of precocious puberty. J Pediatr 1995;127:47-52.
13. Freeman JV, Cole TJ, Chinn S, Jones EM, Preece MA: Cross sectional stature and weight reference curves for the UK, 1990. Arch Dis Child 1995;73:17-24.
14. Cole TJ, Freeman JV, Preece MA: Body mass index reference curves for the UK, 1990. Arch Dis Child 1995;73:25-29.
15. Bouvattier C, Lahlou N, Roger M, Bougnères P: Hyperleptinaemia is associated with impaired gonadotrophin response to GnRH during late puberty in obese girls, not boys. Eur J Endocrinol 1998;138:653-658.
16. Weise M, Flor A, Barnes KM, Cutler GB Jr, Baron J: Determinants of growth during gonadotropin-releasing hormone analog therapy for precocious puberty. J Clin Endocrinol Metab 2004;89:103-107.
17. Walvoord EC, Pescovitz OH: Combined use of growth hormone and gonadotropin-releasing hormone analogues in precocious puberty: theoretic and practical considerations. Pediatrics 1999;104:1010-1014.
18. Oostdijk W, Rikken B, Schreuder S, Otten B, Odink R, Rouwe C, Jansen M, Gerver WJ, Waelkens J, Drop S: Final height in central precocious puberty after long term treatment with a slow release GnRH agonist. Arch Dis Child 1996;75:292-297.
19. Paterson WF, McNeill E, Young D, Donaldson MDC: Auxological outcome and time to menarche following long-acting goserelin therapy in girls with central precocious or early puberty. Clin Endocrinol 2004;61:626-634.
20. van der Sluis IM, Boot AM, Krenning EP, Drop SLS, de Muinck Keizer-Schrama SMPF: Longitudinal follow-up of bone density and body composition in children with precocious or early puberty before, during and after cessation of GnRH agonist therapy. J Clin Endocrinol Metab 2002;87:506-512.
21. Kaplowitz PB, Slora EJ, Wasserman RC, Pedlow SE, Herman-Giddens ME: Earlier onset of puberty in girls: relation to increased body mass index and race. Pediatrics 2001;108:347-353.
22. Pietrobelli A, Faith MS, Allison DB, Gallagher D, Chiumello G, Heymsfield SB: Body mass index as a measure of adiposity among children and adolescents: a validation study. J Pediatr 1998;132:204-210.
23. Boot AM, de Muinck Keizer-Schrama SMPF, Pols HAP, Krenning EP, Drop SLS: Bone mineral density and body composition before and during treatment with gonadotropin-releasing hormone agonist in children with central precocious and early puberty. J Clin Endocrinol Metab 1998;83:370-373.
24. Brito VN, Latronico AC, Arnhold IJP, Mendonca BB: A single luteinising hormone determination 2 h after depot leuprolide is useful for therapy monitoring of gonadotropin-dependent precocious puberty in girls. J Clin Endocrinol Metab 2004;89:4338-4342.