In vitro characterization of the Gd complex of [2,6-pyridinediylbis(methylene nitrilo)] tetraacetic acid (PMN-tetraacetic acid) and of its Eu analogue, suitable bimodal contrast agents for MRI and optical imaging

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6230-6233

  Laurent, S ^a   Vander Elst, L ^a   Wautier, M ^a   Galaup, C ^b   Muller, R N ^a   Picard, C ^b  

^a NMR   (Belgium)

^b UPS)   (France)

Author keywords

Eu complex; Gd complex; MRI; Optical imaging

Indexed keywords

[2,6 PYRIDINEDIYLBIS(METHYLENE NITRILO)]TETRAACETIC ACID; EUROPIUM; EUROPIUM [2,6 PYRIDINEDIYLBIS(METHYLENE NITRILO)]TETRAACETATE; GADODIAMIDE; GADOLINIUM [2,6 PYRIDINEDIYLBIS(METHYLENE NITRILO)]TETRAACETATE; GADOLINIUM CHELATE; GADOLINIUM PENTETATE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; SERUM ALBUMIN; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; LUMINESCENCE; NUCLEAR MAGNETIC RESONANCE IMAGING; ROOM TEMPERATURE; THERMODYNAMICS;

ACETIC ACIDS; CONTRAST MEDIA; EUROPIUM; GADOLINIUM; LUMINESCENT AGENTS; MAGNETIC RESONANCE IMAGING; MOLECULAR STRUCTURE; NITRILES; ORGANOMETALLIC COMPOUNDS; PYRIDINES;

EID: 35148895019     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.027     Document Type: Article

References (23)

1. In: Toth E., and Merbach A.E. (Eds). The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging (2001), Wiley, Chichester
2. Huber M.M., Staubli A.B., Kustedjo K., Gray M.H., Shih J., Fraser S.E., Jacobs R.E., and Meade T.J. Bioconjugate Chem. 9 (1998) 242
3. Mukkala V.-M., Sund C., Kwiatkowski M., Pasanen P., Hogberg M., Kankare J., and Takalo H. Helv. Chim. Acta 75 (1992) 1621
4. em (relative intensity) 580 (2.0), 592 (31.3), 616 (100), 651 (3.6), 693 (68.1).
5. Solomon I. Phys. Rev. 99 (1955) 559
6. Bloembergen N. J. Chem. Phys. 27 (1957) 572
7. Freed J.H. J. Chem. Phys. 68 (1978) 4034
8. Micskei K., Helm L., Brucher E., and Merbach A.E. Inorg. Chem. 32 (1993) 3844
9. Gonzalez G., Powell D.H., Tissieres V., and Merbach A.E. J. Phys. Chem. 98 (1994) 53
10. Vander Elst L., Maton F., Laurent S., Seghi F., Chapelle F., and Muller R.N. Magn. Reson. Med. 38 (1997) 604
11. Botteman F., Nicolle G., Vander Elst L., Laurent S., Merbach A.E., and Muller R.N. Eur. J. Inorg. Chem. (2002) 2686
12. 2O for the lock.
13. Laurent S., Vander Elst L., and Muller R.N. Contrast Med. Mol. Imaging 1 (2006) 128
14. Chellquist E.M., and Searle R.J. Pharm. Biomed. Anal. 11 (1993) 985
15. Laurent S., Vander Elst L., Copoix F., and Muller R.N. Invest. Radiol. 36 (2001) 115
16. Kropp J.L., and Windsor M.W. J. Chem. Phys. 42 (1965) 1599
17. D2O) - 0.31, with τ in ms. Supkowski, R. M.; Horrocks, W. D. W., Jr. Inorg. Chim. Acta 2002, 340, 44.
18. Eu (0.09) was determined following the procedure described by Verhoeven et al. Werts, M. H. V.; Jukes, R. T. F.; Verhoeven, J. W. Phys. Chem. Chem. Phys. 2002, 4, 1542.
19. Alpha B., Balzani V., Lehn J.-M., Perathoner S., and Sabbatini N. Angew. Chem., Int. Ed. Engl. 26 (1987) 1266
20. Takalo H., Mukkala V.-M., Mikola H., Liitti P., and Hemmila I. Bioconjugate Chem. 5 (1994) 278
21. Dickins R.S., Gunnlaugsson T., Parker D., and Peacock R.D. Chem. Commun. (1998) 1643
22. Werts M.H.V., Verhoeven J.W., and Hofstraat J.W. J. Chem. Soc., Perkin Trans. 2 (2000) 433
23. Wedeking P., Kumar K., and Tweedle M.F. Magn. Reson. Imaging 10 (1992) 641