Wound healing activity of Carica papaya L. In experimentally induced diabetic rats

Indian Journal of Experimental Biology

Volumn 45, Issue 8, 2007, Pages 739-743

  Nayak, B Shivananda ^a   Pereira, Lexley Pinto ^a   Maharaj, Dale ^a  

^a UNIVERSITY OF THE WEST INDIES   (Trinidad and Tobago)

Author keywords

Diabetic; Excision wound; Hydroxyproline; Incision wound

Indexed keywords

ANIMALIA; CARICA PAPAYA; RATTUS;

ANTIINFECTIVE AGENT; PLANT EXTRACT;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; INJURY; MALE; MICROBIOLOGY; PAPAYA; RAT; SPRAGUE DAWLEY RAT; WOUND HEALING;

ANIMALS; ANTI-BACTERIAL AGENTS; CARICA; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; WOUND HEALING; WOUNDS AND INJURIES;

EID: 35148890179     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Falanga V, The Chronic wound: Impaired wound healing and solutions in the context of wound bed preparation, Blood Cells Mol Dis, 32 (2004) 88.
2. Singer A J & Clark R A, Cutaneous wound healing, N Engl J Med, 341 (1999) 738.
3. Goodson W H & Hunt T K, Studies of wound healing in experimental diabetes Mellitus, J Surg Res, 22 (1977) 221.
4. Chen C F, Chen S M, Chow S Y & Han P W, Protective effects of Carica Papaya Linn on the exogenous gastric ulcer in rats, Am J Chinese Med, 9 (1981) 205.
5. Emeruwa A, Antibacterial substance from Carica Papaya fruit extract, J Natural Prod, 45 (1982) 132.
6. Rimbach G, Guo Q, Akiyama T, Matsugo S, Moini H, Virgili F & Packer L, Ferric nitrilo triacetate induced DNA and protein damage: Inhibitory effect of a fermented papaya preparation, Anticancer Res, 20 (2000) 2907.
7. Gupta O P, Sing S, Bani S, Sharma N, Malhotra S, Gupta B D, Banerjee S K & Handa S S, Anti-inflammatory and antiarthritic activities of silymarinacting through inhibition of 5- lipoxygenease, Phytomedicine, 7 (2000) 21.
8. Dawkins G, Hewitt H, Wint Y, Obiefuna P C & Wint B, Antibacterial effects of Carica papaya fruit on common wound organisms, West Indian Med J, 52 (2003) 290.
9. Mahmood A A, Sidik & Salmah I, Wound Healing Activity of Carica papaya L. Aqueous Leaf Extract in Rats., Int J Molecular Med Ad Sci, 1 (2005) 398.
10. Jalalpure S S, Patil M B, Prakash N S, Hemalatha K & Manvi F V, Hepatoprotective activity of fruits of Piper longum L., Indian J Pharm Sci, 65 (2003) 363.
11. Morton, J J P & Malone M H, Evaluation of vulnerary activity by an open wound procedure in rats, Arch Int Pharmacodyn, 196 (1972) 117.
12. Turner R A, Inflammatory agent in screening methods of pharmacology. 2nd ed. (Academic Press, New York)1965.
13. Neuman R E & Logan M A, The determination of hydroxyproline, J Biol Chem, 184 (1950) 299.
14. Greenhalgh D G, Wound healing and diabetes mellitus, Clinics Plastic Surg, 30 (2003) 37.
15. Reiser K M, Nonenzymatic glycation of collagen in aging and diabetes, Proceedings for the Society of Experimental Biology and Medicine, 218 (1998) 23.
16. Di Girolamo, N, Underwood A, McCluskey PJ & Wakefield D, Functional activity of plasma fibronectin in patients with diabetes mellitus, Diabetes, 42 (1993) 1606.
17. Wall S J, Sampson M J, Levell N & Murphy G, Elevated matrix metalloproteinase-2 and -3 production from human diabetic dermal fibroblasts, Br J Dermatol, 149 (2003) 13.
18. Starley I F, Mohammed P, Schneider G & Bickler S W, The treatment of paediatric burns using topical papaya, Burns, 25 (1999) 636.
19. Mikhal'chik E V, Ivanova A V, Anurov M V, Titkova S M, Pen'kov L Y, Kharaeva Z F & Korkina L G, Wound-healing effect of papaya-based preparation in experimental thermal trauma, Bull Exp Biol Med, 137 (2004) 560.
20. Edwards R & Harding KG, Bacteria and wound healing, Curr Opin Infect Dis, 17 (2004) 91.
21. Sherry S & Fletcher AP, Proteolytic enzymes: a therapeutic evaluation, Clin Pharmacol Ther, 1 (1960) 202.