Construction of polyamine-modified uridine and adenosine derivatives-evaluation of DNA binding capacity and cytotoxicity in vitro

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 23, 2007, Pages 7426-7433

  Ghatnekar, Johannes ^a   Hägerlöf, Margareta ^a   Oredsson, Stina ^a   Alm, Kersti ^a   Elmroth, Sofi K C ^a   Persson, Tina ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Adenosine; Modified nucleoside; Polyamine derivatives; Uridine

Indexed keywords

2 [[BIS (3 AMINOPROPYL)AMINO] ACETAMIDO 1 PROPYNYL]ADENOSINE; 5 [[BIS(3 AMINOPROPYL)AMINO]ACETAMIDO 1 PROPYNYL]URIDINE; ADENOSINE DERIVATIVE; POLYAMINE DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ARTICLE; CANCER CELL; CHEMICAL STRUCTURE; CYTOTOXICITY; DNA BINDING; DNA STRUCTURE; GROWTH INHIBITION; HERRING; MELTING POINT; SYNTHESIS; TESTIS;

ADENOSINE; BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CIRCULAR DICHROISM; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; POLYAMINES; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TUMOR CELLS, CULTURED; URIDINE;

CLUPEIDAE;

EID: 35148885337     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.07.030     Document Type: Article

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