Methotrexate versus hydroxycarbamide (hydroxyurea) as a weekly dose to treat moderate-to-severe chronic plaque psoriasis: A comparative study

Journal of Dermatological Treatment

Volumn 18, Issue 5, 2007, Pages 295-300

  Ranjan, Nitin ^a   Sharma, Nand Lal ^a   Shanker, Vinay ^a   Mahajan, Vikram K ^a   Tegta, Gita Ram ^a  

^a INDIRA GANDHI MEDICAL COLLEGE   (India)

Author keywords

Hydroxycarbamide; Methotrexate; Psoriasis; Weekly therapy

Indexed keywords

HYDROXYUREA; METHOTREXATE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DIZZINESS; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRY THROAT; ERYTHEMA; FEMALE; HUMAN; MALE; NAUSEA; PAIN; PERIORBITAL EDEMA; PRIORITY JOURNAL; PSORIASIS; PSORIASIS SEVERITY INDEX; SCORING SYSTEM; SKIN DISEASE; SWELLING; TREATMENT DURATION; TREATMENT OUTCOME; VOMITING; XEROSTOMIA;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; DERMATOLOGIC AGENTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; HYDROXYUREA; MALE; METHOTREXATE; MIDDLE AGED; PSORIASIS; SEVERITY OF ILLNESS INDEX; SKIN; TREATMENT OUTCOME;

EID: 35148882152     PISSN: 09546634     EISSN: 14711753     Source Type: Journal    
DOI: 10.1080/09546630701499291     Document Type: Article

References (22)

1. Green MS, Prystowsky JH, Cohen SR, Cohen JI, Lebwohl MG. Infectious complications of erythrodermic psoriasis. J Am Acad Dermatol. 1996;34:911-14.
2. Leavell UW, Mersack IP, Smith C. Survey of the treatment of psoriasis with hydroxyurea. Arch Dermatol. 1973;107:467.
3. Fredriksson T, Pettersson U. Severe psoriasis - oral therapy with a new retinoid. Dermatologica. 1978;157:238-44.
4. Weinstein GD, Frost P. Methotrexate for psoriasis: A new therapeutic schedule. Arch Dermatol. 1971;103:33-8.
5. Heydendael VMR, Spuls PI, Opmeer BC, de Borgie CAJM, Reitsma JB, Goldschmidt WFM, et al. Methotrexate versus cyclosporine in moderate to severe chronic plaque psoriasis. N Engl J Med. 2003;349:658-65.
6. Sharma VK, Dutta B, Ramam M. Hydroxyurea as an alternative therapy for psoriasis. Indian J Dermatol Venereol Leprol. 2004;70:13-17.
7. Van Dooren-Greebe RJ, Kuijpers ALA, Mulder J, Boo TD, van de Kerkhof PCM.Methotrexate revisited: Effects of longterm treatment in psoriasis. Br J Dermatol. 1994;130:204-10.
8. Layton AM, Sheehan-Dare RA, Goodfield MJD, Cotterill JA. Hydroxyurea in the management of therapy resistant psoriasis. Br J Dermatol. 1989;121:647-53.
9. Moschella SL, Greenwald MA. Psoriasis with hydroxyurea: An 18-month study of 60 patients. Arch Dermatol. 1973;107:363-8.
10. Haustein UF, Rytter M. Methotrexate in psoriasis: 26 years experience with low dose long-term treatment. J Eur Acad Dermatol Venereol. 2000;14:382-8.
11. Kumar B, Saraswat A, Kaur I. Short-term methotrexate therapy in psoriasis: A study of 197 patients. Int J Dermatol. 2002;41:444-8.
12. Collins P, Rogers S. The efficacy of methotrexate in psoriasis: A review of 40 cases. Clin Exp Dermatol. 1992;17:257-60.
13. Lim JT, Tham SN. Methotrexate in the treatment of psoriasis at the National Skin Center, Singapore. Ann Acad Med Singapore. 1994;23:848-51.
14. Sandhu K, Kaur I, Kumar B, Saraswat A. Efficacy and safety of cyclosporine versus methotrexate in severe psoriasis: A study from north India. J Dermatol. 2003;30:458-63.
15. Yarbo JW. Hydroxyurea in the treatments of refractory psoriasis. Lancet. 1969;ii:846-7.
16. Boyd AS, Neldner KH. Hydroxyurea therapy. J Am Acad Dermatol. 1991;25:518-24.
17. Stein KM, Shelly WB, Winberg RA. Hydroxyurea in the treatment of pustular psoriasis. Br J Dermatol. 1971;85:81-5.
18. Smith CH. Use of hydroxyurea in psoriasis. Clin Exp Dermatol. 1999;24:2-6.
19. Hattel T, Søndergaard J. Pustulosis palmaris et plantaris treated with hydroxyurea. Acta Derm Venereol. 1974;54:152-4.
20. Kumar B, Saraswat A, Kaur I. Rediscovering hydroxyurea: Its role in recalcitrant psoriasis. Int J Dermatol. 2001;40:530-4.
21. Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol. 1993;28:466-9.
22. Kumar B, Saraswat A, Kaur I. Mucocutaneous adverse effects of hydroxyurea: A prospective study of 30 psoriasis patients. Clin Exp Dermatol. 2002;27:8-13.