Development and validation of in silico models for estimating drug preformulation risk in PEG400/water and Tween80/water systems

European Journal of Pharmaceutical Sciences

Volumn 32, Issue 3, 2007, Pages 169-181

  Crivori, Patrizia ^a   Morelli, Amedea ^b   Pezzetta, Daniele ^b   Rocchetti, Maurizio ^a   Poggesi, Italo ^a  

^a Accelera   (Italy)

^b Preclinical Development   (Italy)

Author keywords

ACDLabs; ChemGPS; E state indices; Formulation; In silico model; PEG400; PLSD; QSPR; Solubility; Solubility prediction; Tween80; Volsurf

Indexed keywords

AMITRIPTYLINE; BROSTALLICIN; CAMPTOTHECIN; CARBAMAZEPINE; DRUG VEHICLE; ERYTHROMYCIN; HALOPERIDOL; HYDROCORTISONE; IMIPRAMINE; MACROGOL 400; POLYSORBATE 80; QUINIDINE; SILICON DERIVATIVE; SULFAPHENAZOLE; TESTOSTERONE; WARFARIN; WATER;

ACCURACY; ARTICLE; BLOOD LEVEL; CHEMGPS METHOD; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CLINICAL STUDY; CORRELATION ANALYSIS; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG MANUFACTURE; DRUG SOLUBILITY; ELECTROPOLOGICAL STATE INDICES; IN VIVO STUDY; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; PARAMETER; PARTIAL LEAST SQUARES DISCRIMINANT ANALYSIS; PH; PREDICTION; PREFORMULATION; PREFORMULATION RISK; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROCESS DEVELOPMENT; RISK; SOLUBILITY; STATISTICAL ANALYSIS; STRUCTURAL DESCRIPTOR; TECHNIQUE; VALIDITY;

CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; LEAST-SQUARES ANALYSIS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; POLYETHYLENE GLYCOLS; POLYSORBATES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS; SOLUBILITY; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 35148872749     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2007.06.008     Document Type: Article

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