Citicoline is not protective in experimental models of Huntington's disease

Neurobiology of Aging

Volumn 28, Issue 12, 2007, Pages 1944-1946

  Mievis, Stéphane ^a   Levivier, Marc ^a   Vassart, Gilbert ^a   Brotchi, Jacques ^a   Ledent, Catherine ^a   Blum, David ^a,b  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b INSERM   (France)

Author keywords

3 Nitropropionic acid; Citicoline; Huntingtin; Huntington's disease; Quinolinic acid; Striatum

Indexed keywords

3 NITROPROPIONIC ACID; CITICOLINE; HUNTINGTIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; NEUROTOXIN; QUINOLINIC ACID;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DRUG MECHANISM; EXCITOTOXICITY; HUNTINGTON CHOREA; METABOLIC DISORDER; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BEHAVIOR, ANIMAL; CYTIDINE DIPHOSPHATE CHOLINE; DISEASE MODELS, ANIMAL; HUNTINGTON DISEASE; NEUROPROTECTIVE AGENTS; NOOTROPIC AGENTS; RATS; TREATMENT OUTCOME;

EID: 35148866214     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2006.09.011     Document Type: Article

References (4)

1. Aiken C.T., Tobin A.J., and Schweitzer E.S. A cell-based screen for drugs to treat Huntington's disease. Neurobiol Dis 16 (2004) 546-555
2. Bantubungi K., Jacquard C., Greco A., Pintor A., Chtarto A., Tai K., et al. Minocycline in phenotypic models of Huntington's disease. Neurobiol Dis 18 (2005) 206-217
3. Brouillet E., Jacquard C., Bizat N., and Blum D. 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease. J Neurochem 95 (2005) 1521-1540
4. Hurtado O., Moro M.A., Cardenas A., Sanchez V., Fernandez-Tome P., Leza J.C., et al. Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. Neurobiol Dis 18 (2005) 336-345