Efficacy and tolerability of indiplon in older adults with primary insomnia

Sleep Medicine

Volumn 8, Issue 7-8, 2007, Pages 753-759

  Walsh, James K ^a,b   Moscovitch, Adam ^c   Burke, Joshua ^d   Farber, Robert ^d   Roth, Thomas ^e  

^a ST LUKE S HOSPITAL   (United States)

^b SAINT LOUIS UNIVERSITY   (United States)

^c Canadian Sleep Institute   (Canada)

^d NEUROCRINE BIOSCIENCES INC   (United States)

^e HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

Elderly; Hypnotic medication; Indiplon; Primary insomnia; Sleep latency; Sleep maintenance

Indexed keywords

INDIPLON; PLACEBO;

ADULT; AGED; APPETITE; ARTICLE; CHOLECYSTITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG TOLERABILITY; DRUG WITHDRAWAL; ELECTROCARDIOGRAM; FEMALE; HEART ATRIUM FLUTTER; HEART INFARCTION; HEART PALPITATION; HUMAN; HYPERTENSION; HYPOTENSION; INSOMNIA; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; NORTH AMERICA; PARESTHESIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SELF EVALUATION; SIDE EFFECT; SLEEP TIME; SOMNOLENCE; TREATMENT DURATION; WAKEFULNESS;

AGED; AGED, 80 AND OVER; BENZODIAZEPINES; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; SINGLE-BLIND METHOD; SLEEP INITIATION AND MAINTENANCE DISORDERS; THIOPHENES; TREATMENT OUTCOME;

EID: 35148863674     PISSN: 13899457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sleep.2006.12.006     Document Type: Article

References (14)

1. National Institutes of Health State of the Science Conference Statement on Manifestations and Management of Chronic Insomnia in Adults. Sleep 2005;28:1049-1057.
2. Sullivan S.K., Petroski R.E., Verge G., Gross R.S., Foster A.C., and Grigoriadis D.E. Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor. J Pharmacol Exp Ther 311 (2004) 537-546
3. Foster A.C., Pelleymounter M.A., Cullen M.J., Lewis D., Joppa M., Chen T.K., et al. In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine sedative-hypnotic. J Pharmacol Exp Ther 311 (2004) 547-559
4. Jochelson P, Chen TK, Farber R, Campbell B. Lack of pharmacological and pharmacokinetic tolerance following repeat dosing of indiplon (NBI-34060). Poster presentation at the 17th annual meeting of the Associated Professional Sleep Societies, June 3-8, 2003, Chicago, IL.
5. Bozigian H. Chen, TK, Gately N, Boyd M. Indiplon dose-proportional pharmacokinetics. Poster presentation at the annual meeting of the American College of Clinical Pharmacy, October 23-26, 2005, San Francisco, CA.
6. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV, fourth ed. Washington, DC: American Psychiatric Association, 1994.
7. Tyrer P., Murphy S., and Riley P. The Benzodiazepine Withdrawal Symptom Questionnaire. J Affect Disord 19 (1990) 53-61
8. Hochberg Y. A sharper Bonferroni procedure for multiple tests of significance. Biometrika 75 (1988) 800-802
9. Agostini J.V., Leo-Summers L.S., and Inouye S. Cognitive and other adverse effects of diphenhydramine use in hospitalized older patients. Arch Intern Med 161 (2001) 2091-2097
10. Rice V.J., and Snyder H.L. The effects of Benadryl and Hismanal on psychomotor performance and perceived performance. Aviat Space Environ Med 64 (1993) 726-734
11. Berlinger W., Goldberg M., Reynold S., et al. Diphenhydramine: kinetics and psychomotor effects in elderly women. Clin Pharmacol Ther 32 (1982) 387-391
12. Nebes R.D., Pollock B.G., Mulsant B.H., et al. Low-level serum anticholinergicity as a source of baseline cognitive heterogenicity in geriatric depressed patients. Psychopharmacol Bull 33 (1997) 715-720
13. Monane M., Avorn J., Beers M.H., and Everitt D.E. Anticholinergic drug use and bowel function in nursing home patients. Arch Intern Med 153 (1993) 633-638
14. Burns M., Moskowitz H., and Jaffe J. A comparison of the effects of trazodone and amitriptyline on skills performance by geriatric patients. J Clin Psychiatry 47 (1986) 252-254