Carbamazepine and risk of hypothyroidism: A prospective study

Acta Neurologica Scandinavica

Volumn 116, Issue 5, 2007, Pages 317-321

  Simko, J ^a   Horacek, J ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Carbamazepine; Hypothyroidism; Thyrotropin; Thyroxine

Indexed keywords

CARBAMAZEPINE; THYROTROPIN; THYROXINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG EFFECT; FEMALE; HUMAN; HYPOTHYROIDISM; MALE; PROSPECTIVE STUDY; RISK ASSESSMENT; STATISTICAL ANALYSIS; THYROID GLAND; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TREATMENT DURATION; TREATMENT PLANNING;

ADULT; ANTICONVULSANTS; CARBAMAZEPINE; DIABETIC NEUROPATHIES; DOWN-REGULATION; EPILEPSY; HUMANS; HYPOTHYROIDISM; METABOLIC CLEARANCE RATE; MIDDLE AGED; MONITORING, PHYSIOLOGIC; PROSPECTIVE STUDIES; RISK FACTORS; THYROID GLAND; THYROTROPIN; THYROXINE; TRIGEMINAL NEURALGIA;

EID: 35148860663     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2007.00883.x     Document Type: Article

References (29)

1. Holmes GL. Carbamazepine: adverse events. In:Levy RH, Mattson RH, Meldrum BS, Perucca E eds. Antiepileptic drugs. Philadelphia:Lippincott Williams & Wilkins, 2002:285 97
2. Rootwelt K., Ganes T, Johannessen SI. Effect of carbamazepine, phenytoin and phenobarbitone on serum levels of thyroid hormones and thyrotropin in humans. Scand J Clin Lab Invest 1978 38:731 6.
3. Liewendahl K, Majuri H, Helenius T. Thyroid function tests in patients on long-term treatment with various anticonvulsant drugs. Clin Endocrinol 1978 8:185 91.
4. Strandjord RE, Aanderud S, Myking OL, Johannessen SI. The influence of carbamazepine on serum thyroxine and triiodothyronine in patients with epilepsy. Acta Neurol Scand 1981 63:111 21.
5. Bentsen KD, Gram L, Veje A. Serum thyroid hormones and blood folic acid during monotherapy with carbamazepine or valproate. Acta Neurol Scand 1983 67:235 41.
6. Connell JMC, Rapeport WG, Gordon S, Brodie MJ. Changes in circulating thyroid hormones during short-term hepatic enzyme induction with carbamazepine. Eur J Clin Pharmacol 1984 26:453 6.
7. Ericsson UB, Bjerre I, Forsgren M, Ivarsson SA. Thyroglobulin and thyroid hormones in patients on long-term treatment with phenytoin, carbamazepine, and valproic acid. Epilepsia 1985 26:594 6.
8. Tanaka K, Kodama S, Yokoyama S. Thyroid function in children with long-term anticonvulsant treatment. Pediatr Neurosci 1987 13:90 4.
9. Larkin JG, Macphee GJ, Beastall GH, Brodie MJ. Thyroid hormone concentrations in epileptic patients. Eur J Clin Pharmacol 1989 36:213 6.
10. Isojärvi JIT, Pakarinen AJ, Myllylä VV. Thyroid function in epileptic patients treated with carbamazepine. Arch Neurol 1989 46:1175 8.
11. Isojärvi JIT, Pakarinen AJ, Yliparosaari PJ, Myllylä VV. Serum hormones in male epileptic patients receiving anticonvulsant medication. Arch Neurol 1990 47:670 6.
12. Isojärvi JIT, Pakarinen AJ, Myllylä VV. Thyroid function with antiepileptic drugs. Epilepsia 1992 33:142 8.
13. Isojärvi JIT, Airaksinen KEJ, Mustonen JN et al. Thyroid and myocardial function after replacement of carbamazepine by oxcarbamazepine. Epilepsia 1995 36:810 6.
14. Tiihonen M, Liewendahl K, Waltimo O, Ojala M, Valimaki M. Thyroid status of patients receiving long-term anticonvulsant therapy assessed by peripheral parameters: a placebo-controlled thyroxine therapy trial. Epilepsia 1995 36:1118 25.
15. Eirís-Punal J, Del Río-Garma M, Del Río-Garma MC, Lojo-Rocamonde S, Novo-Rodríguez I, Castro-Gago M. Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. Epilepsia 1999 40:1761 6.
16. Isojärvi JIT, Turkka J, Pakarinen AJ, Kotila M, Rättyä J, Myllylä VV. Thyroid function in men taking carbamazepine, oxcarbamazepine, or valproate for epilepsy. Epilepsia 2001 42:930 4.
17. Verrotti A, Basciani F, Morresi S, Morgese G, Chiarelli F. Thyroid hormones in epileptic children receiving carbamazepine and valproid acid. Pediatr Neurol 2001 25:43 6.
18. Vainionpää LK, Mikkonen K, Rättyä J et al. Thyroid function in girls with epilepsy with carbamazepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication. Epilepsia 2004 45:197 203.
19. Surks MI, DeFesi CR. Normal serum free thyroid hormone concentrations in patients treated with phenytoin or carbamazepine. JAMA 1996 275:1495 8.
20. Aanderud S, Myking OL, Stranjord RE. The influence of carbamazepine on thyroid hormones and thyroxine binding globulin in hypothyroid patients substituted with thyroxine. Clin Endocrinol 1981 15:247 52.
21. Aanderud S, Strandjord RE. Hypothyroidism induced by anti-epileptic therapy. Acta Neurol Scand 1980 61:330 2.
22. De Luca F, Arrigo T, Pandullo E, Siracusano MF, Benvenga S, Trimarchi F. Changes in thyroid function tests induced by 2-month carbamazepine treatment in l-thyroxine-substituted hypothyroid children. Eur J Pediatr 1986 145:77 9.
23. Simko J, Horacek J, Waberzinek G. Severe hypothyroidism as a complication of anticonvulsant treatment. Epilepsia 2004 45:292 3.
24. Wurden CJ, Levy RH. Carbamazepine: interactions with other drugs. In:Levy RH, Mattson RH, Meldrum BS, Perucca E eds. Antiepileptic drugs. Philadelphia:Lippincott Williams & Wilkins, 2002 247 61.
25. Benedetti MS, Whomsley R, Baltes E, Tonner F. Alteration of thyroid hormone homeostasis by antiepileptic drugs in humans: involvement of glucuronosyltransferase induction. Eur J Clin Pharmacol 2005 61:863 72.
26. Hegedüs L, Hansen JM, Lüdorf K, Perrild H, Feldt- Rasmussen U, Kampmann JP. Increased frequency of goitre in epileptic patients on long-term phenytoin or carbamazepine treatment. Clin Endocrinol 1985 23:423 9.
27. Roberts CGP, Ladenson PW. Hypothyroidism. Lancet 2004 363:793 803.
28. Parle JV, Franklyn JA, Cross KW, Jones SC, Sheppard MC. Prevalence and follow-up of abnormal thyrotropin (TSH) concentrations in the elderly in the United Kingdom. Clin Endocrinol 1991 34:77 83.
29. Canaris GJ, Manowitz NR, Mayor G, Ridgway C. The Colorado thyroid disease prevalence study. Arch Intern Med 2000 160:526 34.