Morphine inhibits AP-1 activity and CD14 expression in leukocytes by a nitric oxide and opioid receptor-dependent mechanism

European Journal of Anaesthesiology

Volumn 24, Issue 11, 2007, Pages 958-965

  Welters, Ingelborg D ^a   Menzebach, A ^b,c   Goumon, Y ^d   Langefeld, T W ^b   Harbach, H ^b   Muhling J ^b   Cadet, P ^e   Stefano, G B ^e  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY HOSPITAL GIESSEN   (Germany)

^c UNIVERSITY OF ROSTOCK   (Germany)

^d Centre de Neurochimie   (France)

^e STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

L selectin; Leukocytes; Lipopolysccharide; Morphine; Nitric oxide; Opioid receptors; Transcription factor AP 1

Indexed keywords

CD14 ANTIGEN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FLUORESCEIN ISOTHIOCYANATE; MORPHINE SULFATE; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; NALOXONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OPIATE; OPIATE RECEPTOR; RNA; TRANSCRIPTION FACTOR AP 1;

ANTIGEN EXPRESSION; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE; NEUTROPHIL; PHAGOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECOND MESSENGER;

ANALGESICS, OPIOID; ANTIGENS, CD14; CELL DIFFERENTIATION; CELL NUCLEUS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; INDICATORS AND REAGENTS; LEUKOCYTES; LIPOPOLYSACCHARIDES; MORPHINE; NITRIC OXIDE; PHAGOCYTES; RECEPTORS, OPIOID; RECEPTORS, OPIOID, MU; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TRANSCRIPTION FACTOR AP-1; TRETINOIN;

EID: 35148857620     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1017/S026502150700083X     Document Type: Article

References (27)

1. Welters ID, Menzebach A, Goumon Y et al. Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and μ3 opiate receptor-dependent mechanism. J Neuroimmunol 2000; 111: 139-145.
2. Stefano GB, Scharrer B, Smith EM et al. Opioid and opiate immunoregulatory processes. Crit Rev Immunol 1996; 16: 109-144.
3. Welters ID, Menzebach A, Goumon Y et al. Morphine inhibits NF-κB nuclear binding in human neutrophils and monocytes by a nitric oxide dependent mechanism. Anesthesiology 2000; 92: 1677-1684.
4. Cadet P, Mantione KJ, Stefano GB. Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene. J Immunol 2003; 170: 5118-5123.
5. Chuang TK, Killam KFJ, Chuang LF et al. Mu opioid receptor gene expression in immune cells. Biochem Biophys Res Commun 1995; 216: 922-930.
6. Magazine HI, Liu Y, Bilfinger TV, Fricchione GL, Stefano GB. Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide. J Immunol 1996; 156: 4845-4850.
7. Van Amersfoort ES, Van Berkel TJ, Kuiper J. Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. Clin Microbiol Rev 2003; 16: 379-414.
8. Triantafilou M, Triantafilou K. The dynamics of LPS recognition: complex orchestration of multiple receptors. J Endotoxin Res 2005; 11: 5-11.
9. Foletta VC, Segal DH, Cohen DR. Transcriptional regulation in the immune system: all roads lead to AP-1. J Leukoc Biol 1998; 63: 139-152.
10. Makman MH, Dobrenis K, Surratt CK. Properties of mu 3 opiate alkaloid receptors in macrophages, astrocytes, and HL-60 human promyelocytic leukemia cells. Adv Exp Med Biol 1998; 437: 137-148.
11. Foulds S. Novel flow cytometric method for quantifying nuclear binding of the transcription factor nuclear factor kappa B in unseparated human monocytes and polymorphonuclear cells. Cytometry 1997; 29: 182-186.
12. Schreiber E, Matthias P, Müller MM, Schaffner W. Rapid detection of octamer binding proteins with mini-extracts prepared from a small number of cells. Nucleic Acids Res 1989; 17: 6419.
13. Cadet P, Bilfinger TV, Fimiani C, Peter D, Stefano GB. Human vascular and cardiac endothelia express mu opiate receptor transcripts. Endothelium 2000; 7: 185-191.
14. Menzebach A, Hirsch J, Nost R, Mogk M, Hempelmann G, Welters ID. Morphine inhibits complement receptor expression, phagocytosis and oxidative burst by a nitric oxide dependent mechanism. Anasthesiol Intensivmed Notfallmed Schmerzther 2004; 39: 204-211.
15. Ocasio FM, Jiang Y, House SD, Chang SL. Chronic morphine accelerates the progression of lipopolysaccharide-induced sepsis to septic shock. J Neuroimmunol 2004; 149: 90-100.
16. Perera PY, Mayadas TN, Takeuchi O et al. CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J Immunol 2001; 166: 574-581.
17. Roy S, Chapin RB, Cain KJ, Charboneau RG, Ramakrishnan S, Barke RA. Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes. Cell Immunol 1997; 179: 1-9.
18. Adcock IM. Transcription factors as activators of gene transcription: AP-1 and NF kappa B. Monaldi Arch Chest Dis 1997; 52: 178-186.
19. Matthews JR, Botting CH, Panico M, Morris HR, Hay RT. Inhibition of NF-kappaB DNA binding by nitric oxide. Nucl Acids Res 1996; 24: 2236-2242.
20. Nikitovic D, Holmgren A, Spyrou G. Inhibition of AP-1 DNA binding by nitric oxide involving conserved cysteine residues in Jun and Fos. Biochem Biophys Res Commun 1998; 242: 109-112.
21. Beck M, Mirmohammadsadegh A, Franz B, Blanke J, Hengge UR. Opioid receptors on white blood cells: effect of HIV infection and methadone treatment. Pain 2002; 98: 187-194.
22. Kraus J, Borner C, Giannini E et al. Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site. J Biol Chem 2001; 276: 43901-43908.
23. Stefano GB, Burrill JD, Labur S, Blake J, Cadet P. Regulation of various genes in human leukocytes acutely exposed to morphine: expression microarray analysis. Med Sci Monit 2005; 11: MS35-MS42.
24. Liebermann DA, Gregory B, Hoffman B. AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int J Oncol 1998; 12: 685-700.
25. Singhal PC, Sharma P, Kapasi AA, Reddy K, Franki N, Gibbons N. Morphine enhances macrophage apoptosis. J Immunol 1998; 160: 1886-1893.
26. Suzuki S, Chuang LF, Doi RH, Chuang RY. Morphine suppresses lymphocyte apoptosis by blocking p53-mediated death signaling. Biochem Biophys Res Commun 2003; 308: 802-808.
27. Singhal PC, Reddy K, Franki N, Sanwal V, Gibbons N. Morphine induces splenocyte apoptosis and enhanced mRNA expression of cathepsin-B. Inflammation 1997; 21: 609-617.