In silico exploration of the effects of host genotype and nutrition on the genetic parameters of lambs challenged with gastrointestinal parasites

International Journal for Parasitology

Volumn 37, Issue 14, 2007, Pages 1617-1630

  Vagenas, D ^a   Doeschl Wilson, A ^a   Bishop, S C ^b   Kyriazakis, I ^a,c  

^a SCOTTISH AGRICULTURAL COLLEGE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF THESSALY   (Greece)

Author keywords

Genetic parameters; Genotype; Mathematical model; Nematodes; Nutrition; Sheep

Indexed keywords

FECUNDITY; FOOD INTAKE; GENOTYPE; GROWTH RATE; HERITABILITY; JUVENILE; LARVA; MORTALITY; NEMATODE; NUMERICAL MODEL; NUTRITION; PARASITE RESISTANCE; SHEEP;

ANIMAL MODEL; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; GENETIC CORRELATION; GENETIC PARAMETERS; GENOTYPE; HERITABILITY; INTESTINE PARASITE; LAMB; NEMATODE; NONHUMAN; NUTRITION; NUTRITIONAL ASSESSMENT; PHENOTYPE; TELADORSAGIA CIRCUMCINCTA;

ANIMAL NUTRITION PHYSIOLOGY; ANIMALS; DIET; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GROWTH; INTESTINAL DISEASES, PARASITIC; MODELS, GENETIC; NEMATODE INFECTIONS; QUANTITATIVE TRAIT, HERITABLE; SHEEP DISEASES; SHEEP, DOMESTIC;

NEMATODA; OVIS ARIES; TELADORSAGIA CIRCUMCINCTA;

EID: 35148844993     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2007.05.014     Document Type: Article

References (27)

1. Agricultural and Food Research Council, 1993. Energy and Protein Requirements of Ruminants. An advisory manual prepared by AFRC Technical Committee on Responses to Nutrients. CAB International, Wallingford, UK.
2. Baker R.L., Nagda S., Rodriguez-Zas S.L., Southey B.R., Audho J.O., Aduda E.O., and Thorpe W. Resistance and resilience to gastro-intestinal nematode parasites and relationships with productivity of Red Maasai, Dorper and Red Maasai × Dorper crossbred lambs in the sub-humid tropics. Anim. Sci. 76 (2003) 119-136
3. Bishop S.C., and Stear M.J. Modelling responses to selection for resistance to gastro-intestinal parasites in sheep. Anim. Sci. 64 (1997) 469-478
4. Bishop S.C., and Stear M.J. Genetic and epidemiological relationships between productivity and disease resistance: gastro-intestinal parasite infection in growing lambs. Anim. Sci. 69 (1999) 515-524
5. Bishop S.C., Bairden K., McKellar Q.A., Park M., and Stear M.J. Genetic parameters for faecal egg count following mixed, natural, predominantly Ostertagia circumcincta infection and relationships with live weight in young lambs. Anim. Sci. 63 (1996) 423
6. Bishop S.C., Jackson F., Coop R.L., and Stear M.J. Genetic parameters for resistance to nematode infections in Texel lambs. Anim. Sci. 78 (2004) 185-194
7. Bisset S.A., Vlassoff P.G.C., Douch W.E., Jonas W.E., West C.J., and Green R.S. Nematode burdens and immunological responses following natural challenge in Romney lambs selectively bred for low or high faecal worm egg count. Vet. Parasitol. 61 (1996) 249-263
8. Blaxter K.L., Fowler V.R., and Gill J.C. A study of the growth of sheep to maturity. J. Agric. Sci. 98 (1982) 405-420
9. Coop R.L., and Kyriazakis I. Nutrition-parasite interaction. Vet. Parasitol. 84 (1999) 187-204
10. Coop R.L., Sykes A.R., and Angus K.W. Effect of a daily intake of Ostertagia circumcincta larvae on body-weight, food-intake and concentration of serum constituents in sheep. Res. Vet. Sci. 23 (1977) 76-83
11. Coop R.L., Sykes A.R., and Angus K.W. The effect of three levels of Ostertagia circumcincta larvae on growth rate, food intake and body composition of growing lambs. J. Agric. Sci. 98 (1982) 247-255
12. Davies G., Stear M.J., and Bishop S.C. Genetic relationships between indicator traits and nematode parasite infection levels in 6-month-old lambs. Anim. Sci. 80 (2005) 143-150
13. Emmans G.C. Effective energy - a concept of energy-utilization applied across species. Br. J. Nutr. 71 (1994) 801-821
14. Falconer D.S., and Mackay T.F.C. Introduction to Quantitative Genetics (1997), Longman, Harlow, Essex
15. Friggens N.C., Shanks M., Kyriazakis I., Oldham J.D., and McClelland T.H. The growth and development of nine European sheep breeds. 1. British breeds: Scottish blackface, Welsh Mountain and Shetland. Anim. Sci. 65 (1997) 409-426
16. Gauly M., Kraus M., Vervelde L., van Leeuwen M.A.W., and Erhardt G. Estimating genetic differences in natural resistance in Rhön and Merinoland sheep following experimental Haemonchus contortus infection. Vet. Parasitol. 106 (2002) 55-67
17. Jackson F., and Coop R.L. The development of anthelmintic resistance in sheep nematodes. Parasitology 120 (2000) S95-S107
18. Knap P.W., and Schrama J.W. Simulation of growth in pigs: approximation of protein turnover parameters. Anim. Sci. 63 (1996) 533-547
19. McEwan J.C., Mason P., Baker R.L., Clarke J.N., Hickey S.M., and Turner K. Effect of selection for productivity traits on internal parasite resistance in sheep. Proc. New Zeal. Soc. An. 52 (1992) 53-56
20. McEwan J.C., Dodds K.G., Greer G.J., Bain W.E., Duncan S.J., Wheeler R., Knowler K.J., Reid P.J., Green R.S., and Douch P.G.C. Genetic estimates for parasite resistance traits in sheep and their correlations with production traits. New Zeal. J. Zool. 22 (1995) 177
21. Morris C.A., Wheeler M., Watson T.G., Hosking B.C., and Leathwick D.M. Direct and correlated responses to selection for high or low faecal nematode egg count in Perendale sheep. New Zeal. J. Agric. Res. 48 (2005) 1-10
22. Nieuwhof G.J., and Bishop S.C. Costs of the major endemic diseases of sheep in Great Britain and the potential benefits of reduction in disease impact. Anim. Sci. 81 (2005) 23-29
23. Stear M.J., Bairden K., Duncan J.L., Holmes P.H., McKellar Q.A., Park M., Strain S., Murray M., Bishop S.C., and Gettinby G. How hosts control worms. Nature 389 (1997) 27
24. Vagenas, D., Bishop, S.C., Kyriazakis, I., in press-a. A model to account for the consequences of host nutrition on the outcome of gastrointestinal parasitism in sheep: logic and concepts. Parasitology, doi:10.1017/S00311820007002570.
25. Vagenas, D., Bishop, S.C., Kyriazakis, I., in press-b. A model to account for the consequences of host nutrition on the outcome of gastrointestinal parasitism in sheep: model evaluation. Parasitology, doi:10.1017/S00311820007002624.
26. Vagenas, D., White, I.M.S., Stear, M.J., Bishop, S.C., in press-c. Estimation of heritabilities and correlations between repeated faecal egg count measurements in lambs facing natural nematode parasite challenge, using a random regression model. J. Agric. Sci., doi:10.1017/S0021859607007137.
27. Waller P.J. Nematode parasite control of livestock in the tropics/subtropics: the need for novel approaches. Int. J. Parasitol. 27 (1997) 1193-1201