In vivo immunostaining demonstrates macrophages associate with growing and regressing vessels

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 9, 2007, Pages 4335-4341

  Shen, Jikui ^a   Xie, Bing ^a   Dong, Aling ^a   Swaim, Mara ^a   Hackett, Sean F ^a   Campochiaro, Peter A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD31 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; FLUORESCEIN ISOTHIOCYANATE; PLACENTAL GROWTH FACTOR; CXCR4 PROTEIN, MOUSE; DIFFERENTIATION ANTIGEN; MONOCYTE MACROPHAGE DIFFERENTIATION ANTIGEN; MONOCYTE-MACROPHAGE DIFFERENTIATION ANTIGEN; PLACENTA PROTEIN; PRODUCT PLACENTA GROWTH FACTOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INCUBATION TIME; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RETINA BLOOD VESSEL; RETINA ISCHEMIA; RETINA NEOVASCULARIZATION; RETINOPATHY; ANIMAL; C57BL MOUSE; CHEMISTRY; DISEASE MODEL; FLUORESCENCE MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; METABOLISM; METHODOLOGY; NEWBORN; PATHOLOGY; REPERFUSION INJURY;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD31; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION; DISEASE MODELS, ANIMAL; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; PREGNANCY PROTEINS; RECEPTORS, CXCR4; REPERFUSION INJURY; RETINAL NEOVASCULARIZATION; RETINAL VESSELS;

EID: 35148832049     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.07-0113     Document Type: Article

References (40)

1. Campochiaro PA. Molecular targets for retinal vascular diseases. J Cell Physiol. 2007;210:575-581.
2. Baatz H, Pleyer Y, Thiel HJ, Hammer C. In vivo study of leukocyte - endothelium interaction in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci. 1995;36:1960-1967.
3. Becker MD, Nobiling R, Planck SR, Rosenbaum JT. Digital video-imaging of leukocyte migration in the iris: intravital microscopy in a physiological model during the onset of endotoxin-induced uveitis. J Immunol Methods. 2000;240:23-37.
4. Smith JR, O'Rourke LM, Becker MD, et al. Anti-rat ICAM-1 antibody does not influence the course of experimental melanin-induced uveitis. Curr Eye Res. 2000;5:906-912.
5. Yang P, Smith JR, Damodar KS, Planck SR, Rosenbaum JT. Visualization of cell death in vivo during murine endotoxin-induced uveitis. Invest Ophthalmol Vis Sci. 2003;44:1993-1997.
6. Becker MD, Planck SR, Crespo S, et al. Immunohistology of antigen-presenting cells in vivo: a novel method for serial observation of fluorescently labeled cells. Invest Ophthalmol Vis Sci. 2003;44:2004-2009.
7. Miyamoto K, Hiroshiba N, Tsujikawa A, Ogura Y. In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci. 1998;39:2190-2194.
8. Miyamoto K, Khosrof S, Bursell S-E, et al. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci USA. 1999;96:10836-10841.
9. Choi SS, Doble N, Hardy JL, et al. In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function. Invest Ophthalmol Vis Sci. 2006;47:2080-2092.
10. Wolfing JL, Chung M, Carroll J, Roorda A, Williams DR. High-resolution retinal imaging of cone-rod dystrophy. Ophthalmology. 2006;113:1011-1019.
11. Garcia de la Cera E, Rodriguez G, Llorente L, Schaeffel F, Marcos S. Optical aberrations in the mouse eye. Vision Res. 2006;46:2546-2553.
12. Mori K, Duh E, Gehlbach P, et al. Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. J Cell Physiol. 2001;188:253-263.
13. Park JE, Chen HH, Winer J, Houck KA, Ferrara N. Placenta growth factor: potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding Flt-1 but not to Flk-1/KDR. J Biol Chem. 1994;269:25646-25654.
14. Barleon B, Sozzani S, Zhou D, Weich HA, Mantovani A, Marme D. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood. 1996;87:3336-3343.
15. Clauss M, Weich H, Breier G, et al. The vascular endothelial growth factor receptor Flt-1 mediates biological activities: implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem. 1996;271:17629-17634.
16. Klein R. Retinopathy in a population-based study. Trans Am Ophthalmol Soc. 1992;90:561-594.
17. Ozaki H, Yu A, Della N, et al. Hypoxia inducible factor-1a is increased in ischemic retina: temporal and spatial correlation with VEGF expression. Invest Ophthalmol Vis Sci. 1999;40:182-189.
18. Kelly BD, Hackett SF, Hirota K, et al. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res. 2003;93:1074-1081.
19. Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LEH. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci USA. 1995;92:905-909.
20. Aiello LP, Pierce EA, Foley ED, et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci USA. 1995;92:10457-10461.
21. Robinson GS, Pierce EA, Rook SL, Foley E, Webb R, Smith LES. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc Natl Acad Sci USA. 1996;93:4851-4856.
22. Ozaki H, Seo M-S, Ozaki K, et al. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am J Pathol. 2000;156:679-707.
23. Oshima Y, Deering T, Oshima S, et al. Angiopoietin-2 enhances retinal vessel sensitivity to vascular endothelial growth factor. J Cell Physiol. 2004;199:412-417.
24. Oshima Y, Oshima S, Nambu H, et al. Different effects of angiopoietin 2 in different vascular beds in the eye; new vessels are most sensitive. FASEB J. 2005;19:963-965.
25. Hammes H, Brownlee M, Jonczyk A, Sutter A, Preissner K. Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization. Nat Med. 1996;2:529-533.
26. Luna J, Tobe T, Mousa SA, Reilly TM, Campochiaro PA. Antagonists of integrin alpha-v beta-3 inhibit retinal neovascularization in a murine model. Lab Invest. 1996;75:563-573.
27. Ando A, Mori K, Yamada H, et al. Nitric oxide is proangiogenic in retina and choroid. J Cell Physiol. 2002;191:116-124.
28. Barreiro RA, Schadlu R, Herndon J, Kaplan HJ, Ferguson TA. The role of Fas-FasL in the development and treatment of ischemic retinopathy. Invest Ophthalmol Vis Sci. 2003;44:1282-1286.
29. Al-Shabrawey M, Bartoli M, El-Remessy AB, et al. Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy. Am J Pathol. 2005;167:599-607.
30. Chan CK, Pham LN, Zhou J, Spee C, Ryan SJ, Hinton DR. Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization. Lab Invest. 2005;85:721-733.
31. Gerhardt H, Golding M, Fruttiger M, et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol. 2003;161:1163-1177.
32. Grant MB, May WS, Caballero S, et al. Adult hematopoietic stem cells provide functional hemangioblastic activity during retinal neovascularization. Nat Med. 2002;8:607-612.
33. Joussen AM, Poulaki V, Le ML, et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004;18:1450-1452.
34. Killingsworth MC, Sarks JP, Sarks SH. Macrophages related to Bruch's membrane in age-related macular degeneration. Eye. 1990;4:613-621.
35. Tsutsumi C, Sonoda KH, Egashira K, et al. The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization. J Leukoc Biol. 2003;74:25-32.
36. Lang RA, Bishop MJ. Macrophages are required for cell death and tissue remodeling in the developing mouse eye. Cell. 1993;74:453-462.
37. Lobov IB, Rao S, Carroll TJ, et al. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature. 2005;437:417-421.
38. Duffield JS, Forbes SJ, Consandinou CM, et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest. 2005;115:56-65.
39. Plate KH, Breier G, Millauar B, Ullrich A, Risau W. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res. 1993;53:5822-5827.
40. 121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors. Proc Natl Acad Sci USA. 2002;99:7866-7871.