Polyethylene glycol conjugated bovine hemoglobin containing 15% MetHb plays approving effect in exchange transfusion rabbit model

Artificial Cells, Blood Substitutes, and Biotechnology

Volumn 35, Issue 5, 2007, Pages 490-506

  He, Xue Ying ^a   Guan, Bo ^a   Zhang, Xiao Wei ^a   Xu, Ke ^a   Yu, Yong Hai ^a   Liu, Qian ^a   Bai, Jian Shi ^b  

^a Beijing Kaizheng Biotech Dev Ltd   (China)

^b NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

Author keywords

Exchange transfusion; Methemoglobin; PEG hemoglobin; Polyethylene glycol; Resuscitation

Indexed keywords

CONJUGATED POLYMERS; MAMMALS; PROTEINS; RESUSCITATION;

EXCHANGE TRANSFUSION; METHEMOGLOBIN; PEG-HEMOGLOBIN;

POLYETHYLENE GLYCOLS;

HEMOGLOBIN; MACROGOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD AUTOTRANSFUSION; BLOOD CHEMISTRY; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; ELECTRON MICROSCOPY; EXCHANGE BLOOD TRANSFUSION; HISTOLOGY; KIDNEY; KIDNEY TUBULE EPITHELIUM; LIVER; LIVER CELL; MALE; NONHUMAN; RABBIT; RESUSCITATION;

ANIMALS; BLOOD SUBSTITUTES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCHANGE TRANSFUSION, WHOLE BLOOD; HEMOGLOBINS; HEPATOCYTES; LIVER; MALE; METHEMOGLOBIN; POLYETHYLENE GLYCOLS; RABBITS; RESUSCITATION;

BOVINAE; ORYCTOLAGUS CUNICULUS;

EID: 35148825097     PISSN: 10731199     EISSN: 15324184     Source Type: Journal    
DOI: 10.1080/10731190701378550     Document Type: Article

References (16)

1. Bi, Z.G., He, X.Y., Zhang, X.W., Liu, Q. (1983). Pharmacodynamic study of polyethylene glycol conjugated bovine hemoglobin (PEG-bHb) in rats. Artif. Cells Blood Substit. Immobil. Biotechnol. 32(2): 173-187.
2. Muller, M., Dumdey, R., Rapoport, S. (1983). Superoxide radicals in the metabolism of the red cell. Biomed. Biochim. Acta. 42(11-12): S297-S301.
3. Isselbacher, K.J., Adams, R.A., Braunwald, E., Petersdorf, R.G., Wilson, J.D., eds. (1980). Harrison's Principles of Internal Medicine, 9th ed. New York: McGraw Hill.
4. Linberg, R., Conover, C.D., Shum, K.L., Shorr, R.G.L. (1998). Hemoglobin based oxygen carriers: How much methemoglobin is too much? Artif. Cells, Blood Subs. and Immob. Biotech. 26(2): 133-148.
5. Snyder, S.R., Walder, J.A. (1991). Chemically modified and recombinant hemoglobin blood substitutes. Biotechnology 19: 101-116.
6. Moore, G.L., Zegna, A., Ledford, M.E., Huoing, J.P., Fishman, R.M. (1992). Evaluation of methemoglobin formation during the storage of various hemoglobin solutions. Artif. Organs. 16: 513-518.
7. Carmichael, F.J., Ali, A.C., Campbell, J.A., Langlois, S.F., Biro, G.P., Willan, A.R., Pierce, C.H., Greenburg, A.G. (2000). A phase I study of oxidized raffinose cross-linked human hemoglobin. Crit. Care Med. 28: 2283-2292.
8. Hughes, G.S. Jr., Francome, S.F., Antal, E.J., Adams, W.J., Locker, P.K., Yancey, E.P., Jacobs, E.E. Jr. (1995). Hematologic effects of a novel hemoglobin-based oxygen carrier in normal male and female subjects. J. Lab Clin. Med. 126: 444-451.
9. Kang, G.F. (1991). Clinical Biochemistry. Beijing: People's Medical Publishing House (in Chinese) (pp. 247-249).
10. Ketcham, E.M., Cairns, C.B. (1999). Hemoglobin-based oxygen carriers: Development and clinical potential. Annals of Emergency Medicine 33: 326-337.
11. Den Boer, P.J., Bleeker, W.K., Rigter, G., Agterberg, P., Stekkinger, P., Kannegieter, E.M., Bakker, J.C. (1992). Intravascular reduction of methemoglobin in plasma of the rat in vivo. Biomat. Artif. Blood Immobil. Biotech. 20: 647-650.
12. Dorman, S.C., Kenny, C.F., Miller, L., Hirsch, R.E., Harrington, J.P. (2002). Role of redox potential of hemoglobin-based oxygen carriers on methemoglobin reduction by plasma components. Artif. Cells Blood Substit. Immobil. Biotechnol. 30: 39-51.
13. Faivre, B., Menu, P., Labrude, P., Grandgeorge, M., Vigneron, C. (1994). Methemoglobin formation after administration of hemoglobin conjugated to carboxylate dextran in guinea pigs. Attempts to prevent the oxidation of hemoglobin. Artif. Cells Blood Substit. Immobil. Biotechnol. 22: 551-558.
14. Rubin, E., Farber, J.L. (with 39 contributors) (1998). Pathology, 2nd ed. Philadelphia: Lippincott (pp. 3-5).
15. Dong, J. (1996). Pathology. 2nd ed. Beijing: People's Medical Publishing House (in Chinese) (pp. 30-32).
16. Conover, C.D., Linberg, R., Gilbert, C.W., Shum, K.L., Shorr, R.G.L. (1997). Effect of polyethylene glycol conjugated bovine hemoglobin in both top-load and exchange transfusion rat models. Artif. Organs 21: 1066-1075.