Lamotrigine in idiopathic epilepsy - Increased risk of cardiac death

Acta Neurologica Scandinavica

Volumn 116, Issue 5, 2007, Pages 345-

  VanLandingham, Kevan E ^a   Dixon, Ruth M ^b  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LAMOTRIGINE;

CARDIOVASCULAR RISK; DRUG FATALITY; DRUG SAFETY; EPILEPSY; HEART ARRHYTHMIA; HUMAN; IDIOPATHIC DISEASE; LETTER; MONOTHERAPY; OUTCOME ASSESSMENT; RISK ASSESSMENT; SUDDEN DEATH; TREATMENT RESPONSE;

ADOLESCENT; ADULT; ANTICONVULSANTS; ARRHYTHMIAS, CARDIAC; DEATH, SUDDEN, CARDIAC; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; FEMALE; HEART CONDUCTION SYSTEM; HUMANS; RISK FACTORS; SEX FACTORS; SODIUM CHANNELS; TRIAZINES;

EID: 35148824658     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2007.00903.x     Document Type: Letter

References (5)

1. Aurlien D, Tauboll E, Gjerstad L. Lamotrigine in idiopathic epilepsy - increased risk of cardiac death. Acta Neurol Scand 2007 115:199 203.
2. Danielsson BR, Lansdell K, Patmore L, Tomson T. Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents. Epilepsy Res 2005 63:17 25.
3. Online at: http://ctr.gsk.co.uk/Summary/lamotrigine/studylist.asp and select study SCA104648, accessed on 24 April 2007.
4. Leestma JE, Walczak T, Hughes JR, Kalekar MB, Teas SS. A prospective study on sudden unexpected death in epilepsy. Ann Neurol 1989 26:195 203.
5. Walczak TS, Leppik IE, D'Amelio M et al. Incidence and risk factors in sudden unexpected death in epilepsy: a prospective cohort study. Neurology 2001 56:519 25.