Additive action of vitamin C and E against norgestrel induced genotoxicity

Biomedical Research

Volumn 18, Issue 3, 2007, Pages 155-160

  Siddique, Yasir Hasan ^a   Ara, Gulshan ^a   Beg, Tanveer ^a   Afzal, Mohammad ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

Antioxidants; Chromosomal aberrations; Genotoxicity; Norgestrel; Sister chromatid exchanges

Indexed keywords

ALPHA TOCOPHEROL; ANTIFUNGAL AGENT; ASCORBIC ACID; COLCHICINE; CYCLOPHOSPHAMIDE; NORGESTREL;

ADULT; ARTICLE; CHROMOSOME ABERRATION; DRUG EFFECT; DRUG POTENTIATION; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE; METAPHASE; SISTER CHROMATID EXCHANGE;

EID: 35148822371     PISSN: 0970938X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Yamamoto KR. Steroid receptor regulated transcription of specific genes and gene networks. Annual Rev Genet 1985; 19: 209-225.
2. Biri A, Civelek E, Karahalil B, Sardar S. Assessment of DNA damage in women using oral contraceptives. Mutat Res 2002; 521: 113-119.
3. Siddique YH, Beg T, Afzal M. Protective effect of nordihydroguaiaretic acid (NDGA) against norgestrel induced genotoxic damage. Toxicol in vitro 2006; 20: 227-233.
4. Carr DH. Chromosomes after oral contraceptives. Lancet 1967; 2: 830.
5. Murthy PBK, Prema K. Sister chromatid exchanges in oral contraceptive users. Mutat Res 1979; 68: 149-152.
6. Koul A, Khandeia KL, Koul IB, Gupta MP, Mazid S, Sharma RR. Effect of ascorbic acid on antioxidant defense systems and lipid peroxidation in guinea pigs. J Clinical Biochem Nutr 1989; 6: 21-27.
7. Sram RJ, Dobias J, Pasterkova A, Rossner P, Joner L. Effect of ascorbic acid prophylaxis on the frequency of chromosome aberration in peripheral lymphocytes of coal tar workers. Mutat Res 1983; 120: 181-186.
8. Krishna G, Nath J. Inhibition of cyclophosphamide, Mitomycin induced sister chromatid exchange in mice by vitamin C. Cancer Res 1986; 46: 2670-2674.
9. Aly FAE, Donya SM. In vivo antimutagenic effect of vitamins C and E against rifampicin-induced chromosome aberrations in mouse bone marrow cells. Mutat Res 2002; 518: 1-7.
10. Siddique YH, Afzal M. Protective role of allicin and L-ascorbic acid against the genotoxic damage induced by Chlormadinone acetate in cultured human lymphocytes. Indian J Exp Biol 2005; 43: 769-772.
11. Ahmad S, Hoda A, Afzal M. Additive action of vitamin C and E against hydrocortisone induced genotoxicity in human lymphocyte chromosome. Int J Vitam Nutr 2002; 72: 204-209.
12. Siddique YH, Beg T, Afzal M. Antigenotoxic effects of ascorbic acid against megestrol acetate induced genotoxicity in mice. Hum Exp Toxicol 2005; 24: 121-127.
13. Siddique YH, Ara G, Beg T, Afzal M. Protective role of natural plant products against estradiol-17β induced genotoxic damage. Recent Prog Med Plants 2005; 15: 415-429.
14. Siddique YH, Afzal M. Antigenotoxic effect of nordihydroguaiaretic acid (NDGA) against SCEs induced by estradiol-17β in human lymphocyte chromosomes in vitro. Indian Biol 2004; 36: 25-27.
15. Ahmad MS, Sheeba, Afzal M. Amelioration of genotoxic damage by certain phytoproducts in human lymphocytes cultures. Chem Biol Interact 2004; 150: 107-115.
16. Carballo MA, Alvarez S, Boveris A. Cellular stress by light and Rose Bengal in human lymphocytes. Mutat Res 1993; 288: 215-222.
17. Maron DM, Ames BN. Revised methods for the Salmonella mutagenicity test. Mutat Res 1983; 113: 173-215.
18. IPCS, International Program on Chemical Safety. Environmental Health Criteria 46, Guidelines for the study of Genetic Effects in Human Populations, 1965; Vol. 46. WHO, Geneva, pp. 25-54.
19. Perry P, Wolff S. New Giemsa method for the differential staining of sister chromatids. Nature 1974; 251: 156-158.
20. Siddique YH, Afzal M. Genotoxic potential of cyproterone acetate: a possible role of reactive oxygen species. Toxicol in vitro 2005; 19: 63-68.
21. Siddique YH, Afzal M. Induction of chromosomal aberrations and sister chromatid exchange by chlormadinone acetate: a possible role of reactive oxygen species. Indian J Exp Biol 2004; 42: 1078-1083.
22. Siddique YH, Afzal M. In vivo evaluation of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) by lynestrenol. Indian J Exp Biol 2005; 42: 291-293.
23. Siddique YH, Afzal M. Evaluation of genotoxic potential of ethynodioldiacetate in human lymphocytes in vitro. Curr Sci 2004; 86: 1161-1165.
24. Siddique YH, Afzal M. Evaluation of genotoxic potential of norethynodrel in human lymphocytes in vitro. J Environ Biol 2005; 26 (2 suppl.) 367-392.
25. Siddique YH, Beg T, Afzal M. Genotoxic potential of ethinylestradiol in cultured mammalian cells. Chem Biol Interact 2005; 151: 133-141.
26. Fishman J. Aromatic hydroxylation of estrogens. Ann Rev Physiol 1983; 45, 61-72.
27. Bolton JL, Pisha E, Zhang F, Qiu S. Role of quinoids in estrogens carcinogenesis. Chem Res Toxicol 1998; 11: 1113-1127.
28. Edgar JA. Ascorbic acid and biological alkylating agents. Nature 1974; 248: 136-137.
29. Bielski BHJ, Allen O, Schwarz HA. Mechanism of disproportionation of ascorbic radicals. J Am Chem Soc 1981; 103: 3516.
30. Bendich A. Antioxidant Micronutrients and Immune Responses, "Micronutrients and Immune Functions." In: Bendich, A., Chandra, R.K. (Eds.) New York Academy of Sciences, New York, 1991; pp. 175.
31. Islam S, Safiullah, Ahmad M. Mutagenic activity of certain synthetic steroids: Structural requirement for mutagenic activity in Salmonella and E. coli. Mutat Res 1991; 259: 177-87.