The mechanism of transduction of mechanical strains into biological signals at the bone cellular level

European Journal of Histochemistry

Volumn 51, Issue SUPPL.1, 2007, Pages 15-20

  Marotti, Gastone ^a   Palumbo, C ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Cytokines; Mechanical strains; Osteoclasts; Osteogenic cells

Indexed keywords

ANIMAL; BONE; CONNECTIVE TISSUE; CYTOLOGY; HUMAN; MECHANICAL STRESS; OSTEOCYTE; PHYSIOLOGY; REVIEW;

ANIMALS; BONE AND BONES; CONNECTIVE TISSUE; HUMANS; OSTEOCYTES; STRESS, MECHANICAL;

EID: 35148815359     PISSN: 1121760X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (25)

1. Ardizzoni A, Muglia MA, Marotti G. Osteocyte size-lamellar thickness relationships. 8th Congress of ISBM, J Bone Miner Res 1999.
2. Bagi CM, Miller SC. Comparison of osteopenic changes in cancellous bone induced by ovariectomy and/or immobilization in adult rats. Anat Rec 1994; 239:243-54.
3. Frost H.M. Bone "mass" and the "mechanostat": A proposal. Anat Rec 1987; 219:1-9.
4. Frost HM. Introduction to a new skeletal physiology. Vols I, II. Pajaro Group, Pueblo, CO, 1995.
5. Hofbauer LC, Kuhne CA, Viereck V. The OPG/RANKL/RANK system in metabolic bone diseases. J Musculoskel Neuron Interact 2004; 4:268-75.
6. Lozupone E, Favia A. Density of trabecular framework and osteogenic activity in the spongiosa of long bones subjected to drastic changes in mechanical loading. Anat Anz 1982; 152:245-61.
7. Lozupone E, Favia A. Distribution of resorption processes in the compacta and spongiosa of bones from lactating rats fed a low-calcium diet. Bone 1988; 9:215-24.
8. Manson JD, Waters NE. Maturation rate of osteon of the cat. Nature, Lond 1963; 200:89-490.
9. Marotti G. Decrement in volume of osteoblasts during osteon formation and its effect on the size of the corresponding osteocytes. In: "Bone histomorphometry" Meunier P. J ed.; Armour Montagu, Levallois, 1976, pp. 385-97.
10. Marotti G. The structure of bone tissues and the cellular control of their deposition. Italian J Anat Embryol 1996; 101:25-79.
11. Marotti G, Camosso ME. Quantitative analysis of osteonic bone dynamics in the various periods of life. In "LesTissus Calcifiés", eds. Milhaud G, Owen M, Blackwood HJJ, SEDES, Paris, 1968, pp. 423-7.
12. Marotti G, Ferretti M, Muglia MA, Palumbo C, Palazzini S. A quantitative evaluation of osteoblast-osteocyte relationships on growing endosteal surface of rabbit tibiae. Bone 1992; 13:363-8.
13. Marotti G, Palazzini S, Palumbo C. Evidence of a twofold regulation of osteoblast activity: "Volume transmission" and "Wiring transmission". Calcif Tissue Int 1993; 53:440.
14. Marotti G, Palazzini S, Palumbo C, Ferretti M. Ultrastructural evidence of the existence of a dendritic network throughout the cells of the osteogenic lineage: the novel concept of wiring-and volumetransmission in bone. Bone 1996; 19(Suppl. 3):151S.
15. Marotti G, Remaggi F, Zaffe D. Quantitative investigation on osteocyte canaliculi in human compact and spongy bone. Bone 1985; 6:335-7.
16. Martin TJ. Parine regulation of osteoclast formation and activity: Milestones in discovery. J Musculoskel Neuron Interact 2004; 4:243-53.
17. Palazzini S, Palumbo C, Ferretti M. Marotti G. Stromal cell structure and relationships in perimedullary spaces of chick embryo shaft bones. Anat Embryol 1998; 197:349-57.
18. Palumbo C. A three-dimensional ultrastructural study of osteoid-osteocytes in the tibia of chick embryos. Cell Tissue Res 1986; 246:125-31.
19. Palumbo C, Ferretti M, Ardizzoni A, Zaffe D, Marotti G. Osteocyteosteoclast morphological relationships and the putative role of osteocytes in bone remodeling. J Musculoskel Neuron Interact 2001; 1:327-32.
20. Palumbo C, Palazzini S, Marotti G. Morphological study of intercellular junctions during osteocyte differentiation. Bone 11; 1990a:401-6.
21. Palumbo C, Palazzini S, Zaffe D, Marotti G. Osteocyte differentiation in the tibia of newborn rabbit: an ultrastructural study of the formation of cytoplasmic processes. Acta Anat 1990b; 137:350-8.
22. Rubinacci A, Covini M, Bisogni C, Villa I, Galli M, Palumbo C, et al. Bone as an ion exchange system: evidence for a limk between mechanotransduction and metabolic needs. Am J Physiol Endocrinl Metab 2002; 282:E851-64.
23. Rubinacci A, Villa I, Dondi Benelli F, Borgo E, Ferretti M, Palumbo C, et al. Osteocyte-bone lining cell system at the origin of steady ionic current in amphibian bone. Calc Tissue Int 1998; 63:331-9.
24. SkerryTM. Signalling pathways activated during functional adaptation of the skeleton to mechanical loading suggest a role for excitatory amino acid glutamate. 1st International Workshop on Musculoskeletal Interactions, Santorini Greece, I.S.M.N.I., 1999, p. 20.
25. Zaman G, Pitsillides AA, Rawlinson SCF, Suswillo RFL, Mosley JR, Cheng MZ, et al. Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes J Bone Miner Res 1999; 14:1123-31.