The high incidence of the emergence of entecavir-resistant mutants among patients infected with lamivudine-resistant hepatitis B virus

Tohoku Journal of Experimental Medicine

Volumn 213, Issue 2, 2007, Pages 181-186

  Nagasaki, Futoshi ^a   Nitsuma, Hirofumi ^a   Ueno, Yoshiyuki ^a   Inoue, Jun ^a   Kogure, Takayuki ^a   Fukushima, Koji ^a   Shimosegawa, Tooru ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Antiviral resistant virus; Entecavir; HBV; Lamivudine

Indexed keywords

ADEFOVIR; ALANINE AMINOTRANSFERASE; ENTECAVIR; LAMIVUDINE; VIRUS DNA;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; CASE REPORT; DRUG EFFICACY; FEMALE; FOLLOW UP; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; INCIDENCE; JAPAN; MALE; NONHUMAN; VIRUS LOAD; VIRUS MUTANT; VIRUS MUTATION;

ADULT; ANTIVIRAL AGENTS; DRUG RESISTANCE, VIRAL; FEMALE; GUANINE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INCIDENCE; LAMIVUDINE; MALE; MIDDLE AGED; MUTATION; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 35048904475     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.213.181     Document Type: Article

References (27)

1. Arauz-Ruiz, P., Norder, H., Robertson, B.H. & Magnius, L.O. (2002) Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J. Gen. Virol., 83, 2059-2073.
2. Dienstag, J.L., Schiff, E.R., Wright, T.L., Perrillo, R.P., Hann, H.W., Goodman, Z., Crowther, L., Condreay, L.D., Woessner, M., Rubin, M. & Brown, N.A. (1999) Lamivudine as initial treatment for chronic hepatitis B in the United States. N. Engl. J. Med., 341, 1256-1263.
3. Fung, S.K., Andreone, P., Han, S.H., Rajender Reddy, K., Regev, A., Keeffe, E.B., Hussain, M., Cursaro, C., Richtmyer, P., Marrero, J.A. & Lok, A.S. (2005) Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation. J. Hepatol., 43, 937-943.
4. Honkoop, P., de Man, R.A., Niesters, H.G., Zondervan, P.E. & Schalm, S.W. (2000) Acute exacerbation of chronic hepatitis B virus infection after withdrawal of lamivudine therapy. Hepatology, 32, 635-639.
5. Kapoor, D., Guptan, R.C., Wakil, S.M., Kazim, S.N., Kaul, R., Agarwal, S.R., Raisuddin, S., Hasnain, S.E. & Sarin, S.K. (2000) Beneficial effects of lamivudine in hepatitis B virus-related decompensated cirrhosis. J. Hepatol., 33, 308-312.
6. Kikuchi, K., N.H., Ishii, M., Julieta, G.C., Shang, H. & Ojima, T. (2000) Genoepidemiology and its relationship to clinical features in patients infected chronically with hepatitis B virus (HBV). Hepatology Res., 17, 43-55.
7. Lee, W.M. (1997) Hepatitis B virus infection. N. Engl. J. Med., 337, 1733-1745.
8. Liaw, Y.F., Leung, N.W., Chang, T.T., Guan, R., Tai, D.I., Ng, K.Y., Chien, R.N., Dent, J., Roman, L., Edmundson, S. & Lai, C.L. (2000) Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. Gastroenterology, 119, 172-180.
9. Lok, A.S. & McMahon, B.J. (2001) Chronic hepatitis B. Hepatology, 34, 1225-1241.
10. Lok, A.S. & McMahon, B.J. (2007) Chronic hepatitis B. Hepatology, 45, 507-539.
11. Maddrey, W.C. (2000) Hepatitis B: an important public health issue. J. Med. Virol., 61, 362-366.
12. Nagasaki, F., Niitsuma, H., Cervantes, J.G., Chiba, M., Hong, S., Ojima, T., Ueno, Y., Bondoc, E., Kobayashi, K., Ishii, M. & Shimosegawa, T. (2006a) Analysis of the entire nucleotide sequence of hepatitis B virus genotype B in the Philippines reveals a new subgenotype of genotype B. J. Gen. Virol., 87, 1175-1180.
13. Nagasaki, F., Ueno, Y., Yamamoto, T., Nakagomi, Y., Kido, O., Kakazu, E., Matsuda, Y., Kogure, T., Yamagiwa, Y., Kikuchi, K., Fukushima, K., Kanno, N., Niitsuma, H. & Shimosegawa, T. (2006b) Sustained clinical improvement of a patient with decompensated hepatitis B virus-related cirrhosis after treatment with lamivudine monotherapy. Tohoku J. Exp. Med., 210, 29-36.
14. Norder, H., Hammas, B., Lofdahl, S., Courouce, A.M. & Magnius, L.O. (1992) Comparison of the amino acid sequences of nine different serotypes of hepatitis B surface antigen and genomic classification of the corresponding hepatitis B virus strains. J. Gen. Virol., 73, 1201-1208.
15. Norder, H., Courouce, A.M., Coursaget, P., Echevarria, J.M., Lee, S.D., Mushahwar, I.K., Robertson, B.H., Locarnini, S. & Magnius, L.O. (2004) Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes, and HBsAg subtypes. Intervirology, 47, 289-309.
16. Okamoto, H., Imai, M., Tsuda, F., Tanaka, T., Miyakawa, Y. & Mayumi, M. (1987) Point mutation in the S gene of hepatitis B virus for a d/y or w/r subtypic change in two blood donors carrying a surface antigen of compound subtype adyr or adwr. J. Virol., 61, 3030-3034.
17. Okamoto, H., Tsuda, F., Sakugawa, H., Sastrosoewignjo, R.I., Imai, M., Miyakawa, Y. & Mayumi, M. (1988) Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J. Gen. Virol., 69, 2575-2583.
18. Orito, E., Mizokami, M., Sakugawa, H., Michitaka, K., Ishikawa, K., Ichida, T., Okanoue, T., Yotsuyanagi, H. & Iino, S. (2001) A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group. Hepatology, 33, 218-223.
19. Santantonio, T., Mazzola, M., Iacovazzi, T., Miglietta, A., Guastadisegni, A. & Pastore, G. (2000) Long-term follow-up of patients with anti-HBe/HBV DNA-positive chronic hepatitis B treated for 12 months with lamivudine. J. Hepatol., 32, 300-306.
20. Stuyver, L., De Gendt, S., Van Geyt, C., Zoulim, F., Fried, M., Schinazi, R.F. & Rossau, R. (2000) A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J. Gen. Virol., 81, 67-74.
21. Stuyver, L.J., Locarnini, S.A., Lok, A., Richman, D.D., Carman, W.F., Dienstag, J.L. & Schinazi, R.F. (2001) Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region. Hepatology, 33, 751-757.
22. Tenney, D.J., Levine, S.M., Rose, R.E., Walsh, A.W., Weinheimer, S.P., Discotto, L., Plym, M., Pokornowski, K., Yu, C.F. Angus, P., Ayres, A., Bartholomeusz, A., Sievert, W., Thompson, G., Warner, N., Locarnini, S. & Colonno, R.J. (2004) Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine. Antimicrob. Agents Chemother, 48, 3498-3507.
23. Wang, J.H., Lu, S.N., Lee, C.M., Lee, J.F. & Chou, Y.P. (2002) Fatal hepatic failure after emergence of the hepatitis B virus mutant during lamivudine therapy in a patient with liver cirrhosis. Scand. J. Gastroenterol., 37, 366-369.
24. Yao, F.Y. & Bass, N.M. (2000) Lamivudine treatment in patients with severely decompensated cirrhosis due to replicating hepatitis B infection. J. Hepatol., 33, 301-307.
25. Yao, F.Y., Terrault, N.A., Freise, C., Maslow, L. & Bass, N.M. (2001) Lamivudine treatment is beneficial in patients with severely decompensated cirrhosis and actively replicating hepatitis B infection awaiting liver transplantation: a comparative study using a matched, untreated cohort. Hepatology, 34, 411-416.
26. Yim, H.J., Hussain, M., Liu, Y., Wong, S.N., Fung, S.K. & Lok, A.S. (2006) Evolution of multi-drug resistant hepatitis B virus during sequential therapy. Hepatology, 44, 703-712.
27. Yuen, M.F., Tanaka, Y. & Lai, C.L. (2003) Hepatitis B genotypes in chronic hepatitis B and lamivudine therapy. Intervirology, 46, 373-376.