Food deprivation induces adipose plasminogen activator inhibitor-1 (PAI-1) expression without accumulation of plasma PAI-1 in genetically obese and diabetic db/db mice

Thrombosis and Haemostasis

Volumn 98, Issue 4, 2007, Pages 864-870

  Oishi, Katsutaka ^a   Ohkura, Naoki ^b   Matsuda, Juzo ^b   Ishida, Norio ^a,c  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Adipose tissue; db db mouse; Food deprivation; Liver; Obesity; Plasminogen activator inhibitor 1

Indexed keywords

CORTICOSTERONE; FATTY ACID; GLUCOCORTICOID; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICOSTERONE BLOOD LEVEL; DIABETES MELLITUS; EPIDIDYMIS; FATTY ACID BLOOD LEVEL; FIBRINOLYSIS; FOOD DEPRIVATION; INTESTINE; LEAN BODY WEIGHT; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UPREGULATION; WILD TYPE;

ADIPOSE TISSUE; ANIMAL FEED; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; EPIDIDYMIS; FOOD DEPRIVATION; GENE EXPRESSION REGULATION; INSULIN RESISTANCE; MALE; MICE; MICE, OBESE; OBESITY; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, LEPTIN;

EID: 35048898688     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH07-04-0268     Document Type: Article

References (41)

1. Van Gaal LF, et al. Mechanisms linking obesity with cardiovascular disease. Nature 2006; 444: 875-880.
2. Anand SS, et al. Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease. Circulation 2003; 108: 420-425.
3. Mertens I, Van Gaal LF. Visceral fat as a determinant of fibrinolysis and hemostasis. Semin Vasc Med 2005; 5: 48-55.
4. Trost S, et al. Impaired fibrinolysis and risk for cardiovascular disease in the metabolic syndrome and type 2 diabetes. Curr Diab Rep 2006; 6: 47-54.
5. Alessi MC, Juhan-Vague I. PAI-1 and the metabolic syndrome: links, causes, and consequences. Arterioscler Thromb Vase Biol 2006; 26: 2200-2207.
6. Mutch NJ, et al. Plasminogen activator inhibitor-1 and haemostasis in obesity. Proc Nutr Soc 2001; 60: 341-347.
7. Vaughan DE, et al. Studies of recombinant plasminogen activator inhibitor-1 in rabbits. Pharmacokinetics and evidence for reactivation of latent plasminogen activator inhibitor-1 in vivo. Circ Res 1990; 67: 1281-1286.
8. Eren M, et al. Tissue- and agonist-specific regulation of human and murine plasminogen activator inhibitor-1 promoters in transgenic mice. J Thromb Haemost 2003; 1: 2389-2396.
9. Skurk T, Hauner H. Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1. Int J Obes Relat Metab Disord 2004; 28: 1357-1364.
10. Vaughan DE. PAI-1 and atherothrombosis. J Thromb Haemost 2005; 3: 1879-1883.
11. Samad F, Loskutoff DJ. The fat mouse: a powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity/NIDDM. Thromb Haemost 1997; 78: 652-655.
12. Shimomura I, et al. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med 1996; 2: 800-801
13. Samad F, Loskutoff DJ. Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice. Mol Med 1996; 2: 568-582.
14. Lijnen HR, et al. On the role of plasminogen activator inhibitor-1 in adipose tissue development and insulin resistance in mice. J Thromb Haemost 2005; 3: 1174-1179.
15. Coleman DL. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978; 14: 141-148.
16. Oishi K, et al. Gene- and tissue-specific alterations of circadian clock gene expression in streptozotocin-induced diabetic mice under restricted feeding. Biochem. Biophys Res Commun 2004; 317: 330-334.
17. Oishi K, et al. CLOCK is involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression. J Thromb Haemost 2006; 4: 1774-1780.
18. Oishi K, et al. Tissue-specific augmentation of circadian PAI-1 expression in mice with streptozotocin-induced diabetes. Thromb Res 2004; 114: 129-135.
19. Ohkura N, et al. Circadian clock molecules CLOCK and CRYs modulate fibrinolytic activity by regulating the PAI-1 gene expression. J Thromb Haemost 2006; 4: 2478-2485.
20. Oishi K, et al. Identification of the circadian clock-regulated E-box element in the mouse plasminogen activator inhibitor-1 gene. J Thromb Haemost 2007; 5: 428-431.
21. Maemura K, et al. CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. J Biol Chem 2000; 275: 36847-36851.
22. Alessi MC, et al. Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation. Arterioseler Thromb Vasc Biol 2003; 23: 1262-1268.
23. van Hinsbergh VW, et al. Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo. Blood 1988; 72: 1467-1473.
24. Hopkins WE, et al. Synergistic induction of plasminogen activator inhibitor type-1 in HEP G2 cells by thrombin and transforming growth factor-beta. Blood 1992; 79: 75-81.
25. Healy AM, Gelehrter TD. Induction of plasminogen activator inhibitor-1 in HepG2 human hepatoma cells by mediators of the acute phase response. J Biol Chem 1994; 269: 19095-100.
26. Yamashita M. Tumor necrosis factor alpha is involved in the induction of plasminogen activator inhibitor-1 by endotoxin. Thromb Res 1997; 87: 165-170.
27. Dong J, et al. IL-1 and IL-6 induce hepatocyte plasminogen activator inhibitor-1 expression through independent signaling pathways converging on C/EBPdelta. Am J Physiol Cell Physiol 2007; 292: C209-215.
28. Alessi MC, et al. Insulin stimulates the synthesis of plasminogen activator inhibitor 1 by the human hepatocellular cell line Hep G2. Thromb Haemost 1988; 60: 491-494.
29. Kooistra T, et al. Plasminogen activator inhibitor 1: biosynthesis and mRNA level are increased by insulin in cultured human hepatocytes. Thromb Haemost 1989; 62: 723-728.
30. Konkle BA, et al. Plasminogen activator inhibitor-1 messenger RNA expression is induced in rat hepatocytes in vivo by dexamethasone. Blood 1992; 79: 2636-2642.
31. Anfosso F, et al. Up-regulated expression of plasminogen activator inhibitor-1 in Hep G2 cells: interrelationship between insulin and insulin-like growth factor 1. Thromb Haemost 1995; 73: 268-274.
32. Sironi L, et al. Plasminogen activator inhibitor type-1 synthesis and mRNA expression in HepG2 cells are regulated by VLDL. Arterioscler Thromb Vasc Biol 1996; 16: 89-96.
33. Banfi C, et al. Very low density lipoprotein-mediated signal transduction and plasminogen activator inhibitor type 1 in cultured HepG2 cells. Circ Res 1999; 85: 208-217.
34. Chen Y, et al. Effect of fatty acid chain length and thioesterification on the augmentation of expression of plasminogen activator inhibitor-1. Nutr Metab Cardiovasc Dis 2002; 12: 325-330.
35. Sawdey MS, Loskutoff DJ. Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta. J Clin Invest 1991; 88: 1346-1353.
36. Kudo T, et al. Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver. Diabetologia 2004; 47: 1425-1436.
37. Alessi MC, et al. Production of plasminogen activator inhibitor 1 by human adipose tissue: possible link between visceral fat accumulation and vascular disease. Diabetes 1997; 46: 860-867.
38. Gottschling-Zeller H, et al. Effect of tumor necrosis factor alpha and transforming growth factor beta 1 on plasminogen activator inhibitor-1 secretion from subcutaneous and omental human fat cells in suspension culture. Metabolism 2000; 49: 666-671.
39. Bastard JP, et al. Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 gene during very low calorie diet in obese subjects. Int J Obes Relat Metab Disord 2000; 24: 70-74.
40. Correia ML, Haynes WG. A role for plasminogen activator inhibitor-1 in obesity: from pie to PAI? Arterioscler Thromb Vase Biol 2006; 26: 2183-2185.
41. Yamamoto K, et al. Obesity enhances the induction of plasminogen activator inhibitor-1 by restraint stress: a possible mechanism of stress-induced renal fibrin deposition in obese mice. J Thromb Haemost 2005; 3: 1495-1502.