A 31-phosphorus neurospectroscopy study of ω-3 long-chain polyunsaturated fatty acid intervention with eicosapentaenoic acid and docosahexaenoic acid in patients with chronic refractory epilepsy

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 77, Issue 2, 2007, Pages 105-107

  Puri, B K ^a   Koepp, M J ^b,c   Holmes, J ^a   Hamilton, G ^d   Yuen, A W C ^b,c  

^a MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

^b NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^c EPILEPSY SOCIETY   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; PHOSPHODIESTERASE; PHOSPHOLIPID; PLACEBO;

ARTICLE; BILAYER MEMBRANE; BRAIN MEMBRANE; BRAIN METABOLISM; BRAIN PROTECTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ENERGY METABOLISM; EPILEPSY; FEMALE; HUMAN; MALE; NEUROIMAGING; NEUROPROTECTION; PHOSPHOLIPID BLOOD LEVEL; PHOSPHOLIPID SYNTHESIS; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; BRAIN; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; EPILEPSY; FATTY ACIDS, OMEGA-3; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MIDDLE AGED; PILOT PROJECTS; PLACEBOS;

EID: 35048842759     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2007.07.004     Document Type: Article

References (15)

1. Haag M. Essential fatty acids and the brain. Can. J. Psychiatry 48 (2003) 195-203
2. Xiao Y., and Li X. Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation. Brain Res. 846 (1999) 112-121
3. Voskuyl R.A., Vreugdenhil M., Kang J.X., and Leaf A. Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur. J. Pharmacol. 341 (1998) 145-152
4. Yuen A.W.C., Sander J.W., Fluegel D., et al. Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial. Epilepsy Behav. 7 (2005) 253-258
5. Bottomley P.A., Hart H.R., Edelstein W.A., et al. Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla. Radiology 150 (1984) 441-446
6. 31P NMR spectroscopic study. Magn. Reson. Med. 6 (1988) 296-299
7. Hamilton G., Mathur R., Allsop J.M., et al. Changes in brain intracellular pH and membrane phospholipids on oxygen therapy in hypoxic patients with chronic obstructive pulmonary disease. Metab. Brain Dis. 18 (2003) 95-109
8. Vanhamme L., Van Den Boogaart A., and Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J. Magn. Reson. 129 (1997) 35-43
9. Naressi A., Couturier C., Devos J.M., et al. Java-based graphical user interface for the MRUI quantitation package. MAGMA 12 (2001) 141-152
10. Richardson A.J., Cox I.J., Sargentoni J., and Puri B.K. Abnormal cerebral phospholipid metabolism in dyslexia indicated by phosphorus-31 magnetic resonance spectroscopy. NMR Biomed. 10 (1997) 309-314
11. Cox I.J., and Puri B.K. In vivo MR spectroscopy in diagnosis and research of neuropsychiatric disorders. Prostaglandins Leukot. Essent. Fatty Acids 70 (2004) 357-360
12. Puri B.K., Counsell S.J., Hamilton G., et al. Cerebral metabolism in male patients with schizophrenia who have seriously and dangerously violently offended. Prostaglandins Leukot. Essent. Fatty Acids 70 (2004) 409-411
13. Puri B.K. Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia. Int. Rev. Psychiatry 18 (2006) 145-147
14. Puri B.K., Richardson A.J., Horrobin D.F., et al. Eicosapentaenoic acid treatment in schizophrenia associated with symptom remission, normalisation of blood fatty acids, reduced neuronal membrane phospholipid turnover and structural brain changes. Int. J. Clin. Pract. 54 (2000) 57-63
15. Puri B.K., Counsell S.J., Hamilton G., Richardson A.J., and Horrobin D.F. Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover. Int. J. Clin. Pract. 55 (2001) 560-563