Efficacy of camptothecin and polymer-conjugated camptothecin in tumor spheroids and solid tumors

Journal of Biomaterials Science, Polymer Edition

Volumn 18, Issue 10, 2007, Pages 1283-1299

  Ying, Victoria ^a,d   Haverstick, Kraig ^b,e   Page, Rodney L ^a   Saltzman, W Mark ^b,c  

^a Animal Health Diagnostic Center   (United States)

^b Cornell University   (United States)

^c Yale University   (United States)

^d NEW YORK CITY COLLEGE OF TECHNOLOGY   (United States)

^e Brown and Michaels PC   (United States)

Author keywords

Camptothecin; Chemotherapy; Collagen gel; Spheroids; Tumors

Indexed keywords

AMINO ACIDS; CHEMOTHERAPY; CONJUGATED POLYMERS; HYDROLYSIS; POLYETHYLENE GLYCOLS; SOLUBILITY; TUMORS;

ANTI CANCER DRUGS; CAMPTOTHECIN; COLLAGEN GELS; SOLID TUMORS; TUMOR SPHEROIDS;

DRUG PRODUCTS;

CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; CARBOXYLMETHYL POLY(ETHYLENE GLYCOL)CAMPTOTHECIN; CARBOXYLMETHYL POLY(ETHYLENE GLYCOL)GLYCINE CAMPTOTHECIN; CARBOXYLMETHYL POLY(ETHYLENE GLYCOL)SARCOSINE CAMPTOTHECIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG EFFECT; DRUG SOLUBILITY; DRUG SYNTHESIS; HYDROLYSIS; HYDROPHILICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SOLID TUMOR; TUMOR SPHEROID;

RATTUS;

EID: 35048837048     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1163/156856207782177918     Document Type: Article

References (12)

1. A. B. Fleming, K. Haverstick and W. M. Saltzman, Bioconjug. Chem. 15, 1364 (2004).
2. C. H. Takimoto and S. G. Arbuck, Cancer Chemotherapy and Biotherapy: The Camptothecins. Lippincott-Raven, Philadelphia, PA (1996).
3. R. B. Greenwald, A. Pendri, C. D. Conover, C. Lee, Y. H. Choe, C. Gilbert, A. Martinez, J. Xia, D. Wu and M. Hsue, Bioorg. Med. Chem. 6, 551 (1998).
4. T. G. Burke and D. Bom, Ann. NY Acad. Sci. 922, 36 (2000).
5. L. K. Fung, M. Shin, B. Tyler, H. Brem and W. M. Saltzman, Pharm. Res. 13, 671 (1996).
6. L. K. Fung, M. G. Ewend, A. Sills, E. P. Sipos, R. Thompson, M. Watts, O. M. Colvin, H. Brem and W. M. Saltzman, Cancer Res. 58, 672 (1998).
7. W. Dang, O. M. Colvin, H. Brem and W. M. Saltzman, Cancer Res. 54, 1729 (1994).
8. R. J. Tamargo, J. S. Myseros, J. I. Epstein, M. B. Yang, M. Chasin and H. Brem, Cancer Res. 53, 329 (1993).
9. R. G. Steen, R. J. Tamargo, K. A. McGovern, S. S. Rajan, H. Brem, J. P. Wehrle and J. D. Glickson, Cancer Res. 48, 676 (1988).
10. S. L. Schor, A. M. Schor, B. Winn and G. Rushton, Int. J. Cancer. 29, 57 (1982).
11. L. A. Kunz-Schughart, Cell Biol. Int. 23, 157 (1999).
12. E. Kaczarek, S. Zapf, H. Bouterfa, J. C. Tonn, M. Westphal and A. Giese, Int. J. Dev. Neurosci. 17, 625 (1999).