The angiotensin-converting enzyme insertion/deletion polymorphism and serum levels of angiotensin-converting enzyme in venous thromboembolism. Data from a case control study

Thrombosis and Haemostasis

Volumn 98, Issue 4, 2007, Pages 777-782

  Ay, Cihan ^a   Bencur, Peter ^a   Vormittag, Rainer ^a   Sailer, Thomas ^a   Jungbauer, Christof ^b   Vukovich, Thomas ^a   Mannhalter, Christine ^a   Pabinger, Ingrid ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Austrian Red Cross   (Austria)

Author keywords

Angiotensin converting enzyme; Deep venous thrombosis; Insertion deletion polymorphism; Pulmonary embolism; Venous thromboembolism

Indexed keywords

ANTICOAGULANT AGENT; DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; CONFIDENCE INTERVAL; CONTROLLED STUDY; ENZYME ASSAY; ENZYME BLOOD LEVEL; FEMALE; FIBRINOLYSIS; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENETIC POLYMORPHISM; GENOTYPE; HIGH RISK PATIENT; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; VENOUS THROMBOEMBOLISM;

ABO BLOOD-GROUP SYSTEM; ADULT; AGED; CASE-CONTROL STUDIES; FEMALE; GENE DELETION; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC; PULMONARY EMBOLISM; VENOUS THROMBOEMBOLISM; VENOUS THROMBOSIS;

EID: 35048835154     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH07-03-0209     Document Type: Article

References (28)

1. Nishimura H, Tsuji H, Masuda H, et al. The effects of angiotensin metabolites on the regulation of coagulation and fibrinolysis in cultured rat aortic endothelial cells. Thromb Haemost 1999; 82: 1516-1521.
2. Vaughan DE. The renin-angiotensin system and fibrinolysis. Am J Cardiol 1997; 79: 12-16.
3. Hayes LW, Goguen CA, Ching SF, et al. Angiotensin-converting enzyme: accumulation in medium from cultured endothelial cells. Biochem Biophys Res Commun 1978; 82: 1147-1153.
4. Beneteau-Burnat B, Baudin B. Angiotensin-converting enzyme: clinical applications and laboratory investigations on serum and other biological fluids. Crit Rev Clin Lab Sci 1991; 28: 337-3356.
5. Rigat B, Hubert C, Corvol P, et al. PCR detection of the insertion/ deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res 1992; 20: 1433.
6. Rigat B, Hubert C, Alhenc-Gelas F, et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-1346.
7. Tiret L, Rigat B, Visvikis S, et al. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 1992; 51: 197-205.
8. Okumus G, Arseven O. Insertion/deletion polymorphism of the angiotensin-converting enzyme gene: really a risk factor for venous thromboembolism? Thromb Haemost 2003; 90: 766-767.
9. Philipp CS, Dilley A, Saidi P, et al. Deletion polymorphism in the angiotensin-converting enzyme gene as a thrombophilic risk factor after hip arthroplasty. Thromb Haemost 1998; 80: 869-873.
10. von Depka M, Czwalinna A, Wermes C, et al. The deletion polymorphism in the angiotensin-converting enzyme gene is a moderate risk factor for venous thromboembolism. Thromb Haemost 2003; 89: 847-852.
11. Lu Y, Hui R, Zhao Y. Insertion/deletion polymorphsim of the angiotensin I converting enzyme gene and pulmonary thromboembolism in Chinese population. Zhonghua Jie He He Hu Xi Za Zhi 2001; 24:265-268.
12. Fatini C, Gensini F, Sticchi E, et al. ACE DD genotype: an independent predisposition factor to venous thromboembolism. Eur J Clin Invest 2003; 33: 642-647.
13. Jackson A, Brown K, Langdown J, et al. Effect of the angiotensin-converting enzyme gene deletion polymorphism on the risk of venous thromboembolism. Br J Haematol 2000; 111: 562-564.
14. Wells PS, Rodger MA, Forgie MA, et al. The ACE D/D genotype is protective against the development of idiopathic deep vein thrombosis and pulmonary embolism. Thromb Haemost 2003; 90: 829-834.
15. Buddingh EP, Van Hylckama Vlieg A, Rosendaal FR. The angiotensin-converting enzyme gene insertion/deletion polymorphism: insufficient evidence for a role in deep venous thrombosis. J Thromb Haemost 2005; 3: 403-404.
16. Koppel H, Renner W, Gugl A, et al. The angiotensin-converting-enzyme insertion/deletion polymorphism is not related to venous thrombosis. Thromb Haemost 2004; 91: 76-79.
17. Gonzalez Ordonez AJ, Fernandez Carreira JM, Medina Rodriguez JM, et al. Risk of venous thromboembolism associated with the insertion/deletion polymorphism in the angiotensin-converting enzyme gene. Blood Coagul Fibrinolysis 2000; 11: 485-490.
18. Pabinger I, Grafenhofer H, Kaider A, et al. Pre-eclampsia and fetal loss in women with a history of venous thromboembolism. Arterioscler Thromb Vasc Biol 2001; 21: 874-879.
19. Vormittag R, Vukovich T, Schonauer V, et al. Basal high-sensitivity-C-reactive protein levels in patients with spontaneous venous thromboembolism. Thromb Haemost 2005; 93: 488-493.
20. Vormittag R, Hsieh K, Kaider A, et al. Interleukin-6 and interleukin-6 promoter polymorphism (-174) G > C in patients with spontaneous venous thromboembolism. Thromb Haemost 2006; 95: 802-806.
21. Dilley A, Austin H, Hooper WC, et al. Relation of three genetic traits to venous thrombosis in an African-American population. Am J Epidemiol 1998; 147: 30-35.
22. Della Valle CJ, Issack PS, Baitner A, et al. The relationship of the factor V Leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty. BMC Musculoskelet Disord 2001; 2: 1.
23. Ekim N, Oguzulgen IK, Demir N, et al. The role of angiotensin-converting enzyme gene polymorphism in pulmonary thromboembolism. Thromb Haemost 2004; 92: 432-433.
24. Dilley A, Austin H, El-Jamil M, et al. Genetic factors associated with thrombosis in pregnancy in a United States population. Am J Obstet Gynecol 2000; 183: 1271-1277.
25. Munoz Mendez 3, Alfajeme Michavila I, Hernandez Borge J, et al. Angiotensin-converting enzyme in pulmonary thromboembolism as a marker of vascular lesion. Rev Clin Esp 1997; 197: 84-91.
26. Drouet L, Baudin B, Baumann FC, et al. Serum angiotensin-converting enzyme: an endothelial cell marker. Application to thromboembolic pathology. J Lab Clin Med 1988; 112: 450-457.
27. Cidl K, Strelcova L, Znojil V, et al. Angiotensin I-converting enzyme (ACE) polymorphism and ABO blood groups as factors codetermining plasma ACE activity. Exp Hematol 1996; 24: 790-794.
28. King MJ. Blood group antigens on human erythrocytes-distribution, structure and possible functions. Biochim Biophys Acta 1994; 1197: 15-44.