Acute hearing loss in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)

Acta Neurologica Taiwanica

Volumn 16, Issue 3, 2007, Pages 168-172

  Chen, Jui Cheng ^a   Tsai, Tzung Chang ^a   Liu, Chin San ^b   Lu, Chung Ta ^a  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

Author keywords

Acute deafness; DM; Epilepsy; MELAS; Mitochondrial disease; RRF

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CARNITINE; DEXAMETHASONE; LACTIC ACID; PYRUVIC ACID; UBIDECARENONE;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; ELECTROENCEPHALOGRAPHY; EPILEPTIC DISCHARGE; GENETIC ANALYSIS; HEARING LOSS; HUMAN; HUMAN TISSUE; MALE; MELAS SYNDROME; MITOCHONDRIAL GENE; MUSCLE BIOPSY; NUCLEAR MAGNETIC RESONANCE IMAGING; PERCEPTION DEAFNESS; POINT MUTATION; VIRUS ENCEPHALITIS;

ACUTE DISEASE; ADULT; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HEARING LOSS; HUMANS; MALE; MELAS SYNDROME;

EID: 35048818019     PISSN: 10196099     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Goto Y, Horai S, Matsuoka T, et al. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): a correlative study of the clinical features and mitochondrial DNA mutation. Neurology 1992;42:545-50.
2. Ohama E, Ohara S, Ikuta F, et al. Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy. Acta Neuropathol (Berl) 1987;74:226-33.
3. Abe K, Yoshimura H, Tanaka H, et al. Comparison of conventional and diffusion-weighted MRI and proton MR spectroscopy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like events. Neuroradiology 2004;46:113-7.
4. Ciafaloni E, Ricci E, Shanske S, et al. MELAS: clinical features, biochemistry, and molecular genetics. Ann Neurol 1992;31:391-8.
5. Tanahashi C, Nakayama A, Yoshida M, et al. MELAS with the mitochondrial DNA 3243 point mutation: a neuropathological study. Acta Neuropathol (Berl) 2000;99:31-8.
6. Liu CS, Cheng WL, Lee CF, et al. Alteration in the copy number of mitochondrial DNA in leukocytes of patients with mitochondrial encephalomyopathies. Acta Neurol Scand 2006;113:334-41.
7. Warrick PD, Wardrop P, Sim DW. Sensorineural hearing loss in MELAS syndrome. J Laryngol Otol 1997;111:279-81.
8. Tamagawa Y, Kitamura K, Hagiwara H, et al. Audiologic findings in patients with a point mutation at nucleotide 3,243 of mitochondrial DNA. Ann Otol Rhinol Laryngol 1997;106:338-42.
9. Wallace DC. Mitochondrial diseases in man and mouse. Science 1999;283:1482-8.
10. Rosenthal EL, Kileny PR, Boerst A, et al. Successful cochlear implantation in a patient with MELAS syndrome. Am J Otol 1999;20:187-90.
11. Scaglia F, Northrop JL. The mitochondrial myopathy, encephalopathy, lactic acidosis with stroke-like episodes (MELAS) syndrome: a review of treatment options. CNS Drugs 2006;20:443-64.
12. Matthews PM, Ford B, Dandurand RJ, et al. Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease. Neurology 1993;43:884-90.
13. Huang CC, Kuo HC, Chu CC, et al. Clinical phenotype, prognosis and mitochondrial DNA mutation load in mitochondrial encephalomyopathies. J Biomed Sci 2002;9:527-33.