Lepidepyrone, a new γ-pyrone derivative, from Neolentinus lepideus, inhibits hyaluronidase

Journal of Antibiotics

Volumn 60, Issue 6, 2007, Pages 388-390

  Hosoe, Tomoo ^a   Sakai, Hideo ^a   Ichikawa, Makoto ^a   Itabashi, Takeshi ^a   Ishizaki, Takayuki ^b   Kawai, Ken Ichi ^a  

^a HOSHI UNIVERSITY   (Japan)

^b TAMAGAWA UNIVERSITY   (Japan)

Author keywords

pyrone derivative; Hyaluronidase inhibitor; Lepidepyrone; Neolentinus lepideus

Indexed keywords

4 PYRONE DERIVATIVE; ENZYME INHIBITOR; HYALURONIDASE; HYALURONIDASE ANTIBODY; LEPIDEPYRONE; UNCLASSIFIED DRUG; HYALURONOGLUCOSAMINIDASE; PYRONE DERIVATIVE;

ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; FUNGUS CULTURE; MUSHROOM; MYCELIUM; NEOLENTINUS LEPIDEUS; NONHUMAN; PRIORITY JOURNAL; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; BASIDIOMYCETES; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; IC 50; INFRARED SPECTROPHOTOMETRY; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROPHOTOMETRY;

BASIDIOMYCOTA; NEOLENTINUS LEPIDEUS;

BASIDIOMYCOTA; ENZYME INHIBITORS; HYALURONOGLUCOSAMINIDASE; INHIBITORY CONCENTRATION 50; MASS SPECTROMETRY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PYRONES; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 34948911252     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2007.53     Document Type: Article

References (7)

1. Laurent TC, Fraser JRE. Hyaluronan. FASEB J 6: 2397-2405 (1992)
2. Alexander B, Daniel JR, Stephan B, Masatoshi N, Sumnhild S, Julia H, Günther B, Stefan D, Mark JJ, Armin B. L-Ascorbic acid 6-hexadecanoate, a potent hyaluronidase inhibitor. J Biol Chem 44: 45990-45997 (2004)
3. Wat C-K, Neil Towers GH. Production of methylated phenolic acids by species of Lentinus (Bashidiomysete). Phytochem 16: 290-291 (1977)
4. Chu M, Mierzwa R, Xu L, He L, Terracciano J, Patel M, Zhao W, Black TA, Chan T-M. Structure of Sch 419560, a novel α-pyrone antibiotic produced by Pseudomonas fluorescens. J Antibiot 55: 215-218 (2002)
5. Kobayashi M, Matsushita H, Yoshida K, Tsukiyama R, Sugiyama T, Yamamoto K. In vitro and in vivo anti-allergenic activity of soy sauce. Inter J Molec Medicine 14: 879-884 (2004)
6. Fujitani N, Sakaki S, Yamaguchi Y, Takenaka H. Inhibitory effects of microalgae on the activation of hyaluronidase. J Appl Physiol 13: 489-492 (2000)
7. Spickenreiter M, Braun S, Bernhardt G, Dove S, Buschauer A. Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases. Bioorg Med Chem Lett 16: 5313-5316 (2006)